GENETIC DEPENDENCY OF BLOOD PRESSURE AND HEART RATE IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBESITY

Cover Page


Cite item

Full Text

Abstract

Background: The aim of the study was to determine the effect of gene polymorphisms Arg389Gly ADRβ1 gene and T393C gene GNAS1 on the level of heart rate (HR), systolic and diastolic blood pressure (SBP and DBP) in hypertensive patients according to body mass index (BMI). Patients and methods: The study involved 166 patients with hypertension and 90 healthy individuals. Patients of the main group was divided according to BMI into three subgroups: I subgroup — with normal body weight, II subgroup — overweight, III subgroup — obesity. Gene polymorphism is determined using polymerase chain reaction and subsequent analysis of restriction fragments. Results: Patients from subgroups II and III, who had presence of genotypes Arg389Arg, Arg389Gly, had higher HR, SBP than in patients with genotype Gly389Gly (p =0,010 and p =0,001; p =0,010 and p =0,001, respectively). In the analysis of DBP, the dependence of its level of polymorphism Arg389Gly of ADRβ1 gene was found only in I subgroup (p <0,001). During the analysis of polymorphism T393C of GNAS1 gene only in patients from III subgroup was found a higher heart rate in patients with T393T genotype relatively to C393C genotype, but this difference was not statistically significant (p =0,191). Conclusion: There is a direct correlation between HR and SBP in hypertensive patients with overweight and obesity from polymorphism Arg389Gly of ADRβ1 gene, in hypertensive patients with normal body weight from this polymorphism depends DBP. Clinical manifestations of hypertension do not depend on polymorphism T393C of GNAS1 gene.

About the authors

I. A. Dudchenko

Sumy State University, Ukraine

Email: dudchenko_irina@mail.ua

postgraduate of the Department of Internal Medicine Postgarduate Education of Sumy State University. Address: 2, Rimskogo-Korsakova Street, Sumy, Ukraine, 40000; tel.: +38 (0542) 77-57-05

Ukraine

L. N. Pristupa

Sumy State University

Author for correspondence.
Email: therapiasumdu@mail.ru
PhD, professor, Head of the Department of Internal Medicine Postgarduate Education of Sumy State University Ukraine

A. V. Ataman

Sumy State University, Ukraine

Email: ataman_av@mail.ru

professor, Head of the Department of Physiology and Pathophysiology of Sumy State University. Address: 2, Rimskogo-Korsakova Street, Sumy, Ukraine, 40000; tel.: +38 (0542) 654-063

Ukraine

V. Yu. Garbuzova

Sumy State University, Ukraine

Email: vikgarbuzova@yandex.ru
PhD, professor of the Department of Physiology and Pathophysiology of Sumy State University. Address: 2, Rimskogo-Korsakova Street, Sumy, Ukraine, 40000; tel.: +38 (0542) 654-063 Ukraine

References

  1. Cadman P.E., O’Connor D.T. Curr. Opin Nephrol. Hypertension. 2003; 12: 61–70.
  2. Tsioufis C., Kordalis A., Flessas D., Anastasopoulos I., Tsiachris D., Papademetriou V., Stefanadis C. Int. J. Hypertens. 2011; 2011: 642416.
  3. DiBona G.F, Esler M. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010; 298 (2): 245–253.
  4. Grassi G., Seravalle G., Trevano F.Q., Dell’oro R., Bolla G., Cuspidi C., Arenare F., Mancia G. Hypertension. 2007; 50 (3): 537–542.
  5. Smith P.A., Graham L.N., Mackintosh A.F., Stoker J.B., Mary D.A. Am. J. Hypertens. 2004;17 (3): 217–222.
  6. Kazak L.I., Chekman I.S. Novosti meditsiny i farmatsii - News of medicine and pharmacy. 2007; 12: 16–17.
  7. Tentolouris N., Liatis S., Katsilambros N. Ann. NY Acad. Sci. 2006; 1083: 129–152.
  8. Mancia G., Bousquet P., Elghozi J.L., Esler M., Grassi G., Julius S., Reid J., Van Zwieten P.A. J. Hypertens. 2007; 25 (5): 909–920.
  9. Serazin V., Dos Santos E., Morot M., Giudicelli Y. Endocrine. 2004; 25 (2): 97–104.
  10. Cassis L.A. Am. J. Physiol. 1993; 265 (6 Pt. 1): 860–865.
  11. Hendriks-Balk M.C., Peters S.L.M., Michel M.C., Alewijnse A.E. Eur. J. Pharmacol. 2008; 585 (2): 278–291.
  12. Eglen R.M., Bosse R., Reisine T. Assay Drug Dev. Tech. 2007;: 425–451.
  13. Taylor M.R.G. Pharmacogenomics J. 2007; 7 (1): 29–37.
  14. Johnson A.D., Newton-Cheh C., Chasman D.I., Ehret G.B., Johnson T., Rose L., Rice K., Verwoert G.C., Launer L.J., Gudnason V., Larson M.G., Chakravarti A., Psaty B.M., Caulfield M., van Duijn C.M., Ridker P.M., Munroe P.B., Levy D. Hypertension. 2011; 57 (5): 903–910.
  15. Beitelshees A.L., Zineh I., Yarandi H.N., Pauly D.F., Johnson J.A. Pharmacogenomics J. 2006; 6 (3): 174–178.
  16. Nieminen T., Lehtimaki T., Laiho J., Rontu R., Niemela K., Koobi T., Lehtinen R., Viik J., Turjanmaa V., Kahonen M. J. Appl. Physiol. 2006; 100 (2): 507–511.
  17. Pescatello L.S., Blanchard B.E., Tsongalis G.J., Maresh C.M., Griffiths B., Thompson P.D. Vasc. Dis. Prevention. 2009; 6 (1): 56–64.
  18. Peng Y., Xue H., Luo L., Yao W., Li R. Clin. Chem. Lab. Med. 2009; 47 (10): 1227–1231.
  19. Bengtsson K., Melander O., Orho-Melander M., Lindblad U., Ranstam J., Rastam L., Groop L. Circulation. 2001; 104 (2): 187–190.
  20. Mahaesh Kumar K.N., Ramu P., Rajan S., Shewade D.G., Balachander J., Adithan C. J. Cardiovasc. Pharmacol. 2008; 52 (5): 459–466.
  21. Savel'eva E.G. Klinicheskaya i instrumental'naya otsenka effektivnosti betaksolola u bol'nykh gipertonicheskoi bolezn'yu: geneticheskie aspekty individual'noi chuvstvitel'nosti [Clinical and Instrumental Assessment of Efficiency of Betaxolol Application in Patients with Idiopathic Hypertensia: Genetic Aspects of Individual Responsivity]. Moscow, Uch.-nauch. tsentr Meditsinskogo tsentra upravleniya delami Prezidenta RF, 2007. 116 p.
  22. Minushkina L.O. Geneticheskie faktory pri gipertonicheskoi bolezni: svyaz' s osobennostyami techeniya, razvitiem oslozhnenii, effektivnost'yu terapii [Genetic Aspects of Idiopathic Hypertensia: Influence on Progress Characteristics, Effects Development and Therapy Efficiency]. Moscow, 2008. 288 p.
  23. Nedogoda S.V., Barykina I.N., Brel' U.A., Butrina L.V., Chalyabi T.A. Kardiovask. ter. i profilaktika = Cardiovascular therapy and prophylaxis. 2008; 5: 105–115.

Copyright (c) 1970 "Paediatrician" Publishers LLC



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies