НЕЙРОЭНДОКРИННЫЕ ОПУХОЛИ ПИЩЕВАРИТЕЛЬНОЙ СИСТЕМЫ: МОРФОЛОГИЧЕСКИЙ СПЕКТР И КЛЕТОЧНАЯ ПРОЛИФЕРАЦИЯ (ИНДЕКС KI67)

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Обзор посвящен анализу современных представлений о различных типах нейроэндокринных новообразований пищеварительной системы человека. В нем обобщены сведения об особенностях последних гистологических классификаций и критериях морфологической диагностики с учетом гистологических, ультраструктурных, и иммуногистохимических параметров. Обсуждаются вопросы номенклатуры, а также системы градации и стадирования. В свете этих критериев также представлены данные собственных исследований по клинической значимости определения пролиферативной активности клеток первичных и метастатических нейроэндокринных новообразований желудочно-кишечного тракта и поджелудочной железы на основе оценки экспрессии антигена Ki67.

 

Об авторах

В. В. Делекторская

Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва, Российская Федерация

Автор, ответственный за переписку.
Email: delektorskaya@yandex.ru
PhD, Head of the Histochemistry and Electron Microscopy Laboratory, N. N. Blokhin Russian Cancer Research Center of RAMS Address: 115478, Moscow, Kashirskoye Highway 24; tel.: (499) 324-61-11 Россия

Н. Е. Кушлинский

Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва, Российская Федерация

Email: biochimia@mtu-net.ru
PhD, Professor, RAMS cor. member, Head of the Clinical Biochemistry Laboratory, N. N. Blokhin Russian Cancer Research Center of RAMS Address: 115478, Moscow, Kashirskoye Highway 24; tel.: (499) 324-11-59 Россия

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