TYPE 1 DIABETES MELLITUS, DIABETIC NEPHROPATHY: TRANSPLANTOLOGY POTENTIAL

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Abstract


The review covers the role of transplantology in treatment of patients with type 1 diabetes and the state of its development in the world and in Russia. The results of major multicenter studies, devoted to the influence of simultaneous kidney and pancreas transplantation and kidney transplantation alone on life expectancy and quality of life of diabetic patients are summarized here. Experience in pancreas-kidney transplantation, gained in Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, is described, including surgical technical and postoperative treatment. Also we perform the results of research work, devoted to the influence of pancreas transplantation on different homeostasis parameters, such as: oxidative stress parameters, homocysteine, receptor for advanced glycation endproduct (RAGE), and markers of endocrine function of pancreas transplant.



About the authors

S. V. Got'e

Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow

Author for correspondence.
Email: infotranspl@rambler.ru

Russian Federation доктор медицинских наук, профессор, академик РАМН, директор ФГБУ «Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова» Минздравсоцразвития России Адрес: 123182, Москва, ул. Щукинская, 1 Тел.: (499) 196-18-03, факс (499) 193-87-61

References

  1. Dedov I.I., Shestakova M.V. Diabeticheskaya nefropatiya. M.: Universum Pablishing. 2000: 240.
  2. World Health Organisation Report: World Health Statistics 2011. Available at: http://www.who.int
  3. Bikbov B.T., Tomilina N.A. Nefrologiya i dializ = Nephrology and dialysis. 2007; 1: 18–73.
  4. Shestakova M.V., Shamhalova M.Sh., Yarek-Martynova I.Ya. et al. Saharnyi diabet = Diabetes. 2011; 1: 81–87.
  5. Sountsov Yu.I., Dedov I.I., Shestakova M.V. Screening of diabetes mellitus complications as a method to evaluate the quality of patient care. Ministry of Health and Social Development of the Russian Federation. FSE Research Centre of Endocrinology. 2008.
  6. Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation. OPTN/SRTR 2010 Annual Data Report. 2011. Available at: http://www.optn.transplant.hrsa.gov
  7. Molnar-Varga M., Molnar M.Z., Szeifert L., Kovacs A.Z. Healthrelated quality of life and clinical outcomes in kidney transplant recipients. Am. J. Kidney Dis. 2011; 58 (3): 444–452.
  8. Boerner B.P., Shivaswamy V., Desouza C.V., Larsen J.L. Diabetes and cardiovascular disease following kidney transplantation. Curr. Diabetes Rev. 2011; 7 (4): 221–234.
  9. Gruessner R.W.G., Sutherland D.E. Transplantation of the Pancreas. New York, Spring-Verlang, 2004: 349–380.
  10. Got'e S.V., Arzumanov S.V., Cirul'nikova O.M et al. Vestnik transplantologii i iskusstvennyh organov = Bulletin of transplantation and artificial organs. 2010: 36–37.
  11. Got'e S.V., Cirul'nikova O.M., Popcov V.N. et al. Annaly hirurgicheskoi gepatologii = Annals of surgical hepatology. 2011; 1: 12–14.
  12. Got'e S.V., Arzumanov S.V., Lur'e Yu.E., Cirul'nikova O.M. Immunosupressivnaya terapiya pri transplantacii podjeludochnoi jelezy. Immunosupressiya pri transplantacii solidnyh organov / pod red. S.V. Got'e [Immunosuppressive Therapy of Pancreas Transplantation. Immunosuppression with Solid Organ Transplantation. Edited by S.V. Got'e]. Moscow, Tver, Triada Publishers, 2011. 472 p.
  13. Gruessner D.B., Sutherland D.E. Pancreas transplant outcomes for United States and non-US cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) as of June 2004. Clin. Transplant. 2005; 19: 433.

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