MOLECULAR MECHANISMS OF FORMATION OF CHRONIC PELVIC PAIN SYNDROME IN PATIENTS WITH EXTERNAL GENITAL ENDOMETRIOSIS: MARKERS AND TARGETS FOR DIAGNOSIS AND THERAPY (REVIEW)

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Abstract


This article systematizes the results of studies on the pathogenetic mechanisms of CPPS formation in patients with EGE. Pain is one of the severe clinical manifestations and complications of endometriosis. To ease the pain in patients with EGE is complex but urgent task. Long diagnostic search (mean period 5−8 years) leads to the formation of a persistent Autonomous pain syndrome associated with relapses of pain even after a com-prehensive treatment of patients (surgical and/or long-term hormonal). Patients with endometriosis suffer from mixed pain including neuropathic and nociceptive components which is proved by the example of expression in ectopic foci of specific biomarkers. Therefore, the question of early non-invasive diagnosis of endometriosis is very vital and can be solved by the development of a diagnostic panel consisting of biomarkers expressed by ectopic foci at the initial stage of the disease.


Daria E. Nikiforova

Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky

Author for correspondence.
Email: dashsemch@mail.ru
ORCID iD: 0000-0001-7516-5203

Russian Federation

MD.

1, Partizana Zheleznyaka street, 660022 Krasnoyarsk, Phone: +7 (495) 627-24-00.

SPIN-код: 1219-6470

Tatyana A. Makarenko

Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky

Email: makarenko7777@yandex.ru
ORCID iD: 0000-0001-7823-6222

Russian Federation

MD, PhD.

1, Partizana Zheleznyaka street, 660022 Krasnoyarsk, Phone: +7 (495) 627-24-00.

SPIN-код: 3133-7406

Alla B. Salmina

Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky

Email: allasalmina@mail.ru

Russian Federation

MD, PhD, Professor.

1, Partizana Zheleznyaka street, 660022 Krasnoyarsk, Phone: +7 (495) 627-24-00.

SPIN-код: 6504-7657

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