MOLECULAR MECHANISMS OF FORMATION OF CHRONIC PELVIC PAIN SYNDROME IN PATIENTS WITH EXTERNAL GENITAL ENDOMETRIOSIS: MARKERS AND TARGETS FOR DIAGNOSIS AND THERAPY (REVIEW)

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Abstract

This article systematizes the results of studies on the pathogenetic mechanisms of CPPS formation in patients with EGE. Pain is one of the severe clinical manifestations and complications of endometriosis. To ease the pain in patients with EGE is complex but urgent task. Long diagnostic search (mean period 5−8 years) leads to the formation of a persistent Autonomous pain syndrome associated with relapses of pain even after a com-prehensive treatment of patients (surgical and/or long-term hormonal). Patients with endometriosis suffer from mixed pain including neuropathic and nociceptive components which is proved by the example of expression in ectopic foci of specific biomarkers. Therefore, the question of early non-invasive diagnosis of endometriosis is very vital and can be solved by the development of a diagnostic panel consisting of biomarkers expressed by ectopic foci at the initial stage of the disease.

About the authors

Daria E. Nikiforova

Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky

Author for correspondence.
Email: dashsemch@mail.ru
ORCID iD: 0000-0001-7516-5203

MD.

1, Partizana Zheleznyaka street, 660022 Krasnoyarsk, Phone: +7 (495) 627-24-00.

SPIN-код: 1219-6470

Россия

Tatyana A. Makarenko

Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky

Email: makarenko7777@yandex.ru
ORCID iD: 0000-0001-7823-6222

MD, PhD.

1, Partizana Zheleznyaka street, 660022 Krasnoyarsk, Phone: +7 (495) 627-24-00.

SPIN-код: 3133-7406

Россия

Alla B. Salmina

Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky

Email: allasalmina@mail.ru

MD, PhD, Professor.

1, Partizana Zheleznyaka street, 660022 Krasnoyarsk, Phone: +7 (495) 627-24-00.

SPIN-код: 6504-7657

Россия

References

  1. Эндометриоз: диагностика, лечение и реабилитация. Клинические рекомендации по ведению больных / Под ред. Л.В. Адамян. ― М.; 2013. ― 86 с.
  2. May KE, Conduit-Hulbert SA, Villar J, et al. Peripheral biomarkers of endometriosis: a systematic review. Hum Reprod Update. 2010;16(6):651−674. doi: 10.1093/humupd/dmq009.
  3. May KE, Villar J, Kirtley S, et al. Endometrial alterations in endometriosis: a systematic review of putative biomarkers. Hum Reprod Update. 2011;17(5):637−653. doi: 10.1093/humupd/dmr013.
  4. Vodolazkaia A, El-Aalamat Y, Popovic D, et al. Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis. Hum Reprod. 2012;27(9):2698−2711. doi: 10.1093/humrep/des234.
  5. Fassbender A, Burney RO, O DF, et al. Update on biomarkers for the detection of endometriosis. Biomed Res Int. 2015;2015:130854. doi: 10.1155/2015/130854.
  6. Locci R, Nisolle M, Angioni S, et al. Expression of the gamma 2 chain of laminin-332 in eutopic and ectopic endometrium of patients with endometriosis. Reprod Biol Endocrinol. 2013;11:94. doi: 10.1186/1477-7827-11-94.
  7. Gupta D, Hull ML, Fraser I, et al. Endometrial biomarkers for the non-invasive diagnosis of endometriosis. Cochrane Database Syst Rev. 2016;4:CD012165. doi: 10.1002/14651858.CD012165.
  8. Young VJ, Ahmad SF, Brown JK, et al. Peritoneal VEGF-A expression is regulated by TGF-β1 through an ID1 pathway in women with endometriosis. Sci Rep. 2015;5:16859. doi: 10.1038/srep16859.
  9. Wessels JM. Uterine brain-derived neurotrophic factor and endometriosis. [dissertation] Hamilton, Ontario: McMaster University; 2015.
  10. Li X, Zhang Y, Zhao L, et al. Whole-exome sequencing of endometriosis identifies frequent alterations in genes involved in cell adhesion and chromatin-remodeling complexes. Hum Mol Genet. 2014;23(22):6008−6021. doi: 10.1093/hmg/ddu330.
  11. Pino M, Galleguillos C, Torres M, et al. Association between MMP1 and MMP9 activities and ICAM1 cleavage induced by tumor necrosis factor in stromal cell cultures from eutopic endometria of women with endometriosis. Reproduction. 2009;138(5):837−847. doi: 10.1530/rep-09-0196.
  12. Delbandi AA, Mahmoudi M, Shervin A, et al. Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior. Fertil Steril. 2013;100(3):761−769. doi: 10.1016/j.fertnstert.2013.04.041.
  13. Protopapas A, Markaki S, Mitsis T, et al. Immunohistochemical expression of matrix metalloproteinases, their tissue inhibitors, and cathepsin-D in ovarian endometriosis: correlation with severity of disease. Fertil Steril. 2010;94(6):2470−2472. doi: 10.1016/j.fertnstert.2010.03.007.
  14. Young VJ, Brown JK, Maybin J, et al. Transforming growth factor-β induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis. J Clin Endocrinol Metab. 2014;99(9):3450–3459. doi: 10.1210/jc.2014-1026.
  15. Yang YM, Yang WX. Epithelial-to-mesenchymal transition in the development of endometriosis. Oncotarget. 2017;8(25):41679−41689. doi: 10.18632/oncotarget.16472.
  16. Nie J, Liu X, Guo SW. Immunoreactivity of oxytocin receptor and transient receptor potential vanilloid type 1 and its correlation with dysmenorrea in adenomyosis. Am J Obstet Gynecol. 2010;202(4):327–346. doi: 10.1016/j.ajog.2009.11.035.
  17. Чернуха Г.Е. Эндометриоз и хроническая тазовая боль: причины и последствия // Проблемы репродукции. ― 2011. ― №5 ― С. 83−89.
  18. Ростовцева О.О., Волков В.Г., Паклина О.В., Сетдикова Г.Р. Морфологическая, иммуногистохимическая и ультраструктурная характеристика синдрома хронической тазовой боли при наружном генитальном эндометриозе // Вестник новых медицинских технологий. ― 2010. ― Т.17. ― №4 ― С. 142−144.
  19. Данилов А.Б., Давыдов О.С. Нейропатическая боль. ― М.: Боргес; 2007. ― 190 с.
  20. Коган Е.А., Парамонова Н.Б., Демура Т.А., и др. Морфологический субстрат и патогенетические механизмы синдрома тазовой боли при эндометриозе // Архив патологии. ― 2014. ― Т.76. ― №6 ― С. 37−43.
  21. Stratton P, Berkley KJ. Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications. Hum Reprod Update. 2011;17(3):327–346. doi: 10.1093/humupd/dmq050.
  22. gynendo. ru [интернет]. Глобальный консенсус по современному ведению эндометриоза, 2013. https://gynendo.ru/biblioteka/publikatsii/politicheskie-dokumenty/globalnyj-konsensus-po-sovremennom/. Ссылка активна на 15.07.2018.
  23. Коган Е.А., Овакимян А.С., Парамонова Н.Б., и др. Морфологический субстрат и патогенетические механизмы синдрома тазовой боли при эндометриозе. Часть II. Ремоделирование периферической нервной ткани в очагах эндометриоза // Архив патологии. ― 2016. ― Т.78. ― №3 ― С. 20–25.
  24. Wang G, Tokushige N, Russell P, et al. Hyperinnervation in intestinal deep infiltrating endometriosis. J Minim Invasive Gynecol. 2009;16(6):713−719. doi: 10.1016/j.jmig.2009.07.012.
  25. Novella-Maestre E, Herraiz S, Vila-Vives JM, et al. Effect of antiangiogenic treatment on peritoneal endometriosis-associated nerve fibers. Fertil Steril. 2012;98(5):1209−1217. doi: 10.1016/j.fertnstert.2012.07.1103.
  26. Wang G, Tokushige N, Markham R, Fraser IS. Rich innervation of deep infiltrating endometriosis. Hum Reprod. 2009;24(4):827–34. doi: 10.1093/humrep/den464.
  27. Rocha AL, Vieira EL, Ferreira MC, et al. Plasma brain-derived neurotrophic factor in women with pelvic pain: a potential biomarker for endometriosis? Biomark Med. 2017;11(4):313−317. doi: 10.2217/bmm-2016-0327.
  28. Семерикова М.В., Качалина Т.С., Стронгин Л.Г. Иммунный статус у больных с наружным генитальным эндометриозом, ассоциированным с гипотиреозом // Российский вестник акушера-гинеколога. ― 2011. ― Т.11. ― №3 ― С. 14−16.
  29. Ярмолинская М.И., Беженарь В.Ф. Опыт применения диеногеста в комбинированном лечении генитального эндометриоза // Фарматека. ― 2013. ― №3. ― С. 48−51.
  30. Tosti C, Biscione A, Morgante G, et al. Hormonal therapy for endometriosis: from molecular research to bedside. Eur J Obstet Gynecol Reprod Biol. 2017;209:61−66. doi: 10.1016/j.ejogrb.2016.05.032.
  31. Ярмолинская М.И., Айламазян Э.К. Генитальный эндометриоз. Различные грани проблемы. ― СПб.: Эко-Вектор; 2017. ― 615 с.
  32. Elnashar A. Emerging treatment of endometriosis. Middle East Fertil Soc J. 2015;20(2):61−69. doi: 10.1016/j.mefs.2014.12.002.
  33. Oner G, Ozcelik B, Ozgun MT, et al. The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model. Hum Reprod. 2010;25(4):932−937. doi: 10.1093/humrep/deq016.

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