DIABETES MELLITUS AND CHRONIC KIDENY DISEASE: MODERN DIAGNOSTICS AND TREATMENT

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Abstract

Diabetic nephropathy (DN) – is a leading cause of terminal renal failure in the developed countries. Kidney pathology development undergoes several
stages – from preclinical structural changes in the first years of the disease to diffuse or nodular glomerulosclerosis 15-20 years after the diabetes onset. Microalbuminuria is an early marker of DN. Intensive treatment of DN at the stage of microalbuminuria leads to regress and remission of lab parameters of DN in 40 – 50 % of patients after 2 years of treatment. Prognostic factors of DN remission are: tight glycaemia control, arterial hypertension control, especially while treated with renin-angiotensin blockers. Regress of structural changes of kidney tissue In a diabetic patient is possible only after a long-term (>10yrs) normoglycaemia maintenance.

About the authors

М. V. Shestakova

Scientific centre of endocrinology Ministry of Healthcare and Social development of Russia, Moscow

Author for correspondence.
Email: nephro@endocrincentr.ru
доктор медицинских наук, профессор, член-корр. РАМН, директор Института диабета ФГБУ «Эндокринологический научный центр» Минздравсоцразвития России Адрес: 117036, Москва, ул. Дм. Ульянова, 11 Тел./факс: (499) 124-45-00 Россия

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