POLYMORPHISM OF GENES OF THE SYSTEM OF BIOTRANSFORMATION OF XENOBIOTICS IN PATIENTS WITH OCCUPATIONAL ALLERGIC DERMATOSES

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Abstract


Evaluation of genes polymorphic system of xenobiotics biotransformation in patients with оccupational allergodermatoses showed significantly higher percentage of incidence of polymorphic variants of genes CYP 1A1 *2C and EPHX1 AND-415G compared with population control. A combination of 3 or more adverse hetero - and homozygous gene alleles CYP 1A1, CYP3A4, ЕРНХ1 and deletions of genes GSTM1 and GSTT1, is characterized by earlier (with the experience of work in harmful conditions up to 5 years) development, severe and unfavorable prognosis of оccupational pathology of the skin.

 


About the authors

N. F. Izmerov

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Author for correspondence.
Email: izmerov@niimt.ru

Russian Federation доктор медицинских наук, профессор, академик РАМН, заслуженный деятель науки РФ, научный руководитель ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, пр-т Буденного, д. 31 Тел.: (495) 365-02-09, факс: (495) 366-05-83

L. P. Kuz'mina

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Email: lpkuzmina@mail.ru

Russian Federation доктор биологических наук, профессор, заведующая клиническим отделом и лабора- торией медико-биологических исследований Клиники ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, ул. 9-я Соколиной Горы, д. 12 Тел.: (495) 365-14-90

M. M. Kolyaskina

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Email: biochimiamt@mail.ru

Russian Federation кандидат медицинских наук, старший научный сотрудник лаборатории медико- биологических исследований Клиники ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, ул. 9-я Соколиной Горы, д. 12 Тел.: (495) 365-41-59

L. M. Bezrukavnikova

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Email: biochimiamt@mail.ru

Russian Federation кандидат медицинских наук, ведущий научный сотрудник лаборатории медико-биологических исследований Клиники ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, ул. 9-я Соколиной Горы, д. 12 Тел.: (495) 365-41-59

N. A. Lazarashvili

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Email: biochimiamt@mail.ru

Russian Federation кандидат медицинских наук, старший научный сотрудник лаборатории медико- биологических исследований Клиники ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, ул. 9-я Соколиной Горы, д. 12 Тел.: (495) 365-41-59

Ya. A. Petinati

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Email: biochimiamt@mail.ru

Russian Federation кандидат медицинских наук, врач отделения дерматологии Клиники ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, ул. 9-я Соколиной Горы, д. 12 Тел.: (495) 366-80-22

References

  1. Kuz'mina L.P., Bezrukavnikova L.M. et al. Molekulyarnye mekhanizmy i individual'nye osobennosti metabolizma, opredelyayushchie vozniknovenie, klinicheskoe techenie i iskhod professional'nykh i proizvodstvenno-obuslovlennykh zabolevanii. Aktual'nye problemy «Meditsiny truda». Sb. trudov inst. Pod red. akad. RAMN N.F. Izmerova [Molecular mechanisms of metabolism and individual characteristics that determine the occurrence, clinical course and outcome of occupational and production-related diseases. Actual problems of "Medicine of labor". Collection of works. Edited by N.F. Izmerov]. Moscow, 2006. p. 465–478.
  2. Spitsyn V.A. Ekologicheskaya genetika cheloveka [Ecological genetics of man]. Moscow, Nauka, 2008. 503 p.
  3. Izmerova N.I., Ivanova L.A. Klinicheskie aspekty i laboratornaya diagnostika rannikh proyavlenii professional'nykh dermatozov i ikh profilaktika. V sb.: Problemy donozologicheskoi diagnostiki [Clinical aspects and laboratory diagnosis of early manifestations of occupational dermatoses and their prevention. In: Issues of preclinical diagnosis]. Leningrad, 1989. p. 280–281.
  4. Gonzalez D.H., Bonnard G., Grienenberger J.-M. A gene involved in the biogenesis of c-type cytochromes is co-transcribed with a ribosomal protein gene in wheat mitochondria. Curr. Genet. 1993; 21: 248–255.
  5. Sipes I.G., Gandolfi A.J. Biotransformation of toxicants. Casarett and Doull's toxicology. N.-Y.: Macmillan Publishing Company. 1986. 99–173.
  6. Kukes V.G., Grachev S.V. et al. Metabolizm lekarstvennykh sredstv. Nauchnye osnovy personalizirovannoi meditsiny: ruk-vo dlya vrachei [Metabolism of drugs. Scientific basis of personalized medicine: Manual for physicians]. Moscow, GEOTAR-Media, 2008. 304 p.
  7. Kuz'mina L.P. Entsiklopediya po meditsine truda. Pod red. N.F. Izmerova [Encyclopaedia of occupational medicine. Edited by N.F. Izmerov]. Moscow, 2006.
  8. Westphal G.A., Reich K., Schulz T.G. et al. N-acetyltransferase 1 and 2 polymorphisms in para-substituted arylamine-induced contact allergy. Br. J. Dermatol. 2000; 142: 1121–1127.

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