THE ROLE OF ALFA-2-BETA-ADRENORECEPTOR IN DEVELOPMENT OF VENTRICULAR CONDUCTION DISTURBANCE

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Abstract


Background: The purpose of this study was to investigate association between the genetic polymorphism I/D of gene α2β-adrenoreceptor (ADRA2B) and hereditary disorders of ventricular conduction. Patients and methods: In this study, 102 people with complete left bundle branch block (45,71±1,852 years) — 46 females and 56 males, and 86 people with complete right bundle branch block (34,59±1,86 years) — 41 females and 45 males. The study was approved by Ethic Committee of the KrasSMU. All participants were included in the study after written informed consent form. Cardiological examination included clinical examination, electrocardiography, echocardiography, Holter monitoring, stresstest, koronaroangiografy and radionuclide method of a myocardium and molecular and genetic researches. Results: Statistically, significant prevalence of a homozygous genotype of DD on rare allele gene ADRA2B in both groups in comparison with group of control is established. The reliable dominance of the homozygous rare genotypes (D allele) of gene ADRA2B were detected in all groups. Conclusion: Polymorphism DD of a gene ADRA2B is a genetic predictor of predisposition to the blockade of the right and left bundle branch block.


About the authors

S. Yu. Nikulina

Voino-Yasenetsky Krasnoyarsk State Medical University, Russian Federation

Author for correspondence.
Email: nicoulina@mail.ru

Russian Federation

PhD, professor, Head of the Department of Intestinal Diseases № 1 of V.F.Voino-Yasenetskii Krasnoyarsk State Medical University. Address: 3G, Partizana Zheleznyaka Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 292-53-79

S. S. Tret'yakova

Voino-Yasenetsky Krasnoyarsk State Medical University, Russian Federation

Email: tretyakova-svet@mail.ru

Russian Federation resident physician of the Department of Intestinal Diseases № 1 of V.F.Voino-Yasenetskii Krasnoyarsk State Medical University. Address: 3G, Partizana Zheleznyaka Street, Krasnoyarsk, RF, 660022; tel.: +7 (983) 151-97-89,

V. N. Maksimov

Institute of Internal Medicine, Novosibirsk, Russian Federation

Email: rootnii@iimed.ru

Russian Federation

Head of the Laboratory of Molecular Genetic Study of Therapeutic diseases of Research Institute of Therapy and Preventive Medicine.  Address: 175/1, Borisa Bogatkova Street, Novosibirsk, RF, 630089; tel.: +7 (383) 373-09-81

M. I. Voevoda

Institute of Internal Medicine, Novosibirsk, Russian Federation

Email: voevodami@mail.ru

Russian Federation PhD, professor, correspondent member of RAMS, Director of Research Institute of Therapy and Preventive Medicine. Address: 175/1, Borisa Bogatkova Street, Novosibirsk, RF, 630089; tel.: +7 (383) 373-09-81

V. N. Chernov

Voino-Yasenetsky Krasnoyarsk State Medical University, Russian Federation

Email: chernovortstom@mail.ru

Russian Federation

MD, assistant of the Department of Dental orthopedics of V.F.Voino-Yasenetskii Krasnoyarsk State Medical University. Address: 3G, Partizana Zheleznyaka Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 293-27-57,

A. A. Chernova

Voino-Yasenetsky Krasnoyarsk State Medical University, Russian Federation

Email: anechkachernova@yandex.ru

Russian Federation

MD, assistant professor of the Department of Intestinal Diseases № 1 of V.F.Voino-Yasenetskii Krasnoyarsk State Medical University. Address: 3G, Partizana Zheleznyaka Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 241-56-96

References

  1. Heinonen P., Koulu M., Pesonen U., Karvonen M., Rissanen A., Laakso M., Valve R., Uusitupa M., Scheinin M. Identification of a three-amino acid deletion in the alpha-2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. J. Clin. Endocr. Metab. 1999; 84 (7): 2429–2433.
  2. Suzuki N., Matsunaga T., Nagasumi K., Yamamura T., Shihara N., Moritani T., Ue H., Fukushima M., Tamon A., Seino Y., Tsuda K., Yasuda K. Аlpha(2B)-adrenergic receptor deletion polymorphism associates with autonomic nervous system activity in young healthy Japanese. J. Clin. Endocr. Metab. 2003; 88 (3): 1184–1187.
  3. Chen Q.J., Lu L., Jin C., Wang L.J., Zhang R.Y., Zhang Q., Hu J., Yang Z.K., Shen W.F. Insertion/insertion genotype of α(2B)-adrenergic receptor gene polymorphism is associated with silent myocardial ischemia in patients with type 2 diabetes mellitus. Clin. Biochem. 2010; 43 (15): 1201–1204.
  4. Fava C., Montagnana M., Guerriero M., Almgren P., von Wowern F., Minuz P., Melander O. Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome. J. Hypertens. 2009; 27 (9): 1794–1803.
  5. Li L.H., Li Y., Wen Y., Wang J.G. Anthropometric and metabolic phenotypes in relation to the ADRA2B deletion/insertion polymorphism in Chinese population. J. Hypertens. 2008; 26 (11): 2161–2167.
  6. Laaksonen D.E., Siitonen N., Lindstr m J., Eriksson J.G., Reunanen P., Tuomilehto J., Uusitupa M. Physical activity, diet, and incident diabetes in relation to an ADRA2B polymorphism. Med. Sci. Sports Exerc. 2007; 39 (2): 227–232.
  7. Nikulina S.Yu., Shul'man V.A., Chernova A.A., Dudkina K.V., Nikulin D.A., Voevoda M.I., Maksimov V.N. Sib. med. obozrenie = Siberian medical review. 2009; 59(5): 23–25.
  8. Shul'man V.A., Nikulina S.Yu., Dudkina K.V., Voevoda M.I., Maksimov V.N., Aksyutina N.V., Chernova A.A., Zlodeev K.V., Allakhverdyan A.A. Sib. med. obozrenie = Siberian medical review. 2010; 62(2): 25–28.
  9. Muszkat M., Kurnik D., Sofowora G.G., Solus J., Xie H.G., Harris P.A., Williams S.M., Wood A.J., Stein C.M. Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha] 2B-adrenergic receptor subtype. Hypertens. 2010; 2 (28): 278–284.
  10. Duling L.C., Cherng T.W., Griego J.R., Perrine M.F., Kanagy N.L. Loss of alpha2B-adrenoceptors increases magnitude of hypertension following nitric oxide synthase inhibition. Am. J. Physiol. Heart. Circ. Physiol. 2006; 291 (5): 2403–2408.
  11. Kintsurashvili E., Shenouda S., Ona D., Ona L., Ahmad S., Ravid K., Gavras I., Gavras H. Hypertension in transgenic mice with brainselective overexpression of the alpha(2B)-adrenoceptor. Am. J. Hypertens. 2009; 22 (11): 41–45.
  12. Ham J., Rees D.A. The adenosine a2b receptor: its role in inflammation. Endocr. Metab. Immune Disord. Drug Targets. 2008; 8 (4): 244–254.
  13. Zhang H.F., Li X.L., Xie S.F., Zhu J., Wang Z.Z., Liang L.R., Cao K.J., De W., Yuan L., Huang J. ADRA2B gene insertion/deletion polymorphism and artery compliance. Chin. Med. J. (Engl). 2005; 118 (21): 1797–1802.

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