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An overview of the present status and prospects of gnotobiology along with a role of normal microflora studied using laboratory animals with controlled microflora (gnotobiotes) is presented. The principal elements of gnotobiotechnology as well as possibilities of its using in both experimental and clinical investigations are analyzed. A multifaceted role of normal microflora in the host physiology and pathology prejudge the increasing importance of gnotiological models in various fields of biology and medicine, such as the development of new generations probiotics. An assessment and characteristics of selected microbial strains, host-microbe interactions etc. An organization of further complex gnotobiotic research is of prospective value.


About the authors

G. I. Podoprigora

The Russian National Research Medical University named after N.I. Pirogov (RNRMU), Moscow
Research Institute of Cytochemistry and Molecular Pharmacology, Moscow

Author for correspondence.
доктор медицинских наук, профессор, директор НИИ цитохимии и молеку- лярной фармакологии Адрес: 115404, Москва, ул. 6-я Радиальная, д. 24, стр. 14 Тел./факс: (495) 327-49-87 Russian Federation

L. I. Kafarskaya

The Russian National Research Medical University named after N.I. Pirogov (RNRMU), Moscow

доктор медицинских наук, профессор, заведующая кафедрой микробиологии и вирусологии РНИМУ им. Н.А. Пирогова Адрес: 117869, Москва, ул. Островитянова, д. 1 Тел.: (495) 434-17-66 Russian Federation

N. A. Bainov

The Russian National Research Medical University named after N.I. Pirogov (RNRMU), Moscow

кандидат медицинских наук, доцент кафедры микробиологии и вирусологии РНИМУ им. Н.А. Пирогова Адрес: 117869, Москва, ул. Островитянова, д. 1 Тел.: (495) 434-17-66 Russian Federation


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