POLYMORPHISM OF GENES OF THE SYSTEM OF BIOTRANSFORMATION OF XENOBIOTICS IN PATIENTS WITH OCCUPATIONAL ALLERGIC DERMATOSES

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Abstract

Evaluation of genes polymorphic system of xenobiotics biotransformation in patients with оccupational allergodermatoses showed significantly higher percentage of incidence of polymorphic variants of genes CYP 1A1 *2C and EPHX1 AND-415G compared with population control. A combination of 3 or more adverse hetero - and homozygous gene alleles CYP 1A1, CYP3A4, ЕРНХ1 and deletions of genes GSTM1 and GSTT1, is characterized by earlier (with the experience of work in harmful conditions up to 5 years) development, severe and unfavorable prognosis of оccupational pathology of the skin.

 

About the authors

N. F. Izmerov

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Author for correspondence.
Email: izmerov@niimt.ru
доктор медицинских наук, профессор, академик РАМН, заслуженный деятель науки РФ, научный руководитель ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, пр-т Буденного, д. 31 Тел.: (495) 365-02-09, факс: (495) 366-05-83 Россия

L. P. Kuz'mina

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Email: lpkuzmina@mail.ru
доктор биологических наук, профессор, заведующая клиническим отделом и лабора- торией медико-биологических исследований Клиники ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, ул. 9-я Соколиной Горы, д. 12 Тел.: (495) 365-14-90 Россия

M. M. Kolyaskina

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Email: biochimiamt@mail.ru
кандидат медицинских наук, старший научный сотрудник лаборатории медико- биологических исследований Клиники ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, ул. 9-я Соколиной Горы, д. 12 Тел.: (495) 365-41-59 Россия

L. M. Bezrukavnikova

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Email: biochimiamt@mail.ru
кандидат медицинских наук, ведущий научный сотрудник лаборатории медико-биологических исследований Клиники ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, ул. 9-я Соколиной Горы, д. 12 Тел.: (495) 365-41-59 Россия

N. A. Lazarashvili

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Email: biochimiamt@mail.ru
кандидат медицинских наук, старший научный сотрудник лаборатории медико- биологических исследований Клиники ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, ул. 9-я Соколиной Горы, д. 12 Тел.: (495) 365-41-59 Россия

Ya. A. Petinati

Federal State Budgetary Research Institute of Occupational Health under the Russian Academy of Medical Sciences, Moscow, Russian Federation

Email: biochimiamt@mail.ru
кандидат медицинских наук, врач отделения дерматологии Клиники ФГБУ «НИИ МТ» РАМН Адрес: 105275, Москва, ул. 9-я Соколиной Горы, д. 12 Тел.: (495) 366-80-22 Россия

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