HYDROGEN SULFIDE AS A THIRD ESSENTIAL GAS MOLECULE IN LIVING TISSUES

Cover Page


Cite item

Full Text

Abstract

The data of foreign studies over the last 15 years devoted to endogenous synthesis and biological role of hydrogen sulfide in micromolar quantities which complemented the already two well-known gas transmitters — OH and NO are presented in this review. Despite the short period since the physiological properties of hydrogen sulfide were opened (about 20 years) it was found that this gas transmitter plays a key role in the regulation of nerve (neural signal transmission), cardiovascular (relaxation of smooth muscles), immune (anti-inflammatory and cytoprotective agent) sensory, gastrointestinal (output of insulin) systems and in the metabolism of various organs. Currently the role of H2S in the pathogenesis of different diseases, neurodegenerative diseases, diabetes, heart failure) is being studying. The developments of drugs that act as either exogenous donors H2S or blockers of the biosynthesis of H2S are promising. With consideration the fact that H2S is a representative of non-synaptic way of intercellular communication based on diffusion of molecules of inorganic compounds in the intercellular space in all directions and effect on distant from their place of formation non- synaptic receptors it is suggested to use exogenous H2S in strict proportion for the treatment of a number of human diseases.

 

About the authors

S. I. Kolesnikov

Scientific Center of the Problems of Family Health and Human Reproduction, Irkutsk, Russian Federation

Author for correspondence.
Email: sikolesnikov2012@gmail.com

доктор медицинских наук, академик РАН, главный научный сотрудник НЦ ПЗСРЧ, заслуженный деятель науки РФ
Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76 36

Россия

B. Ya. Vlasov

Scientific Center of the Problems of Family Health and Human Reproduction, Irkutsk, Russian Federation

Email: vlasov.vlabor@yandex.ru

доктор медицинских наук, профессор, старший научный сотрудник лаборатории физиологии и патологии эндокринной системы НЦ ПЗСРЧ
Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36, 20-73-67

Россия

L. I. Kolesnikova

Scientific Center of the Problems of Family Health and Human Reproduction, Irkutsk, Russian Federation

Email: iphr@sbamsr.irk.ru

доктор медицинских наук, член-корреспондент РАН, профессор, директор НЦ ПЗСРЧ
Адрес: 664003, Иркутск, ул. Тимирязева, д. 16, тел.: +7 (3952) 20-76-36

Россия

References

  1. Wang R. Signal transduction and the gasotransmitters: NO, CO and H2S in biology and мedicine. Totowa: Humana Press. 2004. 392 p.
  2. Tripatara P., Patel N.S., Collino M., Gallicchio M., Kieswich J., Castiglia S. Generation of endogenous hydrogen sulfide by cystathionine gammalyase limits renal ischemia/reperfusion injury and dysfunction. Lab. Invest. 2008; 88: 1038–1048.
  3. Carsten A.W. Hydrogen sulfide: a new gaseous signal molecule and blood pressure regulator J. Nephrol. 2009; 22: 173–176.
  4. Fiorucci S., Distrutti E., Cirino G., Wallace J.L. The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver. J. Gastroenterol. 2006; 131: 259–271.
  5. Abe K., Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J. Neurosci. 1996; 16: 1066–1071.
  6. Kimura Y., Kimura H. Hydrogen sulfide protects neurons from oxidative stress. FASEB J. 2004; 18: 1165–1167.
  7. Mathaia J.C., Missnerb A., Ku P. et al. No facilitator required for membrane transport of hydrogen sulfide. Proc. Natl. Acad. Sci. U.S.A. 2009; 106: 16633–16638.
  8. Li L., Moore P.K. Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air? Trends Pharmacol. Sci. 2008; 29: 84–90.
  9. Reiffenstein R.J., Hulbert W.C. Toxicology of hydrogen sulfide. Annu. Rev. Pharmacol. Toxicol. 1992; 32: 109–134.
  10. Lowicka E., Beltowski J. Hydrogen sulfide — the third gas of interest for pharmacologists. Pharmacol. Reports. 2007; 59: 4–24.
  11. Wagner C.A. Hydrogen sulfide: a new gaseous signal molecula and blood pressure regulator J. Nephrol. 2009; 22: 173–176.
  12. Kamoun P. Endogenous production of hydrogen sulfide in mammals. Amino Aсids. 2004; 26: 243–254.
  13. Stipanuk M.H., Beck P.W. Characterization of the enzymic capacity for cysteine desulphydration in liver and kidney of the rat. Biochem. J. 1982; 206: 267–277.
  14. Shibuya N., Milkanai Y., Kimura Y., Nagahara N., Kimura H. Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide. J. Biochem. Adv. Access. 2009; 146: 623–626.
  15. Whiteman M., Armstrong J.S., Chu S.H., Jia–Ling S., Wong B.S., Cheung N.S., Halliwell B. The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite «scavenger»? J. Neurochem. 2004; 90: 765–768.
  16. Yan S.K., Chang T., Wang H., Wu L., Wang R., Meng Q.H. Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 2006; 361: 485–491.
  17. Rinaldi L., Gobbi G., Pambianco M., Micheloni C., Mirandola P., Vitale M. Hydrogen sulfide prevents apoptosis of human PMN via inhibition of p38 and caspase 3. Lab. Invest. 2006; 86: 391–397.
  18. Qu K., Lee S. W., Bian J.S., Low, C.M.; Wong, P.T. Hydrogen sulfide: neurochemistry and neurobiology. Neurochem. Int. 2008; 52: 155–165.
  19. Kimura H., Nagai Y., Umemura K., Kimura Y. Physiological roles of hydrogen sulfide: Synaptic modulation, neuroprotection, and smooth muscle relaxation. Antioxid. Redox. Signal. 2005; 7: 795–803.
  20. Antonini E., Brunori M. Hemoglobin and myoglobin in their reactions with ligands. Amsterdam: North-Holland Publishing. 1971. 393 р.
  21. Yonetani T., Tsuneshige A., Zhou Y., Chen X. Electron paramagnetic resonance and oxygen binding studies of anitrosyl hemoglobin: a novel oxygen carrier having NO assisted allosteric functions. J. Biol. Chem. 1998; 273: 20323–20333.
  22. Mustafa A.K., Gadalla M.M., Snyder S.H. Signaling by gasotransmitters. Sci. Signal. 2009; 2: 2.
  23. Hill B.C., Woon T.C., Nicholls P., Peterson J., Greenwood C., Thomson A.J. Interactions of sulphide and other ligands with cytochrome c oxidase. An electron paramagnetic resonance study. Biochem. J. 1984; 224: 591–600.
  24. Yang G., Cao K., Wu L., Wang R. Cystathionine γ-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/ WAK–1. J. Biol. Chem.2004; 279: 49199–49205.
  25. Beltowski J. Hydrogen sulfide as a biologically active mediator in the cardiovascular system. Postepy. Hig. Med. Dosw. 2004; 58: 285–291.
  26. Geng B., Yang J., Qi Y., Zhao J., Peng Y., Du J., Tang C. H2S generated by heart in rat and its effects on cardiac function. Biochem. Biophys. Res. Commun. 2004; 313: 362–368.
  27. Smith R.P. A short history of hydrogen sulfide. American Scientist. 2010; 98: 6.
  28. Skovgaard N., Gouliaev A., Aalling M., Simonsen U. The Role of Endogenous H2S in Cardiovascular Physiology. Curr. Pharm. Biotechnol. 2011; 12: 1385–1393.
  29. Wang R. Hydrogen sulfide: the third gasotransmitter in biology and medicine. Antioxid. Redox. Signal. 2010; 12: 1061–1064.
  30. John L.W. Physiological and pathophysiological roles of hydrogen sulfide in the gastrointestinal tract. Antiox. Redox. Signal. 2010; 12: 1125–1133.
  31. Wang R. Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J. 2002; 16: 1792–1798.
  32. Jang G., Wu L., Liang W., Wang R. Direct stimulation of K (ATP) channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Mol. Pharmacol. 2005; 68: 1757–1817.
  33. Zhao W., Wang R. H2S induced vasorelaxation and underlying cellular and molecular mechanisms. Am. J. Physiol. Heart. Circ. Physiol. 2002; 283: 474–480.
  34. Zhao W., Zhang J., Lu Y., Wang R. The vasorelaxant effect of H2S as a novel endogenous gaseous K (ATP) channel opener. EMBO J. 2001; 20: 6008–6016.
  35. Lavu M., Bhushan S., Lefler D.J. Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic protection. Clin. Sci. 2011; 120: 219–229.
  36. Nakao A., Sugimoto R., Billiar T. R., McCurry K. R. Therapeutic antioxidant medical gas. J. Clin. Biochem. Nutr. 2009; 44: 1–13.
  37. Wei G., Ze-yu C., Yi–zhun Z. Hydrogen sulfide and translational medicine. Acta Pharmacol. Sinica. 2013; 34: 1284–1291.
  38. Warenycia M.W., Steele J.A., Karpinski E., Reiffenstein R.J. Hydrogen sulfide in combination with taurine or cysteic acid reversibly abolishes sodium currents in neuroblastoma cells. Neurotoxicology. 1989; 10: 191–199.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2015 "Paediatrician" Publishers LLC



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies