AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM: PROBLEM STATEMENT AND PROSPECTS

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Abstract

This review highlights the achievements in the field of autoimmune diseases of the nervous system over the last 15 years. It became possible to deepen the understanding of medical and social significance of these diseases, form the concept of nosologic unit heterogeneity, describe new and atypical forms of demyelinating diseases of the central and peripheral nervous system, autoimmune diseases of the neuromuscular synapse. Also, it is important to mention, that the new antigens were identified, the diagnostic panel of autoantibodies was developed and put into practice. Furthermore, the clinical practice guidelines for the diagnosis and management of patients were developed, the new drugs were tested and included in these guidelines. The scientists of the biggest Russian neurological centre, Research Centre of Neurology (Moscow), developed a vaccine for immunotherapy of multiple sclerosis, studied pathomorphosis of Guillain–Barre syndrome, specified the components of its pathogenesis, improved the programs of pathogenetic therapy, which led to the decrease in mortality from 30 to 3%, helped to decrease the AVL period by 2 times, hasten the recovery of independent walking by 2.5 times. Nowadays different biomarkers of diseases of the central and peripheral nervous system are studied and modern technologies in neurorehabilitation are applied.

 

About the authors

M. A. Piradov

Research Centre of Neurology, Moscow, Russian Federation

Author for correspondence.
Email: dir@neurology.ru
PhD, professor, corresponding member of RAS, Director of Research Centre of Neurology. Address: 80, Volokolamskoe Highway, Moscow, 125367, tel.: +7 (495) 290-20-03 Russian Federation

N. A. Suponeva

Research Centre of Neurology, Moscow, Russian Federation

Email: reneurology@neurology.ru
PhD, Head of the Department of Neurorehabilitation and Physiatrics of Research Centre of Neurology. Address: 80, Volokolamskoe Highway, Moscow, 125367, tel.: +7 (495) 290-20-03 Russian Federation

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