THE STRUCTURE OF PHARMACOTHERAPY OF ARTERIAL HYPERTENSION AND ADHERENCE IN YOUNG PATIENTS

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Abstract

Aim: To determine the indicators of adherence to drug therapy in young patients with arterial hypertension (АН) and the correlation between the indicators and therapy management.

Materials and methods: The study enrolled 514 patients aged 25 to 45 years diagnosed with essential hypertension. We studied the structure of antihypertensive pharmacotherapy and adherence to treatment using the Moriski−Green test and the original questionnaire. The patients were distributed depending on the degree of blood pressure increase, administered treatment, age, economic factor, and drug source.

Results: The adherence level by Moriski−Green test was 36.8%; according to the original questionnaire: high adherence level was 38.3%, incomplete adherence ― 33.7%, and poor adherence ― 28.0%. The monotherapy with ACE inhibitors predominated in the majority of cases; the fixed combinations were more typical for the treatment of the stage II AH, drug combinations ― for stage III AH. The highest therapy adherence was registered in patients with stage III AH receiving treatment with combinations of drugs in a single dosage form. The life quality of respondents and the drug source did not influence the adherence significantly.

Conclusion: In young patients with arterial hypertension, some features of treatment structure determine the therapy adherence.

About the authors

R. Ye. Tuleutayeva

Semey State Medical University

Email: raikhan65@mail.ru
ORCID iD: 0000-0002-0462-5230
Semey Kazakhstan

A. Ye. Musina

Semey State Medical University

Author for correspondence.
Email: musina_med@mail.ru
ORCID iD: 0000-0002-0114-5397
Semey Kazakhstan

N. A. Cebotarenko

Coalition on Rational Drug Use, World Health Organization

Email: corsumnews@gmail.com
ORCID iD: 0000-0003-4619-4421

Chisinau

Moldova, Republic of

A. R. Makhatova

Semey State Medical University

Email: asem_ram@mail.ru
ORCID iD: 0000-0003-4127-7279
Semey Kazakhstan

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