PERSPECTIVE ОF USE ОF AGONISTS OF ADENOSINE AND OPIOID RECEPTORS FOR PREVENTION OF REPERFUSION DAMAGES OF HEART. ANALYSIS OF EXPERIMENTAL AND CLINICAL DATA

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Abstract

In Russia inhospital lethality after acute myocardial infarction is 16,5–16,7%. The part of patients perishes even after recanalisation of infarctrelated coronary artery as a result of reperfusion cardiac injury. Experimental data indicate that adenosine receptor agonists and opioids can prevent reperfusion damages of heart that is mimic postconditioning phenomena. Data of clinical observation show that adenosine during intravenous infusion or intracoronary administration during thrombolysis or percutaneous coronary intervention exert infarct reducing effect and eliminate manifestation of «no-reflow» phenomenon. Clinical data indicate that morphine is able to prevent cardiac reperfusion injury in human. Thus, analysis of published data testifies that adenosine and opioid receptor agonists can be prototype for development of drugs for prophylaxis of reperfusion heart injury.

About the authors

L. N. Maslov

Research Institute for Cardiology, Tomsk

Author for correspondence.
Email: Maslov@cardio-tomsk.ru
PhD, professor, Head of the Laboratory of Experimental Cardiology of Research Institute of Cardiology Russian Federation

A. G. Mrochek

Republic Scientific-Practical Center «Cardiology», Minsk

Email: a.mrochek@mail.by
PhD, professor, academician of the National Academy of Sciences of Belarus, Director of the Republic Research Centre “Cardiology” Belarus

I. G. Khaliulin

University of Bristol

Email: I.Khaliulin@bristol.ac.uk
MD, research scientist of the Laboratory of Biochemistry of Bristol University United Kingdom

A. G. Portnichenko

A.A. Bogomoletz Institute of Physiology, Kiev

Email: port@serv.biph.kiev.ua
MD, senior research scientist of the Department of General and Molecular Pathophysiology of A.A. Bogomol'ts Institute of Physiology Ukraine

Eva Chausskaya

The Hebrew University of Jerusalem

Email: evchik@inbox.ru
MD, research scientist at the Department of Developmental Biology and Cancer Research, Faculty of Medicine of the Hebrew University of Jerusalem Israel

A. V. Krylatov

Research Institute for Cardiology, Tomsk, Russian Federation

Email: Maslov@cardio-tomsk.ru

MD, senior research scientist of the Laboratory of Experimental Cardiology of Research Institute of Cardiology. Address: 111, Kievskaya Street, Tomsk, RF, 634012, tel.: +7 (3822) 26-21-74

Russian Federation

N. V. Naryzhnaya

Research Institute for Cardiology, Tomsk, Russian Federation

Email: natalynar@yandex.ru
kandidat meditsinskikh nauk, starshii nauchnyi sotrudnik laboratorii ekspe-rimental’noi kardiologii NII kardiologii
Address: 111, Kievskaya Street, Tomsk, RF, 634012, tel.: +7 (3822) 26-21-74 Russian Federation

A. S. Gorbunov

Research Institute for Cardiology, Tomsk, Russian Federation

Email: barabator@sibmail.com

kandidat meditsinskikh nauk, mladshii nauchnyi sotrudnik laboratorii eksperimental’noi kardiologii NII kardiologii
Address: 111, Kievskaya Street, Tomsk, RF, 634012, tel.: +7 (3822) 26-21-74

Russian Federation

S. Yu. Tsibul'nikov

Research Institute for Cardiology, Tomsk, Russian Federation

Email: seregka2010@hotmail.com
kandidat meditsinskikh nauk, mladshii nauchnyi sotrudnik laboratorii eksperimental’noi kardiologii NII kardiologii
Address: 111, Kievskaya Street, Tomsk, RF, 634012, tel.: +7 (3822) 26-21-74 Russian Federation

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