KIM-1 и другие маркеры острого повреждения почек при цисплатин-индуцированной нефротоксичности

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Аннотация

Нефротоксичность — один из главных дозолимитирующх факторов применения цисплатина в противоопухолевой химиотерапии. Ограничения традиционных показателей функционального состояния почек — креатинина и азота мочевины в крови — делают актуальным поиск новых информативных маркеров, которые позволяют на раннем этапе диагностировать цисплатин-индуцированную нефротоксичность с целью адекватного поддержания почечной функции и своевременной коррекции плана лечения. В настоящем обзоре дана общая характеристика биомаркеров острого повреждения почек (ОПП), к которым в этом аспекте сегодня привлечено особое внимание. Представлены экспериментальные и клинические данные последних лет, касающиеся указанных показателей при развитии цисплатин-индуцированного ОПП, с акцентом на одном из наиболее перспективных маркеров — молекуле повреждения почек 1 (kidney injury molecule 1, KIM-1).

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Наталья Сергеевна Сергеева

Московский научно-исследовательский онкологический институт им. П.А. Герцена

Email: prognoz.01@mail.ru
ORCID iD: 0000-0001-7406-9973
SPIN-код: 1805-8141

д.б.н., профессор

Россия, Москва

Татьяна Анатольевна Кармакова

Московский научно-исследовательский онкологический институт им. П.А. Герцена

Автор, ответственный за переписку.
Email: kalmar123@yandex.ru
ORCID iD: 0000-0002-8017-5657
SPIN-код: 4364-6134

д.б.н.

Россия, Москва

Виктория Владимировна Савчина

Московский научно-исследовательский онкологический институт им. П.А. Герцена

Email: Savchina_v.v@mail.ru
ORCID iD: 0000-0002-8721-8437
SPIN-код: 1263-7777

врач-химиотерапевт

Россия, Москва

Игорь Игоревич Алентов

Московский научно-исследовательский онкологический институт им. П.А. Герцена

Email: igoralentov@yandex.ru
ORCID iD: 0000-0002-5920-5823
SPIN-код: 9992-7676

к.б.н., старший научный сотрудник

Россия, Москва

Елена Юрьевна Карпенко

Московский научно-исследовательский онкологический институт им. П.А. Герцена

Email: karpenko.elena@inbox.ru
ORCID iD: 0000-0003-3529-5964
SPIN-код: 3196-4925

врач-химиотерапевт

Россия, Москва

Нина Викторовна Маршутина

Московский научно-исследовательский онкологический институт им. П.А. Герцена

Email: nin.mars@mail.ru
ORCID iD: 0000-0003-2997-4936
SPIN-код: 8366-9485

к.б.н., научный сотрудник

Россия, Москва

Андрей Дмитриевич Каприн

Национальный медицинский исследовательский центр радиологии; Российский университет дружбы народов

Email: kaprin@mail.ru
ORCID iD: 0000-0001-8784-8415
SPIN-код: 1759-8101

д.м.н., профессор, академик РАМН

Россия, Москва; Москва

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