ГЕНЫ ФЕРМЕНТОВ АНТИОКСИДАНТНОЙ СИСТЕМЫ

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Окислительный стресс играет важную роль в патогенезе значительного числа заболеваний. Важными компонентами защиты клеток от окислительного стресса являются антиоксидантные ферменты, активность которых генетически детерминирована. Распределение частот аллелей и генотипов полиморфизмов генов антиоксидантных ферментов характеризуется межэтнической дифференциацией. Противоречивы  результаты исследований взаимосвязи полиморфизмов генов антиоксидантных ферментов с патологическими состояниями у представителей разных рас и этнических групп.

 

Об авторах

Л. И. Колесникова

Научный центр проблем здоровья семьи и репродукции человека» СО РАМН, Иркутск, Российская Федерация

Автор, ответственный за переписку.
Email: iphr@sbamsr.irk.ru
PhD, professor, corresponding member of RAMS, Director of Scientific Center of Family Health Aspects and Human Reproduction of Siberian Department of RAMS. Address: 16, Timiryazev Street, Irkutsk, RF, 664003; tel.: +7 (3952) 20-76-36 Россия

Т. А. Баирова

Научный центр проблем здоровья семьи и репродукции человека» СО РАМН, Иркутск, Российская Федерация

Email: iphr@sbamsr.irk.ru
PhD, Head of the Laboratory of Clinical Genetics of Scientific Center of Family Health Aspects and Human Reproduction of Siberian Department of RAMS. Address: 16, Timiryazev Street, Irkutsk, RF, 664003; tel.: +7 (3952) 20-73-67 Россия

О. А. Первушина

Научный центр проблем здоровья семьи и репродукции человека» СО РАМН, Иркутск, Российская Федерация

Email: oksana111088@mail.ru
postgraduate of the Laboratory of Socially Significant Infections in Human Reproduction of Scientific Center of Family Health Aspects and Human Reproduction of Siberian Department of RAMS. Address: 16, Timiryazev Street, Irkutsk, RF, 664003; tel./fax: +7 (3952) 20-76-36, 20-73-67 Россия

Список литературы

  1. Kolesnikova L.I., Kurashova N.A., Grebenkina L.A. Vestnik voenno-meditsinskoi akademii = Bulletin of Academy of Military Medicine. 2012; 3: 134–137.
  2. Kolesnikova L.I., Kurashova N.A., Grebenkina L.A., Dolgikh M.I., Labygina A.V., Suturina L.V., Dashiev B.G., Darzhaev Z.Yu. Zdorov'e. Meditsinskaya ekologiya. Nauka = Health. Medical ecology. Science. 2011. 44(1): 38–41.
  3. Kovalenko T.D., Sarkisyan O.G. Rol' antioksidantnoi fermentativnoi sistemy v patogeneze miomy matki. Materialy mezhregional'noi nauchno-prakticheskoi konferentsii «Molodezh' i nauka: itogi i perspektivy» [A Role of Antioxidant Enzyme System in Pathogenesis of Hysteromyoma. Proceedings of the Interregional Scientific Practical Conference “Youth and Science: Results and Perspectives”]. 2006. 81 p.
  4. Semenyuk A.V., Kolesnikova L.I., Kulikov A.A. Klinicheskaya laboratornaya diagnostika = Clinical laboratory diagnostics. 1982; 10: 607–609.
  5. Kolesnikova L.I., Petrova V.A., Kornakova N.V., Labygina A.V., Suturina L.V. Zhurnal akusherstva i zhenskikh boleznei = Journal of obstetrics and women’s diseases. 2008; LVII(1): 52–56.
  6. Levonen A., Vahakangas E., Koponen J. Antioxidant gene therapy for cardiovascular diease: current status and future perspectives. Circulation. 2008; 117 (16): 2142-2150.
  7. Islamov R.R., Rizvanov A.A., Kiyasov A.P. Nevrologicheskii vestnik = Neurological bulletin. 2008; XL(4): 91–100.
  8. Green S.L., Tolwani R.J., Varma S., Quignon P., Galibert F., Cork L.C. Structure, chromosomal location, and analysis of the canine Cu/Zn superoxide dismutase (SOD1) gene. J Hered. 2002; 93 (2): 119-124.
  9. Skvortsova V.I., Limborskaya S.A., Slominskii P.A., Levitskaya N.I., Levitskii G.N., Shadrina M.I., Kondrat'eva E.A. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova = S.S. Korsakov Journal of neurology and psychiatry. 2000; 1: 44–47.
  10. Skvortsova V.I., Limborska S.A., Slominsky P.A., Levitskaya N.I., Levitsky G.N., Shadrina M.I., Kondratyeva E.A. Sporadic amyotrophic lateral sclerosis associated with the D90A CuZn-superoxide dismutase mutations in Russia. European Journal of Neurology. 2001; 8: 167 - 172.
  11. Cebrian A., Pharoah P.D., Ahmed S., Smith P.L., Luccarini C., Luben R., Redman K., Munday H., Easton D.F., Dunning A.M., Ponder B.A. Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer. Cancer Res et al. 2006; 66: 1225–1233.
  12. Oestergaard M.Z., Tyrer J., Cebrian A., Shah M., Dunning A.M., Ponder B.A., Easton D.F., Pharoah P.D. Interactions between genes involved in the antioxidant defence system and breast cancer risk. Br. J. Cancer. 2006; 95: 525–531.
  13. Kang D., Lee K.M., Park S.K., Berndt S.I., Peters U., Reding D., Chatterjee N., Welch R., Chanock S., Huang W.Y., Hayes R.B. Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study. Cancer Epidemiol. Biomarkers Prev. 2007;16: 1581–1586.
  14. Udler M., Maia A.T., Cebrian A., Brown C., Greenberg D., Shah M., Caldas C., Dunning A., Easton D., Ponder B., Pharoah P. Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer. J. Clin. Oncol. 2007; 25: 3015–3023.
  15. Yi J.F., Li Y.M., Liu T., He W.T., Li X., Zhou W.C., Kang S.L., Zeng X.T., Zhang J.Q. Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer. World J. Gastroenterol. 2010; 7: 4738-4746.
  16. Han L., Lee S.W., Yoon J.H., Park Y.G., Choi Y.J., Nam S.W., Lee J.Y., Wang Y.P., Park W.S. Association of SOD1 and SOD2 single nucleotide polymorphisms with susceptibility to gastric cancer in a Korean population. APMIS. 2012; 10: 463-466.
  17. Ergen H.A., Narter F., Timirci O., Isbir T. Effects of manganase superoxide dismutase Ala-9Val polymorphism on prostate cancer: a case-control study. Anticancer Res. 2007; 27 (2): 1227—1230.
  18. Sobkowiak A., Lianeri M., Wudarski M., Lacki J.K., Jagodziński P.P. Manganese superoxide dismutase Ala-9Val mitochondrial targeting sequence polymorphism in systemic lupus erythematosus in Poland. Clin. Rheumatol. 2008; 27: 827—831.
  19. Olson S.H., Carlson M.D., Ostrer H., Harlap S., Stone A., Winters M., Ambrosone C.B. Genetic variants in SOD2, MPO, and NQO1, and risk of ovarian cancer. Gynecol Oncol. 2004; 93: 615–620.
  20. Liu G., Zhou W., Wang L.I., Park S., Miller D.P., Xu L.L., Wain J.C., Lynch T.J., Su L., Christiani D.C. MPO and SOD2 polymorphisms, gender, and the risk of non-small cell lung carcinoma. Cancer Lett. 2004; 214: 69–79.
  21. Semenova N.A., Ryazantseva N.V., Novitskii V.V., Dmitrieva A.I., Chechina O.E., Bychkov V.A., Moiseenko I.P. Byulleten' sibirskoi meditsiny = Bulletin of Siberian medicine. 2009; 3: 64–69.
  22. Maikopova E.V., Alimova F.K., Podol'skaya A.A., Kravtsova O.A. Dnepropetrovsk = Dnepropetrovsk. 2011; 4: 6–9.
  23. Nozik-Grayck E., Suliman H.B., Piantadosi C.A. Extracellular superoxide dismutase. Int. J. Biochem. Cell Biol. 2005; 37: 2466-2471.
  24. Juul K., Tybjaerg-Hansen A., Marklund S., Heegaard N.H., Steffensen R., Sillesen H., Jensen G., Nordestgaard B.G.. Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study. Circulation. 2004; 109: 59–65.
  25. Strokov I.A., Bursa T.R., Zotova E.V., Ametov A.S. Genetika i patogenez oslozhnenii = Genetics and pathogenesis of effects. 2003; 2: 3–5.
  26. Nadif R., Mintz M., Jedlicka A., Bertrand J.P., Kleeberger S.R., Kauffmann F. Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. Free Radic Res. 2005; 39: 1345-1350.
  27. Zhou X.F., Cui J., DeStefano A.L., Chazaro I., Farrer L.A., Manolis A.J., Gavras H., Baldwin C.T. Polymorphisms in the promoter region of catalase gene and essential hypertension. Dis Markers. 2005; 21: 3-7.
  28. Ahn J., Nowell S., McCann S.E., Yu J., Carter L., Lang N.P., Kadlubar F.F., Ratnasinghe L.D., Ambrosone C.B. Associations between catalase phenotype and genotype: modification by epidemiologic factors. Cancer Epidemiol. Biomarkers Prev. 2006; 15 (6): 1217-1222.
  29. Vyalykh E.K., Solodilova M.A., Bushueva O.Yu. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova = S.S. Korsakov Journal of neurology and psychiatry. 2012; 8: 3–7.
  30. Ravn-Haren G., Olsen A., Tjønneland A., Dragsted L.O., Nexø B.A., Wallin H., Overvad K., Raaschou-Nielsen O., Vogel U. Associations between GPX1 Pro198Leu polymorphism, erythrocyte GPX activity, alcohol consumption and breast cancer risk in a prospective cohort study. Carcinogenesis. 2006; 27: 820–825.
  31. Hamanishi T., Furuta H., Kato H., Doi A., Tamai M., Shimomura H., Sakagashira S., Nishi M., Sasaki H., Sanke T., Nanjo K. Functional variants in the glutatione peroxidase-1 gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in Japanese type 2 diabetic patients. Diabetes. 2004; 63: 2455-2460.
  32. Nemoto M., Nishimura R., Sasaki T., Hiki Y., Miyashita Y., Nishioka M., Fujimoto K., Sakuma T., Ohashi T., Fukuda K., Eto Y., Tajima N. Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography. Cardiovascular Diabetology. 2007; 6 (23): 15-21.
  33. Arsova-Sarafinovska Z., Matevska N., Eken A., Petrovski D., Banev S., Dzikova S., Georgiev V., Sikole A., Erdem O., Sayal A., Aydin A., Dimovski A.J. Glutathione peroxidase 1 (GPX1) genetic polymorphism, erythrocyte GPX activity, and prostate cancer risk. Int. Urol. Nephrol. 2009; 41 (1): 63-70.
  34. Ivanov V.P., Polonikov A.V., Solodilova M.A., Panfilov V.I. Kurskii nauchno-prakticheskii vestnik «Chelovek i ego zdorov'e» - Kursk scientific-practical bulletin Human and Heath. 2006; 4: 39–45.
  35. Mackness B., Durrington P.N., Mackness M.I. The paraoxonase gene family and coronary heart disease. Curr. Opin. Lipidol. 2002; 13: 357–362.
  36. Roest M., van Himbergen T.M., Barendrecht A.B., Peeters P.H., van der Schouw Y.T., Voorbij H.A. Genetic and environmental determinants of the PON–1 phenotype. Eur. J. Clin. Invest. 2007; 37 (3): 187–196.
  37. Oliveira S.A., Mansur A.P., Ribeiro C.C., Ramires J.A., Annichino-Bizzacchi J.M. PON1 M/L55 mutation protects high-risk patients against coronary artery disease. Int. J. Cardiol. 2004; 94: 73–77.
  38. Rea I.M., McKeown P.P., McMaster D., Young I.S., Patterson C., Savage M.J., Belton C., Marchegiani F., Olivieri F., Bonafe M., Franceschi C. Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis. Exp Gerontol. 2004; 39 (4): 629–635.
  39. Martinelli N., Girelli D., Olivieri O., Cavallari U., Biscuola M., Trabetti E., Friso S., Pizzolo F., Tenuti I., Bozzini C., Villa G., Ceradini B., Sandri M., Cheng S., Grow M.A., Pignatti P.F., Corrocher R. Interaction between metabolic syndrome and PON1 polymorphisms as a determinant of the risk of coronary artery disease. Clin. Exp. Med. 2005; 5: 20-30.
  40. Gardemann A., Philipp M., Hess K., Katz N., Tillmanns H., Haberbosch W.. The paraoxonase Leu-Met54 and Gln-Arg191 gene polymorphisms are not associated with the risk of coronary heart disease. Atherosclerosis. 2000; 152: 421–431.
  41. Sen-Banerjee S., Siles S., Campos H. Tobacco smoking modifies association between Gln-Arg192 polymorphism of human paraoxonase gene and risk of myocardial infarction. Arterioscler. Thromb. Vasc. Biol. 2000; 20: 2120–2126.
  42. Pati N., Pati U. Paraoxonase gene polymorphism and coronary artery disease in Indian subjects. Inter. J. Cardiol. 1998; 66: 165–168.
  43. Pauk V.V., Tuktarova I.A., Nasibullin T.R., Zueva L.P., Adel'guzhina A.Kh., Khusnutdinova E.K., Mustafina O.E. Molekulyarnaya biologiya = Molecular biology. 2007; 41(4): 601–607.
  44. Grdiс M., Barisic K., Rumora L., Salamunic I., Tadijanovic M., Grubisic T.Z., Psikalova R., Fregar-Mestric Z., Juretic D.. Genetic frequencies of Paraoxonase 1 gene polymorphisms in croatian population. Croatica chemical acta. 2008; 81 (1): 105-111.
  45. I.Pejin-Grubiša, I. Buzadžić, B. Janković-Oreščanin.. Distribution of paraoxonase 1 coding region polymorphisms in Serbian population. Genetika. 2010; 42 (2): 235-247.
  46. Eny K.M., El-Sohemy A., Cornelis M.C., Sung Y.K., Bae S.C. Catalase and PPARgamma2 genotype and risk of systemic lupus erythematosus in Koreans. Lupus. 2005; 12 (5): 351-355.
  47. Suzen H.S., Gucyener E., Sakalli O., Uckun Z., Kose G., Ustel D., Duydu Y. CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population. / H Sinan Suzen, Emel Gucyener, Ozgul Sakalli. Mol Biol Rep. 2010; 37 (1): 87-92.
  48. Srinivasan S.R., Li S., Chen W., Tang R., Bond M.G., Boerwinkle E. Q192R polymorphism of the paraoxanase 1 gene and its association with serum lipoprotein variables and carotid artery intima-media thickness in young adults from a biracial community. The Bogalusa Heart Study. Atherosclerosis. 2004; 177 (1): 167–174.

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