CONFOCAL LASER ENDOMICROSCOPY OF GASTROINTESTINAL TRACT: HISTORY, PROBLEMS AND PERSPECTIVES IN CHILDREN
- Authors: Shavrov A.A.1, Shavrov A.A.2, Kharitonova A.Y.2, Morozov D.A.1, Talaev A.G.1, Gaidarenko A.E.1, Kalashnikova N.A.3
-
Affiliations:
- Scientific Centre of Children Health, Moscow, Russian Federation
- Moscow Research Institute of Emergency Pediatric Surgery and Traumatology, Russian Federation
- Ivanovo State Medical Academy, Russian Federation
- Issue: Vol 69, No 11-12 (2014)
- Pages: 60-66
- Section: PEDIATRICS: CURRENT ISSUES
- Published:
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/370
- DOI: https://doi.org/10.15690/vramn.v69i11-12.1184
- ID: 370
Cite item
Full Text
Abstract
In this review history, principles, technique and clinical applications of confocal laser endomicroscopy are briefly described. This technology allows to expand the diagnostic ability of traditional white light endoscopy and to assess effectiveness of therapeutic procedures in different gastrointestinal diseases. New experimental and clinical data in assessing small bowel barrier dysfunction as a predictor of relapse for inflammatory bowel disease is presented. Problems and perspectives regarding application of optical biopsy for gastrointestinal tract in pediatric practice are discussed.
About the authors
A. A. Shavrov
Scientific Centre of Children Health, Moscow, Russian Federation
Author for correspondence.
Email: shavrovnczd@yandex.ru
врач-эндоскопист эндоскопического отделения Научного центра здоровья детей Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-04-12 Россия
A. A. Shavrov
Moscow Research Institute of Emergency Pediatric Surgery and Traumatology, Russian Federation
Email: shavrovAA@yandex.ru
доктор медицинских наук, ведущий научный сотрудник отделения гнойной хирургии НИИ неотложной детской хирургии и травматологии Адрес: 119180, Москва, ул. Большая Полянка, д. 22, тел.: +7 (495) 959-51-20 Россия
A. Yu. Kharitonova
Moscow Research Institute of Emergency Pediatric Surgery and Traumatology, Russian Federation
Email: anesthesia08@mail.ru
кандидат медицинских наук, старший научный сотрудник отделения гнойной хирургии НИИ неотложной детской хирургии и травматологии Адрес: 119180, Москва, ул. Большая Полянка, д. 22, тел.: +7 (495) 959-51-20 Россия
D. A. Morozov
Scientific Centre of Children Health, Moscow, Russian Federation
Email: morozov@nczd.ru
доктор медицинских наук, профессор, заведующий отделением общей хирургии Научного центра здоровья детей Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-13-17 Россия
A. G. Talaev
Scientific Centre of Children Health, Moscow, Russian Federation
Email: talalaev@mail.ru
доктор медицинских наук, профессор, заведующий патологоанатомической лабора- торией Научного центра здоровья детей Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (495)237-07-72 Россия
A. E. Gaidarenko
Scientific Centre of Children Health, Moscow, Russian Federation
Email: amniot@yandex.ru
врач-эндоскопист эндоскопического отделения Научного центра здоровья детей Адрес: 119991, Москва, Ломоносовский пр-т, д. 2, стр. 1, тел.: +7 (499) 134-04-12 Россия
N. A. Kalashnikova
Ivanovo State Medical Academy, Russian Federation
Email: anesthesia08@mail.ru
кандидат медицинских наук, доцент кафедры анатомии ИвГМА Адрес: 153012, Иваново, Шереметьевский пр-т, д. 8, тел.: +7 (4932) 300-622 Россия
References
- Minsky M. Memoir on inventing the confocal scanning microscopy. Scanning. 1988; 10: 128–138.
- Minsky M. Microscopy apparatus. Pat. US № 3013467 A оn 19.12.1961.
- Egger M.D., Petran M. New reflected-light microscope for viewing unstained brain and ganglion cells. Science. 1967; 157: 305–307.
- Brakenhoff G.J., Blom P., Barends P. Confocal scanning light microscopy with high aperture immersion lenses. J. Microscopy. 1979; 117: 219–232.
- Hamilton D.K., Wilson T. Scanning optical microscopy by objective lens. Scanning J. Physics. 1986; 19: 52–54.
- Cavanagh H.D., Jester J.V., Essepian J., Shields W., Lemp M.A. Confocal microscopy of the living eye. CLAO J. 1990; 16: 65–73.
- Rajadhyaksha M., Grossman M., Esterowits D., Webb R.H., Anderson R.R. In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J. Invest. Dermatol. 1995; 104: 946–952.
- Innoue H., Igari T., Nishikage T., Ami K., Yoshida T., Iwai T. A novel method of virtual histopathology using laser-scanning confocal microscopy in vitro with untreated fresh speciments from the gastrointestinal mucosa. Endoscopy. 2000; 32: 439–443.
- Kiesslich R., Burg J., Vieth M., Gnaendiger J., Enders M., Delaney P. Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo. Gastroenterology. 2004; 3: 706–713.
- Kiesslich R., Gossner L., Goetz M., Dahlmann A., Vieth M., Stolte M., Hoffman A., Neurath M.F. In vivo histology of Barrett’s esophagus and associated neoplasia by confocal laser endomicroscopy. Clin. Gastroent. Hepatol. 2006; 4: 979–987.
- Kwan A.S., Barry C., McAllister I.L., Constable I. Flourescein angiography and adverse drug reactions revisited: the Lions Eye experience. Clin. experiment ophthalmol. 2006; 34: 33–38.
- Lopez-Saez M.P., Ordoqui E., Tornero P., Baeza A., Sainza T., Zubeldia J.M., Baeza M.L. Fluorescein-induced allergic reaction. Ann. Allergy Asthma Immunol. 1998; 81: 428–430.
- Yannuzzi L.A., Rohrer K.T., Tindel L.J., Sobel R.S., Costanza M.A., Shields W., Zang E. Fluorescein angiography complication survey. Ophthalmology. 1986; 93: 611–617.
- Wallace M.B., Meining A., Canto M.I., Fockens P., Miehlke S., Roesch T., Lightdale C.J., Pohl H., Carr-Locke D., Lohr M., Coron E., Filoche B., Giovannini M., Moreau J., Schmidt C., Kiesslich R. The safety of intravenous fluorescein for confocal laser endomicroscopy in the gastrointestinal tract. Alimen. Pharmacol. and Ther. 2010; 31 (5): 548–552.
- Becker V., von Delius S., Bajbouj M., Karagianni A., Schmid R.M., Meining A. Intravenous application of fluorescein for confocal laser scanning microscopy: evaluation of contrast dynamics and image quality with increasing injection to imaging time. Gastrointest. Endosc. 2008; 68: 319–323.
- Wallace M., Bucher A., Becker V., Meining A. Determination of the optimal fluorescein dose of probe based confocal endomicroscopy in colonic imaging. Gastrointest. Endosc. 2009; 69 (5): 375.
- De Palma G.D. Confocal laser endomicroscopy in the in vivo histological diagnosis of the gastrointestinal tract. World J. Gastoenterol. 2009; 15 (46): 5770–5775.
- George M., Meining A. Cresyl violet as a flourophore in confocal laser scanning microscopy for future in vivo histopathology. Endoscopy. 2003; 35: 1033–1038.
- Шавров (мл.) А.А., Александров А.Е., Шавров А.А., Харитонова А.Ю., Волынец Г.В., Талалаев А.Г. Безопасность внутривенного введения флуоресцеина при конфокальной лазерной эндомикроскопии пищеварительного тракта у детей. Педиатрическая фармакология. 2013; 10 (5): 56–58.
- Buchner A.M., Gomez V., Heckman M.G., Shahid M.W., Achem S., Gill K.R., Jamil L.H., Kahaleh M., Lo S.K., Picco M., RiegertJohnson D., Raimondo M., Sciemeca D., Wolfsen H., Woodward T., Wallace M.B. The learning curve of in vivo probe-based confocal laser endomicroscopy for prediction of colorectal neoplasia. Gastrointest. Endosc. 2011; 73 (3): 556–560.
- Wallace M.B., Ussui V.M. Confocal endomicroscopy of colorectal polyps. Gastroenterol. Res. & Practice. 2012; 6.
- Wang P., Ji R. Classification of histological severity of Helicobacter pylori associated gastritis by confocal laser endomicroscopy. World J. Gastoenterol. 2010; 16 (41): 5203–5210.
- Wallace M., Lauwers G.Y., Chen Y., Dekker E., Fockens P., Sharma P., Meining A. Miami classification for probe-based confocal laser endomicroscopy. Endoscopy. 2011; 43 (10): 882–891.
- Kiesslich R., Duckworth C.A., Moussata D., Gloeckner A., Lim L.G., Goetz M.,Pritchard D.M., Galle P.R., Neurath M.F., Watson A. Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut. 2012; 61 (8): 1146–1153.
- Баранов А.А., Климанская Е.В., Римарчук Г.В. Детская гастроэнтерология. М. 2002. 592 с.
- Di Pietro M., Fitzgerald R.C. Screening and risk stratification for Barrett’s esophagus: how to limit the clinical impact of the increasing incidence of esophageal adenocarcinoma. Gastroenterol. Clin. North Am. 2013; 42 (1): 155–173.
- Pohl H., Rosch T., Vieth M., Koch M., Becker V., Anders M., Khalifa A.C., Meining A. Miniprobe confocal laser microscopy for the detection of invisible neoplasia in patients with Barrett’s esophagus. Gut. 2008; 57: 1648–1653.
- Ивашкин В.Т., Баранская Е.К, Кайбышева В.О., Иванова Е.В., Федоров Е.Д. Эозинофильный эзофагит: обзор литературы и описание собственного наблюдения. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2012; 1: 71–81.
- Putnam P.E., Rothenberg M.E. Eosinophilic esophagitis: concepts, controversies, and evidence. Curr. Gastroenterol. Rep. 2009; 11: 220–225.
- Neumann H., Veith M., Atreya R., Mudter J., Neurath M.F. Description of eosinophilic esophagitis using confocal laser endomicroscopy. Endoscopy. 2011; 43: 66.
- Лазебник Л.Б., Щербаков П.Л. Гастроэнтерология. М.: Издание медицинских книг. 2011. 357c.
- Dixon M.F., Genta R.M., Yardley J.H., Correa P. Classification and grading of gastritis. The updated Sydney System. Am. J. Surg. Pathol. 1996; 20: 1161–1181.
- Harris L., Park J., Voltaggio L., Lam-Himlin D. Celiac disease: clinical, endoscopic and histopathologic review. Gastrointest. Endosc. 2012; 76 (3): 625–640.
- Leong R., Humphris J., Swartz D., Egan B. Status of confocal laser endomicroscopy in gastrointestinal disease. Tropical Gastroenterology. 2012; 33 (1): 9–20.
- Cheon J.H., Kim W.H. Recent advances of endoscopy in inflammatory bowel diseases. Gastrointest. Endosc. 2008; 18: 451–466.
- Kiesslich R., Goetz M., Lammersdorf K. Chromoscopy guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology. 2007; 132: 874–882.
- Kiesslich R., Goetz M., Mangues E.M. Identification of epithelial gaps in human small and large intestine by confocal laser endomicroscopy. Gastroenterology. 2007; 133: 1769–1778.
- Meddings J. The significance of the gut barrier disfynction in disease. Gut. 2008; 57 (4): 438–440.
- Watson A.J., Chu S., Sieck L. Gerasimenko O. Epithelial barrier function in vivo is sustained despite gaps in epithelial layer. Gastroenterology. 2005; 129: 902–912.
- Shih D.Q., Targan S.R. Insights into IBD pathogenesis. Curr. Gastroenterol. Rep. 2009; 11: 473–480.
- Rutgeerts P., Feagan B.G., Lichtenstein G.R., Mayer L.F., Wolf D.C., Bao W. Comparison of scheduled and episodic treatment strategies of infliximab in Crohn’s Disease. Gastroenterology. 2004; 126: 402–413.
- Nenci A., Becker C., Wullaert A., Gareus R., van Loo G., Danese S., Huth M. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature. 2007; 446: 557–461.
- Garret W.S., Lord G.M., Punit S., Lugo-Villarino G., Mazmanian S.K., Ito S. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007; 131: 33–45.
- Liu JJ., Wong K., Thiesen A.L., B. Claggett, Mah S.J. Increased epithelial gaps in the small intestines of patients with inflammatory bowel disease: density matters. Gastrointest. Endosc. 2011; 73: 1174–1180.
- Liu J.J., Madsen K.L., Boulanger P., Dieleman L.A., Meddinks J. Mind the gaps: confocal endomicroscopy showed increased density of small bowel epithelial gaps in inflammatory bowel disease. J. Clin. Gastroenterol. 2011; 45: 240–245.
- Crobach M.J., Dekkers O.M., Wilcox M.H., Kuijper E.J. European Society of Clinical Microbiology and Infectious Disease: data review and recommendations for diagnosing Clostridium difficile infection. Clin. Microbiol. Infect. 2009; 15 (12): 1053–1066.
- Neumann H., Vieth M., Grauer M., Grauer M., Wittkopf N. Confocal laser endomicroscopy for in vivo diagnosis of Clostridium difficile associated colitis a pilot study. Gastrointest. Endosc. 2011; 73 (4): 142.
- Glucksberg H., Storb R., Fefer A., Buckner C.D., Neiman P.E. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA matched sibling donors. Transplantation. 1974; 18: 295–304.
- Geeg H.J. How to treat acute GVHD. Blood. 2007; 109: 4119–4126.
- Cox G.J., Matsui S.M., Lo R.S., Hinds M., Bowden R.A., Hackman R.C. et al. Etiology and outcome of diarrhea after marrow transplantation: a prospective study. Gastroenterology. 1994; 107: 1398–1407.
- Shulman H.M., Kleiner D., Lee S.J., Morton T., Pavletic S.Z. et al. Histopathologic diagnosis of chronic graft versus host disease. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft versus Host Disease. II Pathology Working Group Report. Biol. Blood Marrow Transplant. 2006; 12: 31–47.
- Bojarski C., Gunther U., Rieger K., Heller F., Zeitz M. In vivo diagnosis of acute intestinal graft-versus-host disease by confocal endomicroscopy. Endoscopy. 2009; 41: 433–438.
- Wang J., Jiang J., Zhao Y., Kuriki K., Suzuji S., Nagaya T. Genetic polymorphisms of glutathione S-transferase genes and susceptibility to colorectal cancer: a case control study in an Indian population. Cancer Epidemiology. 2011; 35 (1): 66–72.
- De Palma G.D., Staibano S., Siciliano S., Persico M., Masone S., Malone F. In vivo characterisation of superficial colorectal neoplastic lesions with high resolution probe based confocal laser endomicroscopy in combination with video mosaicing: a feasibility study to enhance routine endoscopy. Digestive and Liver Disease. 2010; 42 (11): 791–797.
- Sanduleanu S., Driessen A., Gomez-Garsia E., Hemeeteman W. et al. In vivo diagnosis and classification of colorectal neoplasia by chromoendoscopy guided confocal laser endomicroscopy. Clin. Gastroent. Hepatol. 2010; 8 (4): 371–378.
- Benneth J.J., Green R.H. Malignant masquerade: dilemmas in diagnosing biliary obstruction. Surgical Oncology Clin. North Am. 2009; 18 (2): 207–214.
- Fockens P., Wallace M.B. Probe based confocal laser endomicroscopy. Gastroenterology. 2009; 136 (5): 1509–1513.
- Loeser C.S., Robert M.E., Mennone A., Nathanson M.H., Jamidar P. Confocal endomicroscopic examination of malignant biliary strictures and histologic correlation with lymphatics. J. Clin. Gastroenterol. 2011; 45 (3): 246–252.
- Meining A., Saur D., Bajbouj M., Becker V. In vivo histopathology for detection of gastrointestinal neoplasia with a portable, confocal miniprobe: an examiner blinded analysis. Clin. Gastroent. Hepatol. 2007; 5: 1261–1267.
- Giovannini M., Bories E., Monges G., Pesenti C., Cailol F., Delpero J.R. Results of a phase I–II study on intraductal confocal microscopy (IDCM) in patients with common bile duct (CBD) stenosis. Surg. Endosc. & Other Intervent. Techniq. 2011; 25 (7): 2247–2253.
- Шавров (мл.) А.А., Киргизов И.В., Волынец Г.В., Талала-ев А.Г., Харитонова А.Ю., Шавров А.А. Конфокальная лазерная эндомикроскопия в диагностике осложнений гастроэзофагеальной рефлюксной болезни у детей. Российский педиатрический журнал. 2013; 4: 10–15.
- Шавров А.А. (мл.), Киргизов И.В., Шавров А.А., Талалаев А.Г., Харитонова А.Ю., Волынец Г.В., Джилавян М.Г. Конфокальная лазерная эндомикроскопия в оценке результатов хирургического лечения гастроэзофагеальной рефлюксной болезни у детей. Детская хирургия. 2014; 2: 16–19.
- Венедиктова М.М., Шавров А.А. Конфокальная лазерная эндомикроскопия в диагностике воспалительных заболеваний кишечника у детей. Вопросы диагностики в педиатрии. 2012; 4: 17–21.