Epigenetic Aspects of Osteoporosis

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Abstract

This review describes the epigenetic regulation of osteoblastogenesis and osteoclastogenesis and its future implementation in the diagnosis and treatment of osteoporosis. A considerable part of the review is dedicated to the microRNAs (miRNAs). miRNAs are small regulatory factors that regulate gene expression, by post-transcriptional regulation of genes playing an important role in numerous cellular processes, including cell differentiation and apoptosis. Recently, a number of studies have revealed that miRNAs participate in bone homeostasis and their role in the pathogenesis of osteoporosis is practically evident. In this review, we highlight the miRNAs involved in bone remodelling and their roles in osteoporosis. miRNAs are stable molecules which make them promising potential markers for bone remodeling and osteoporosis.

About the authors

T. A. Grebennikova

National Endocrine Research Centre, Moscow, Russian Federation

Author for correspondence.
Email: grebennikova@hotmail.com

ординатор отделения нейроэндокринологии и остеопатий ФГБУ «Эндокринологический научный центр» Минздрава России Адрес: 117036, Москва, ул. Дмитрия Ульянова, д. 11

Россия

Zh. E. Belaya

National Endocrine Research Centre, Moscow, Russian Federation

Email: jannabelaya@gmail.com

доктор медицинских наук, главный научный сотрудник, заведующая отделением нейроэндокринологии и остеопатий ФГБУ «Эндокринологический научный центр» Минздрава России Адрес: 117036, Москва, ул. Дмитрия Ульянова, д. 11, тел.: +7 (495) 668-20-79

Россия

L. Ya. Rozhinskaya

National Endocrine Research Centre, Moscow, Russian Federation

Email: rozhinskaya@rambler.ru

доктор медицинских наук, главный научный сотрудник отделения нейроэндокринологии и остеопатий ФГБУ «Эндокринологический научный центр» Минздрава России Адрес: 117036, Москва, ул. Дмитрия Ульянова, д. 11, тел.: +7 (495) 668-20-79

Россия

G. A. Mel'nichenko

National Endocrine Research Centre, Moscow, Russian Federation

Email: teofrast2000@mail.ru

заместитель директора по научной работе, директор института клинической эндокринологии ФГБУ «Эндокринологический научный центр» Минздрава России, академик РАН Адрес: 117036, Москва, ул. Дмитрия Ульянова, д. 11, тел.: +7 (499) 124-43-00

Россия

I. I. Dedov

National Endocrine Research Centre, Moscow, Russian Federation

Email: dedov@endocrincentr.ru

директор ФГБУ «Эндокринологический научный центр» Минздрава России, академик РАН, Президент Российской ассоциации эндокринологов Адрес: 117036, Москва, ул. Дмитрия Ульянова, д. 11, тел.: +7 (499) 124-43-00

Россия

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