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РОЛЬ VEGF В РАЗВИТИИ НЕОПЛАСТИЧЕСКОГО АНГИОГЕНЕЗА

https://doi.org/10.15690/vramn.v67i2.119

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Аннотация

Прогрессия солидных опухолей во многом зависит от степени васкуляризации и ангиогенеза малигнизированной ткани. Из целого спектра проангиогенных факторов наиболее серьезное значение имеет фактор роста эндотелия сосудов (VEGF). Подавление функций VEGF приводит к регрессии неопластических сосудов и ограничению роста опухоли. Многообещающие результаты продемонстрировали клинические испытания комплексной антиангиогенной и химиотерапии различных неопластических образований. В настоящее время препарат бевацизумаб вошел в широкую клиническую практику при терапии рака молочной железы, колоректального рака и глиом III–IV степени злокачественности. К сожалению, в большинстве случаев антиангиогенная терапия не приводит к полному выздоровлению, а лишь замедляет развитие опухоли. Механизмы резистентности включают потенцирование альтернативных проангиогенных сигнальных путей и активацию инвазивной популяции опухолевых клеток.

Об авторах

В. П. Чехонин
ФГУ «Государственный научный центр социальной и судебной психиатрии им. В.П. Сербского» Минздравсоцразвития России, Москва ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздравсоцразвития России, Москва
Россия
доктор медицинских наук, профессор, академик РАМН, заведующий Отделом фундаментальной и прикладной нейробиологии ФГУССП, заведующий кафедрой медицинских нанобиотехно- логий РГМУ Адрес: 119034, Москва, пер. Кропоткинский, д. 23 Тел.: (495) 695-02-62, факс: (495) 636-50-55


С. А. Шеин
ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздравсоцразвития России, Москва
Россия
аспирант кафедры медицинских нанобиотехнологий Адрес: 119634, Москва, ул. Лукинская, д. 11, кв. 191 Тел.: (916) 108-35-09


А. А. Корчагина
ГБОУ ВПО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздравсоцразвития России, Москва
Россия
аспирант кафедры медицинских нанобиотехнологий Адрес: 121601, Москва, Филевский бульвар, д. 11, кв. 84 Тел.: (910) 433-17-76


О. И. Гурина
ФГУ «Государственный научный центр социальной и судебной психиатрии им. В.П. Сербского» Минздравсоцразвития России, Москва
Россия
доктор медицинских наук, руководитель лаборатории нейрохимии ФГУССП Адрес: 117587, Москва, Варшавское шоссе, д. 114/1, кв. 364 Тел.: (495) 695-02-62


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Для цитирования:


Чехонин В.П., Шеин С.А., Корчагина А.А., Гурина О.И. РОЛЬ VEGF В РАЗВИТИИ НЕОПЛАСТИЧЕСКОГО АНГИОГЕНЕЗА. Вестник Российской академии медицинских наук. 2012;67(2):23-34. https://doi.org/10.15690/vramn.v67i2.119

For citation:


Chekhonin V.P., Shein S.A., Korchagina A.A., Gurina O.I. VEGF IN NEOPLASTIC ANGIOGENESIS. Annals of the Russian academy of medical sciences. 2012;67(2):23-34. (In Russ.) https://doi.org/10.15690/vramn.v67i2.119

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