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Parvoviruses such as parvovirus H-1 (H-1PV) may selectively infect and lysis cancer cells. The parvoviruses also induce an immune system to eliminate the tumor cells through the formation of anti-cancer immunity. One of the possible mechanisms of antitumor activity is associated with the direct induction of apoptosis by parvoviral proteins NS1 and 11 kDa. Parvovirus-based vectors are promising for gene therapy of oncological diseases and genetic disorders in humans. Parvoviruses were successfully used for the experimental treatment on animal models of human glioma, neuroblastomas, lymphomas, pancreatic carcinoma, carcinomas and breast tumors. ParvOryx is the first oncolytic preparation constructed on the base of H-1PV; its phase I/IIa clinical trials in patients with glioblastoma multiforme are in process.

About the authors

V. B. Loktev

State Research Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk Region
Institute of Cytology and Genetics of SB RAS, Novosibirsk

Author for correspondence.
Email: loktev@vector.nsc.ru
доктор биологических наук, профессор, заведующий отделом молекулярной вирусо- логии флавивирусов и вирусных гепатитов ФБУН ГНЦ ВБ «Вектор» Адрес: 630559, Новосибирская область, пос. Кольцово Тел.: (383) 363-47-53, факс: (383) 363-74-09 Russian Federation

T. Yu. Ivan'kina

State Research Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk Region

Email: ivankina@vector.nsc.ru
главный специалист отдела координации НИР и ОКР ФБУН ГНЦ ВБ «Вектор» Адрес: 630559, Новосибирская область, пос. Кольцово Тел.: (383) 336-61-32, факс: (383) 363-74-09 Russian Federation

S. V. Netesov

State Research Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk Region
Novosibirsk National Research State University, Novosibirsk

Email: nauka@nsu.ru
доктор биологических наук, профессор, член-кор. РАН, проректор по научной работе Новосибирского национального исследовательского государственного университета Адрес: 630090, Новосибирск, ул. Пирогова, д. 2 Тел.: (383) 330-22-42, факс: (383) 330-32-55 Russian Federation

P. M. Chumakov

Novosibirsk National Research State University, Novosibirsk
Engelhardt Institute of Molecular Biology of RAS, Moscow
Lerner Research Institute, Cleveland Clinic Foundation, Cleveland

Email: peter@chumakov.com
доктор биологических наук, профессор, заведующий лабораторией Института молеку- лярной биологии им. В.А. Энгельгардта РАН Адрес: 119991, Москва, ул. Вавилова, д. 32 Тел.: (926) 769-01-90, факс: (499) 135-14-05 Russian Federation


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