Periprosthetic Joint Infection as a Socio-Economic Problem of Modern Orthopedics

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Abstract

Periprosthetic joint infection is the main social and economic problem of modern orthopedics with a recurrence rate of chronic forms of up to 23.2–31.5%. The aim of this review is to inform various specialties doctors about the features of pathogenesis, etiology and treatment of periprosthetic joint infection, which significantly differ it from of other surgical site infections. The severity of infectious complications is due to the suppression of the patient’s immune system and microbial biofilms. Surgical treatment of periprosthetic joint infection involves debridement with preservation or removal of the implants, resection arthroplasty and arthrodesis. Today, in the treatment of more than 80% of cases of chronic infection, a two-stage approach is used, which allows to restore joint function after an average of 1.0–1.5 years. An integral part of the treatment of patients is high-dose, long-term and combined antibiotic therapy, which allows you to effectively deal with the leading pathogens of periprosthetic infection Staphylococcus aureus and S. epidermidis, the share of which is 46.5–57.5%. In the conditions of growing resistance of bacteria to antibiotics, the interest of researchers in the possibilities of using bacteriophages in the complex therapy of infections of bones and joints has increased. The cost of treatment exceeds the cost of “aseptic” joint replacement by 2–24 times and is characterized by a high level of disability and mortality of patients. Taking into account the numerous factors affecting the course and effectiveness of complex treatment of patients with periprosthetic infection, a multidisciplinary approach is currently considered the main component of success. The medical and social significance and high financial costs of treating patients with periprosthetic infection indicate the need for further research and the active implementation of effective scientific developments in the practical healthcare system.

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About the authors

Svetlana A. Bozhkova

Vreden National Medical Research Center of Traumatology and Orthopedics

Author for correspondence.
Email: clinpharm-rniito@yandex.ru
ORCID iD: 0000-0002-2083-2424

MD, PhD

Russian Federation, Saint Petersburg

Rashid M. Tikhilov

Vreden National Medical Research Center of Traumatology and Orthopedics

Email: rtikhilov@gmail.com
ORCID iD: 0000-0003-0733-2414

MD, PhD, Professor, Corresponding Member of the RAS

Russian Federation, Saint Petersburg

Vasily A. Artyukh

Vreden National Medical Research Center of Traumatology and Orthopedics

Email: artyukhva@mail.ru
ORCID iD: 0000-0002-5087-6081

MD, PhD

Russian Federation, Saint Petersburg

References

  1. Learmonth ID, Young C, Rorabeck C. The operation of the century: total hip replacement. Lancet. 2007;370(9597):1508–1519. doi: https://doi.org/10.1016/S0140-6736(07)60457-7
  2. Шубняков И.И., Тихилов Р.М., Денисов А.О., и др. Что изменилось в структуре ревизионного эндопротезирования тазобедренного сустава в последние годы? // Травматология и ортопедия России. — 2019. — Т. 25. — № 4. — С. 9–27. [Shubnyakov II, Tikhilov RM, Denisov AO, et al. What Has Changed in the Structure of Revision Hip Arthroplasty? Travmatologiya i ortopediya Rossii [Traumatology and orthopedics of Russia]. 2019;25(4):9–27. (In Russ.)] doi: https://doi.org/10.21823/2311-2905-2019-25-4-9-27
  3. Bozic KJ, Kamath AF, Ong K, et al. Comparative Epidemiology of Revision Arthroplasty: Failed THA Poses Greater Clinical and Economic Burdens Than Failed TKA. Clin Orthop Relat Res. 2015;473(6):2131–2138. doi: https://doi.org/10.1007/s11999-014-4078-8
  4. Kamath AF, Ong KL, Lau E, et al. Quantifying the Burden of Revision Total Joint Arthroplasty for Periprosthetic Infection. J Arthroplasty. 2015;30(9):1492–1497. doi: https://doi.org/10.1016/j.arth.2015.03.035
  5. Kurtz SM, Lau EC, Son MS, et al. Are We Winning or Losing the Battle With Periprosthetic Joint Infection: Trends in Periprosthetic Joint Infection and Mortality Risk for the Medicare Population. J Arthroplasty. 2018;33(10):3238–3245. doi: https://doi.org/10.1016/j.arth.2018.05.042
  6. Kurtz SM, Lau E, Watson H, et al. Economic Burden of Periprosthetic Joint Infection in the United States. J Arthroplasty. 2012;27(8Suppl):61–65.e1. doi: https://doi.org/10.1016/j.arth.2012.02.022
  7. Parvizi J, Shohat N, Gehrke T. Prevention of periprosthetic joint infection: new guidelines. Bone Joint J. 2017;99-B(4 Supple B):3–10. doi: https://doi.org/10.1302/0301-620X.99B4.BJJ-2016-1212.R1
  8. Середа А.П., Кочиш А.А., Черный А.А., и др. Эпидемиология эндопротезирования тазобедренного и коленного суставов и перипротезной инфекции в Российской Федерации // Травматология и ортопедия России. — 2021. — Т. 27. — № 3. — С. 84–93. [Sereda AP, Kochish AA, Cherny AA, et al. Epidemiology of Hip and Knee Arthroplasty and Periprosthetic Joint Infection in Russian Federation. Travmatologiya i ortopediya Rossii [Traumatology and Orthopedics of Russia]. 2021;27(3):84–93. (In Russ.)] doi: https://doi.org/10.21823/2311-2905-2021-27-3-84-93
  9. Springer BD, Cahue S, Etkin CD, et al. Infection burden in total hip and knee arthroplasties: an international registry-based perspective. Arthroplast Today. 2017;3(2):137–140. doi: https://doi.org/10.1016/j.artd.2017.05.003
  10. Masters EA, Trombetta RP, de Mesy Bentley KL, et al. Evolving concepts in bone infection: redefining “biofilm”, “acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”. Bone Res. 2019;7:20. doi: https://doi.org/10.1038/s41413-019-0061-z
  11. Declercq P, Neyt J, Depypere M, et al. Preoperative joint aspiration culture results and causative pathogens in total hip and knee prosthesis infections: mind the gap. Acta Clin Belg. 2020;75(4):284–292. doi: https://doi.org/10.1080/17843286.2019.1611718
  12. Holleyman RJ, Deehan DJ, Charlett A, et al. Does pre-operative sampling predict intra-operative cultures and antibiotic sensitivities in knee replacements revised for infection?: a study using the NJR dataset. Knee Surg Sports Traumatol Arthrosc. 2016;24(10):3056–3063. doi: https://doi.org/10.1007/s00167-015-3841-z
  13. Schulz P, Dlaska CE, Perka C, et al. Preoperative synovial fluid culture poorly predicts the pathogen causing periprosthetic joint infection. Infection. 2021;49(3):427–436. doi: https://doi.org/10.1007/s15010-020-01540-2
  14. Tande AJ, Patel R. Prosthetic Joint Infection. Clin Microbiol Rev. 2014;27(2):302–345. doi: https://doi.org/10.1128/CMR.00111-13
  15. Тихилов Р.М., Божкова С.А., Артюх В.А. Перипротезная инфекция в области крупных суставов конечностей // Ортопедия: клинические рекомендации. — М.: ГЭОТАР-Медиа, 2018. — С. 719–746. [Tikhilov RM, Bozhkova SA, Artyukh VA. Periproteznaya infektsiya v oblasti krupnykh sustavov konechnostey. Ortopediya: klinicheskiye rekomendatsii. Moscow: GEOTAR-Media; 2018. P. 719–746. (In Russ.)]
  16. McNally M, Sousa R, Wouthuyzen-Bakker M, et al. The EBJIS definition of periprosthetic joint infection. Bone Joint J. 2021;103-B(1):18–25. doi: https://doi.org/10.1302/0301-620X.103B1.BJJ-2020-1381.R1
  17. Ливенцов В.Н., Божкова С.А., Кочиш А.Ю., и др. Трудноизлечимая перипротезная инфекция тазобедренного сустава: результаты санирующих операций // Травматология и ортопедия России. — 2019. — Т. 25. — № 4. — С. 88–97. [Liventsov VN, Bozhkova SA, Kochish AYu, et al. Difficult-To-Treat Periprosthetic Hip Infection: Outcomes of Debridment. Travmatologiya i ortopediya Rossii [Traumatology and orthopedics of Russia]. 2019;25(4):88–97. (In Russ.)] doi: https://doi.org/10.21823/2311-2905-2019-25-4-88-97
  18. Преображенский П.М., Божкова С.А., Каземирский А.В. Расчет индекса коморбидности как фактора риска рецидива перипротезной инфекции после установки спейсера коленного сустава // Травматология и ортопедия России. — 2022. — Т. 28. — № 1. — С. 7–18. [Preobrazhensky PM, Bozhkova SA, Kazemirsky AV. Comorbidity Index as a Risk Factor of Knee PJI Recurrence After Spacer Implantation. Travmatologiya i ortopediya Rossii [Traumatology and Orthopedics of Russia]. 2022;28(1):7–18. (In Russ.)] doi: https://doi.org/10.17816/2311-2905-1718
  19. Hsieh PH, Lee MS, Hsu KY, et al. Gram-negative prosthetic joint infections: risk factors and outcome of treatment. Clin Infect Dis. 2009;49(7):1036–1043. doi: https://doi.org/10.1086/605593
  20. Cunningham DJ, Kavolus JJ, Bolognesi MP, et al. Specific Infectious Organisms Associated with Poor Outcomes in Treatment for Hip Periprosthetic Infection. J Arthroplasty. 2017;32(6):1984–1990.e5. doi: https://doi.org/10.1016/j.arth.2017.01.027
  21. Onyekwelu I, Yakkanti R, Protzer L, et al. Surgical Wound Classification and Surgical Site Infections in the Orthopaedic Patient. J Am Acad Orthop Surg Glob Res Rev. 2017;1(3):e022. doi: https://doi.org/10.5435/JAAOSGlobal-D-17-00022
  22. Fitzgerald RH. Infected Total Hip Arthroplasty: Diagnosis and Treatment. J Am Acad Orthopc Surg. 1995;3(5):249–262. doi: https://doi.org/10.5435/00124635-199509000-00001
  23. Zimmerli W, Sendi P. Orthopaedic biofilm infections. APMIS. 2017;125(4):353–364. doi: https://doi.org/10.1111/apm.12687
  24. Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-Joint Infections. N Engl J Med. 2004;351(16):1645–1654. doi: https://doi.org/10.1056/NEJMra040181
  25. Tsukayama DT, Estrada R, Gustilo RB. Infection after total hip arthroplasty. A study of the treatment of one hundred and six infections. J Bone Joint Surg Am. 1996;78(4):512–523. doi: https://doi.org/10.2106/00004623-199604000-00005
  26. Zimmerli W. Clinical presentation and treatment of orthopaedic implant-associated infection. J Intern Med. 2014;276(2):111–119. doi: https://doi.org/10.1111/joim.12233
  27. Svensson K, Rolfson O, Nauclér E, et al. Exchange of Modular Components Improves Success of Debridement, Antibiotics, and Implant Retention: An Observational Study of 575 Patients with Infection After Primary Total Hip Arthroplasty. JB JS Open Access. 2020;5(4):e20.00110. doi: https://doi.org/10.2106/JBJS.OA.20.00110
  28. Hipfl C, Mooij W, Perka C, et al. Unexpected low-grade infections in revision hip arthroplasty for aseptic loosening: a single-institution experience of 274 hips. Bone Joint J. 2021;103-B(6):1070–1077. doi: https://doi.org/10.1302/0301-620X.103B6.BJJ-2020-2002.R1
  29. Wignadasan W, Ibrahim M, Haddad FS. One- or two-stage reimplantation for infected total knee prosthesis? Orthop Traumatol Surg Res. 2023;109(1S):103453. doi: https://doi.org/10.1016/j.otsr.2022.103453
  30. Li Y, Zhang X, Ji B, et al. One-stage revision using intra-articular carbapenem infusion effectively treats chronic periprosthetic joint infection caused by Gram-negative organisms. Bone Joint J. 2023;105-B(3):284–293. doi: https://doi.org/10.1302/0301-620X.105B3.BJJ-2022-0926.R1
  31. Артюх В.А., Божкова С.А., Бояров A.A., и др. Эффективность одноэтапного ревизионного эндопротезирования при свищевой форме хронической перипротезной инфекции тазобедренного сустава // Травматология и ортопедия России. — 2021. — Т. 27. — № 2. — С. 9–22. [Artyukh VA, Bozhkova SA, Boyarov AA, et al. Efficiency of the One-Stage Revision Hip Arthroplasty in Chronic Periprosthetic Joint Infection with Sinus Tract. Travmatologiya i ortopediya Rossii [Traumatology and Orthopedics of Russia]. 2021;27(2):9–22. (In Russ.)] doi: https://doi.org/10.21823/2311-2905-2021-27-2-9-22
  32. Whiteside LA. Direct Intra-Articular Antibiotic Infusion for Resistant Organisms in the Treatment of Infection in Joint Arthroplasty. Seminars in Arthroplasty JSES. 2011;22(3):185–188. doi: https://doi.org/10.1053/j.sart.2011.07.013
  33. Материалы Второй международной согласительной конференции по лечению скелетно-мышечной инфекции: пер. с англ. / под общ. ред. Р.М. Тихилова, С.А. Божковой, И.И. Шубнякова. — СПб.: РНИИТО им. Р.Р. Вредена, 2019. — 314 с. [Proceedings of the Second international consensus Meeting on Musculoskeletal infection. Tikhilov RM, Bozhkova SA, Shubnyakov II. (eds). St. Petersburg: RNIITO im. R.R. Vredena; 2019. 314 р. (In Russ.)]
  34. Zimmerli W, Sendi P. Orthopedic Implant-Associated Infections. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 9th ed. Elsevier Inc.; 2020. Р. 1430–1442.e3.
  35. Akgün D, Perka C, Trampuz A, et al. Outcome of hip and knee periprosthetic joint infections caused by pathogens resistant to biofilm-active antibiotics: results from a prospective cohort study. Arch Orthop Trauma Surg. 2018;138(5):635–642. doi: https://doi.org/10.1007/s00402-018-2886-0
  36. Babis GC, Sakellariou VI, Pantos PG, et al. Two-Stage Revision Protocol in Multidrug Resistant Periprosthetic Infection Following Total Hip Arthroplasty Using a Long Interval Between Stages. J Arthroplasty. 2015;30(9):1602–1606. https://doi.org/10.1016/j.arth.2015.04.004
  37. Edelstein AI, Okroj KT, Rogers T, et al. Nephrotoxicity after the Treatment of Periprosthetic Joint Infection With Antibiotic-Loaded Cement Spacers. J Arthroplasty. 2018;33(7):2225–2229. doi: https://doi.org/10.1016/j.arth.2018.02.012
  38. Gathen M, Wimmer MD, Ploeger MM, et al. Comparison of two-stage revision arthroplasty and intramedullary arthrodesis in patients with failed infected knee arthroplasty. Arc Orthop Trauma Surg. 2018;138(10):1443–1452. doi: https://doi.org/10.1007/s00402-018-3007-9
  39. Cochran AR, Ong KL, Lau E, et al. Risk of Reinfection after Treatment of Infected Total Knee Arthroplasty. J Arthroplasty. 2016;31(9Suppl):156–161. doi: https://doi.org/10.1016/j.arth.2016.03.028
  40. Fehring KA, Abdel MP, Ollivier M, et al. Repeat two-stage exchange arthroplasty for periprosthetic knee infection is dependent on host grade. J Bone Joint Surg Am. 2017;99(1):19–24. doi: https://doi.org/10.2106/JBJS.16.00075
  41. Bozhkova S, Tikhilov R, Labutin D, et al. Failure of the first step of two-stage revision due to polymicrobial prosthetic joint infection of the hip. J Orthop Traumatol. 2016;17(4):369–376. doi: https://doi.org/10.1007/s10195-016-0417-8
  42. Божкова С.А., Ливенцов В.Н., Кочиш А.Ю., и др. Резекционная артропластика с пересадкой островкового мышечного лоскута у больных с перипротезной инфекцией // Хирургия. Журнал им. Н.И. Пирогова. — 2020. — № 2. — С. 32–38. [Bozhkova SA, Liventsov VN, Kochish AYu, et al. Resection Arthroplasty Using a Vastus Lateralis Muscle Flap in the treatment of patients with recurrent form of the hip prosthetic joint infection. Pirogov Russian Journal of Surgery = Khirurgiya. Zurnal im. N.I. Pirogova. 2020;2:32–38. (In Russ.)] doi: https://doi.org/10.17116/hirurgia202002132
  43. Куляба Т.А., Корнилов Н.Н. Ревизионная артропластика коленного сустава. — СПб.: НМИЦ ТО им. Р.Р. Вредена, 2021. — С. 278–319. [Kulyaba TA, Kornilov NN. Revizionnaya artroplastika kolennogo sustava. St. Petersburg: NMIC TO im. R.R. Vredena; 2016. Р. 278–319. (In Russ.)]
  44. Moura DL, Garruço A. Hip disarticulation - case series analysis and literature review. Rev Bras Ortop. 2017;52(2):154–158. doi: https://doi.org/10.1016/J.RBOE.2016.09.008
  45. Цискарашвили А.В., Мелихова Р.Э., Новожилова Е.А. Анализ шестилетнего мониторинга основных возбудителей перипротезной инфекции крупных суставов и их тенденция к резистентности // Гений ортопедии. — 2022. — Т. 28. — № 2. — С. 179–188. [Tsiskarashvili AV, Melikhova RE, Novozhilova E.A. Analysis of six-year monitoring of common pathogens causing periprosthetic joint infection of major joints and the tendency to resistance. Geniy Ortopedii. 2022;28(2):179–188. (In Russ.)] doi: https://doi.org/10.18019/1028-4427-2022-28-2-179-188
  46. Casenaz A, Piroth L, Labattut L, et al. Epidemiology and antibiotic resistance of prosthetic joint infections according to time of occurrence, a 10-year study. J Infec. 2022;85(5):492–498. doi: https://doi.org/10.1016/j.jinf.2022.07.009
  47. Villa JM, Pannu TS, Theeb I, et al. International Organism Profile of Periprosthetic Total Hip and Knee Infections. J Arthroplasty. 2021;36(1):274–278. doi: https://doi.org/10.1016/j.arth.2020.07.020
  48. Benito N, Franco M, Ribera A, et al. Time trends in the aetiology of prosthetic joint infections: a multicentre cohort study. Clinl Microbiol Infect. 2016;22(8):732.e1–732.e8. doi: https://doi.org/10.1016/j.cmi.2016.05.004
  49. Triffault-Fillit C, Ferry T, Laurent F, et al. Microbiologic epidemiology depending on time to occurrence of prosthetic joint infection: a prospective cohort study. Clinl Microbiol Infect. 2019;25(3):353–358. doi: https://doi.org/10.1016/j.cmi.2018.04.035
  50. Rizek C, Fu L, dos Santos LC, et al. Characterization of carbapenem-resistant Pseudomonas aeruginosa clinical isolates, carrying multiple genes coding for this antibiotic resistance. Ann Clin Microbiol Antimicrob. 2014;13:43. doi: https://doi.org/10.1186/s12941-014-0043-3
  51. Malhotra R, Bala K, Gautam D, et al. Mycobacterium abscessus Periprosthetic joint infection following bilateral Total Knee arthroplasty. IDCases. 2019;17:e00542. doi: https://doi.org/10.1016/j.idcr.2019.e00542
  52. Hantes ME, Papageorgiou F, Komnos GA. Stenotrophomonas maltophilia periprosthetic joint infection after reverse total shoulder arthroplasty. IDCases. 2020;21:e00796. doi: https://doi.org/10.1016/j.idcr.2020.e00796
  53. Kuttner H, Pfister S, Moriarty TF, et al. Periprosthetic Joint Infection with Actinomyces radingae May Lead to the Identification of a Neglected Source of Intraoperative Contamination. Arthroplas Today. 2022;18:181–184. doi: https://doi.org/10.1016/j.artd.2022.08.023
  54. Винклер Т., Трампуш А., Ренц Н., и др. Классификация и алгоритм диагностики и лечения перипротезной инфекции тазобедренного сустава // Травматология и ортопедия России. — 2016. — Т. 22. — № 1. — С. 33–45. [Winkler T, Trampush A, Renz H, et al. Classification and algorithm for the diagnosis and treatment of periprosthetic infection of the hip joint. Travmatologiya i ortopediya Rossii [Traumatology and Orthopedics of Russia]. 2016;22(1):33–45. (In Russ.)] doi: https://doi.org/10.21823/2311-2905-2016-0-1-33-45
  55. Ferry T, Kolenda C, Briot T, et al. Past and Future of Phage Therapy and Phage-Derived Proteins in Patients with Bone and Joint Infection. Viruses. 2021;13(12):2414. doi: https://doi.org/10.3390/v13122414
  56. Tkhilaishvili T, Winkler T, Müller M, et al. Bacteriophages as Adjuvant to Antibiotics for the Treatment of Periprosthetic Joint Infection Caused by Multidrug-Resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2019;64(1):e00924-19. doi: https://doi.org/10.1128/AAC.00924-19
  57. Ferry T, Leboucher G, Fevre C, et al. Salvage Debridement, Antibiotics and Implant Retention (“DAIR”) With Local Injection of a Selected Cocktail of Bacteriophages: Is It an Option for an Elderly Patient with Relapsing Staphylococcus aureus Prosthetic-Joint Infection? Open Forum Infect Dis. 2018;5(11):ofy269. doi: https://doi.org/10.1093/ofid/ofy269
  58. Ferry T, Kolenda C, Batailler C, et al. Phage Therapy as Adjuvant to Conservative Surgery and Antibiotics to Salvage Patients With Relapsing S. aureus Prosthetic Knee Infection. Front Med (Lausanne). 2020;7:570572. doi: https://doi.org/10.3389/fmed.2020.570572
  59. Гордина Е.М., Божкова С.А., Смирнова Л.Н. Антибактериальное и антибиопленочное действия бактериофагов в отношении Klebsiella pneumoniae и Pseudomonas aeruginosa, выделенных от пациентов с ортопедической инфекцией // Тихоокеанский медицинский журнал. — 2023. — № 1 (91). — С. 59–63. [Gordina YM, Bozhkova SA, Smirnova LN. Anti-bacterial and anti-biofilm activity of bacteriophages against Klebsiella pneumoniae and Pseudomonas aeruginosa isolated from orthopedic patients. Tikhookeanskiy meditsinskiy zhurnal. 2023;1(91):59–63. (In Russ.)] doi: https://doi.org/10.34215/1609-1175-2023-1-30-34
  60. Hemmati F, Rezaee MA, Ebrahimzadeh S, et al. Novel Strategies to Combat Bacterial Biofilms. Mol Biotechnol. 2021;63(7):569–586. doi: https://doi.org/10.1007/s12033-021-00325-8
  61. Haddad FS, Ngu A, Negus JJ. Prosthetic Joint Infections and Cost Analysis? Adv Exp Med Biol. 2017:971:93–100. doi: https://doi.org/10.1007/5584_2016_155
  62. Sinagra ZP, Davis JS, Lorimer M, et al. The accuracy of reporting of periprosthetic joint infection to the Australian Orthopaedic Association National Joint Replacement Registry. Bone Jt Open. 2022;3(5):367–374. doi: https://doi.org/10.1302/2633-1462.35.BJO-2022-0011.R1
  63. Puhto T, Puhto AP, Vielma M, et al. Infection triples the cost of a primary joint arthroplasty. Infect Dis (Lond). 2019;51(5):348–355. doi: https://doi.org/10.1080/23744235.2019.1572219
  64. Alp E, Cevahir F, Ersoy S, et al. Incidence and economic burden of prosthetic joint infections in a university hospital: A report from a middle-income country. J Infec Public Health. 2016;9(4):494–498. doi: https://doi.org/10.1016/j.jiph.2015.12.014
  65. Serrier H, Julien C, Batailler C, et al. Economic Study of 2-Stage Exchange in Patients with Knee or Hip Prosthetic Joint Infection Managed in a Referral Center in France: Time to Use Innovative(s) Intervention(s) at the Time of Reimplantation to Reduce the Risk of Superinfection. Front Med (Lausanne). 2021;8:552669. doi: https://doi.org/10.3389/fmed.2021.552669
  66. Natsuhara KM, Shelton TJ, Meehan JP, et al. Mortality during Total Hip Periprosthetic Joint Infection. J Arthroplasty. 2019;34(7S):S337–S342. doi: https://doi.org/10.1016/j.arth.2018.12.024
  67. Broom J, Broom A, Kenny K, et al. Multidisciplinary team meetings in prosthetic joint infection management: A qualitative study. Infect Dis Health. 2023:28(3):145–150. doi: https://doi.org/10.1016/j.idh.2023.01.002
  68. Carlson VR, Dekeyser GJ, Certain L, et al. Clinical Experience with a Coordinated Multidisciplinary Approach to Treating Prosthetic Joint Infection. Arthroplast Today. 2020;6(3):360–362. doi: https://doi.org/10.1016/j.artd.2020.05.003
  69. Ferry T, Seng P, Mainard D, et al. The CRIOAc healthcare network in France: A nationwide Health Ministry program to improve the management of bone and joint infection. Orthop Traumatol Surg Res. 2019;105(1):185–190. doi: https://doi.org/10.1016/j.otsr.2018.09.016
  70. Laurent E, Lemaignen A, Gras G, et al. Multidisciplinary team meeting for complex bone and joint infections diagnosis: The PHICTOS study. Rev Epidemiol Sante Publique. 2019;67(3):149–154. doi: https://doi.org/10.1016/J.RESPE.2019.01.121
  71. Vuorinen M, Mäkinen T, Rantasalo M, et al. Effect of a multidisciplinary team on the treatment of hip and knee prosthetic joint infections: a single-centre study of 154 infections. Infect Dis (Lond). 2021;53(9):700–706. doi: https://doi.org/10.1080/23744235.2021.1925341
  72. Li C, Renz N, Trampuz A. Management of Periprosthetic Joint Infection. Hip Pelvis. 2018;30(3):138–146. doi: https://doi.org/10.5371/hp.2018.30.3.138

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