Status Indicators of Lipid Peroxidation and Endogenous Intoxication in Lung Cancer Patients

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Abstract

Background: Problems of optimization diagnosis methods and prognosis for lung cancer remain unsolved. Lung cancer occupied the leading positions among cancer diseases.

Aims: Establishing change patterns in the parameters of endogenous intoxication and lipid peroxidation in the saliva of patients with lung cancer depending on the histologic type of tumor.

Materials and methods: The case-control study enrolled 516 men, who were divided into 3 groups: main (lung cancer, n=256), comparison group (non-malignant lung diseases, n=60), and control group (relatively healthy, n=200). Questioning and biochemical saliva study were carried out to all participants. Patients of the main group and the comparison group were hospitalized for surgical treatment, after which underwent the histological verification of the diagnosis. We used the spectrophotometric methods of investigation of parameters of lipid peroxidation and endogenous intoxication. Between-group differences were evaluated by nonparametric tests.

Results: Malondialdehyde as a product of lipid peroxidation is a little informative result. For more information it is necessary to determine the individual fractions of middle toxins count distribution ratio 280/254 nm, as well as to take into account the level of conjugated diene, triene conjugates, and Schiff bases. The following changes are observed at the transition from the control group to the comparison group, and then to the main: increased levels of triene conjugates and Schiff bases, as well as malondialdehyde. At the same time we detected the reduction in the level of diene conjugates, which confirms the fact of the increase in the oxidative stress process associated with benign diseases and lung cancer. In addition, there is a decrease in the content of individual fractions of middle toxins, but 280/254 nm partition coefficient growth is observed.

Conclusions: The findings support the hypothesis of the association processes of lipid peroxidation and endogenous intoxication with the development of lung cancer. It confirmed the dependence of these parameters on the histological type of tumor, the presence / absence and the degree of prevalence of remote and regional metastasis.

About the authors

L. V. Belskaya

Omsk State Technical University, Omsk, Russian Federation

Author for correspondence.
Email: ludab2005@mail.ru
ORCID iD: 0000-0002-6147-4854

кандидат химических наук, директор по науке ООО «ХимСервис», доцент кафедры химической технологии и биотехнологии Омского государственного технического университета Адрес: 644050, Омск, Проспект Мира, д. 11, тел.: +7 (913) 641-35-77

Россия

V. K. Kosenok

ChemService, Omsk, Russian Federation

Omsk State Medical University, Omsk, Russian Federation

Email: vic.kos_senok@mail.ru
ORCID iD: 0000-0002-2072-2460

доктор медицинских наук, профессор, академик РАМТН, заведующий кафедрой онкологии с курсом лучевой терапии Омского государственного медицинского университета Адрес: 644013, Омск, ул. Завертяева, д. 9, корп. 1, тел.: +7 (3812) 60-17-46

Z. Massard

University Hospital of Strasbourg, Strasbourg, France

Email: gilbert.massard@chru-strasbourg.fr

профессор, главный онколог Страсбургского университета, заведующий отделением торакальной хирургии и трансплантологии, академик РАМН, член Американской ассоциации торакальной хирургии Адрес: 67091, Страсбург, ул. Порт дё Лопиталь, ВР 426

A. A. Zav’yalov

Federal State Budgetary Scientifi c Institution «Tomsk Саnсеr Rеsеаrсh Institute», Tomsk, Russian Federation

Email: Azav06@mail.ru

доктор медицинских наук, профессор, ведущий научный сотрудник Томского национального исследовательского медицинского центра РАН Адрес: 634050, Томск, пер. Кооперативный, д. 5, тел.: +7 (3822) 41-80-89

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