PATHOPHYSIOLOGICAL ASPECTS OF WOUND HEALING IN NORMAL AND DIABETIC FOOT

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Abstract

The main cause of long-term healing of ulcers in patients with diabetic foot is considered to be direct mechanical damage when walking due to reduced sensitivity to due to neuropathy, hyperglycemia, infection and peripheral artery disease. These factors determine the standard approaches to the treatment of diabetic foot, which include: offloading, glycemic control, debridement of ulcers, antibiotic therapy and revascularization. Recently, however, disturbances in the healing process of the skin in diabetes recognized an additional factor affecting the timing of healing patients with diabetic foot. Improved understanding and correction of cellular, molecular and biochemical abnormalities in chronic wound in combination with standard of care for diabetic foot gives new hope to solve the problem of ulcer healing in diabetes.

 

About the authors

N. V. Maksimova

Sechenov First Moscow State Medical University, Russian Federation

Author for correspondence.
Email: maximova.nadezhda@gmail.com
кандидат медицинских наук, ассистент кафедры эндокринологии лечебного факультета Первого МГМУ им. И.М. Сеченова Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 530-32-16 Россия

A. V. Lyundup

Sechenov First Moscow State Medical University, Russian Federation

Email: lyundup@gmail.com
кандидат медицинских наук, заведующий отделом биомедицинских исследований НИИ молекулярной медицины Первого МГМУ им. И.М. Сеченова Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 609-14-00 Россия

R. O. Lyubimov

Sechenov First Moscow State Medical University, Russian Federation

Email: lubimov@onet.ru
аспирант Первого МГМУ им. И.М. Сеченова Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 530-32-16 Россия

G. A. Mel'nichenko

Sechenov First Moscow State Medical University, Russian Federation

Email: teofrast2000@mail.ru
академик РАН, доктор медицинских наук, профессор кафедры эндокринологии лечебного факультета Первого МГМУ им. И.М. Сеченова Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 609-14-00 Россия

V. N. Nikolenko

Sechenov First Moscow State Medical University, Russian Federation
M.V. Lomonosov Moscow State University, Russian Federation

Email: nikolenko@mma.ru
доктор медицинских наук, профессор кафедры анатомии человека Первого МГМУ им. И.М. Сеченова, заведующий кафедрой нормальной и топографической анатомии факультета фундаментальной медицины МГУ им. М.В. Ломоносова Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 609-14-00 Россия

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