CLINICAL SIGNIFICANCE OF INSULIN RESISTANCE SYNDROME IN DEVELOPMENT OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH PRIMARY GOUT

Cover Page


Cite item

Full Text

Abstract

Endothelial function has been studied in 175 males with primary gout. It has been established that incidence of endothelial dysfunction in patients with primary gout was associated with the clinical course and was marked most of all in patients who had a chronic gout. The correlations found between the parameters of endothelial dysfunction and impaired carbohydrate metabolism suggest close link and coordination between the above processes which contribute greatly to development and progress of atherosclerosis in such patients.

About the authors

N. N. Kushnarenko

Chita State Medical Academy Ministry of Healthcare and Social development of Russia, Chita, Russia

Author for correspondence.
Email: pochta@medacadem.chita.ru
кандидат медицинских наук, заведующая кафедрой внутренних болезней стома- тологического и педиатрического факультетов Читинской государственной медицинской академии. Россия

A. V. Govorin

Chita State Medical Academy Ministry of Healthcare and Social development of Russia, Chita, Russia

Email: pochta@medacadem.chita.ru
доктор медицинских наук, профессор, заслуженный врач РФ, ректор ГОУ ВПО Читинской государственной медицинской академии, заведующий кафедрой факультетской терапии. Россия

O. A. Shcherbakova

Chita State Medical Academy Ministry of Healthcare and Social development of Russia, Chita, Russia

Email: pochta@medacadem.chita.ru
Россия

S. G. Sotnikova

Chita State Medical Academy Ministry of Healthcare and Social development of Russia, Chita, Russia

Email: pochta@medacadem.chita.ru
Россия

O. V. Ivanitskaya

Chita State Medical Academy Ministry of Healthcare and Social development of Russia, Chita, Russia

Email: pochta@medacadem.chita.ru
Россия

References

  1. Namakanov B.A., Rasulov M.M. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular therapy and prophylaxis. 2005; 4 (6): 98−101.
  2. Trusov V.V., Filimonov M.A., Aksenov K.V. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular therapy and prophylaxis. 2005; 4 (6): 62−66.
  3. Petrischev N.N. Disfunktsiya endoteliya: prichiny, mekhanizmy, farmakologicheskaya korrektsiya [Endothelial Dysfunction: Etiology, Mechanisms, Pharmacological Correction]. St. Petersburg, SPbGMU, 2003. 184 p.
  4. Furchgott R.F, Vanhoutte P.M. Еndothelium-derived relaxing and contracting factors. FASEB J. 1989; 3: 2007−2018.
  5. Rackley C.E. Endothelial UpToDate. 2002; 10. Available at: http://www.uptodate.com
  6. Kanellis J., Kang D.H. Uric acid as a mediator of endothelial dysfunction, inflammation and vascular diseas. Semin. Nephrol. 2005; 25: 39−42.
  7. Lapkina N.A., Baranov A.A., Barskova V.G. et al. Ter. arhiv = Therapeutic archive. 2005; 6: 62−65.
  8. Laakso M., Sarlund H., Mykkanen L. Insulin resistance is associated with lipid and lipoprotein abnormalities in subject with varying degrees of glucose tolerance. Arteriosclerosis. 1990; 10: 223−231.
  9. Wallace К.L., Riedel A.A., Joseph-Ridge N. et al. Increasing prevalence of gout and hyperuricemia over 10 years among older adult in a managed care population. J. Rheumatol. 2004; 31: 1582−1587.
  10. Ivanova O.V., Rogoza A.N., Balahonova T.V. et al. Kardiologiya = Cardiology. 1998; 3: 37−41.
  11. Hollenbeck C.B., Chen N., Chen Y.-D. I., Reaven G.М. Relationship between the plasma insulin response to oral glucose and insulin-stimulated glucose utilization in normal subjects. Diabetes. 1984; 33: 460−463.
  12. Rojtberg G.E. Metabolicheskii sindrom [Metabolic Syndrome]. Moscow, 2007.
  13. Zatejschikova A.A., Zatejschikov D.A. Kardiologiya = Cardiology. 1998; 9: 68−76.
  14. ESH-ESC Guidelines Committee. ESH-ESC guidelines for the management of arterial hypertension. J. Hypertens. 2007; 21: 1011−1053.
  15. Vogel R.A. Coronary risk factors, endothelial function, and atherosclerosis: a review. Clin. Cardiol. 1997; 20: 426−432.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2012 "Paediatrician" Publishers LLC



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies