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Вестник Российской академии медицинских наук

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ПАТОЛОГИЯ ЭМБРИОНАЛЬНОГО МОРФОГЕНЕЗА ГОЛОВНОГО МОЗГА ЧЕЛОВЕКА

https://doi.org/10.15690/vramn.v67i8.348

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Аннотация

Исследованы механизмы развития ранней эмбриональной патологии нервной системы у человека и экспериментальных животных. Установлены биомеханические принципы кодирования позиционной информации нейроэпителиальными клетками. Экспериментальное обратимое изменение тангенциальных межклеточных взаимодействий в нейроэпителии животных приводило к прогнозируемым аномалиям развития нервной системы. Изменение проницаемости механозависимых ионных каналов является основным способом считывания позиционной информации и детерминации клеточной дифференцировки. Было проведено сравнение экспериментальных аномалий мозга у животных с уникальными аутопсиями патологического развития мозга человека начиная от нейруляции и заканчивая 6-м мес внутриутробного развития. Полученные результаты позволили установить, что при задержке движения постнейропорной волны замыкания нервной трубки формируются аномалии переднего мозга и этмоидной части лица. Обнаружено, что при остановке движения постнейропорной волны нейруляции формируются аномалии промежуточного и среднего мозга, а при нарушении каудальной волны — аномалии заднего и спинного мозга. Показано, что аномалии развития, диагностируемые на поздних сроках онтогенеза и после рождения, являются последствиями компенсаторных реакций нейроэпителия на изменение ранних позиционных сигналов в период формирования нервной трубки.

 

Об авторе

С. В. Савельев
ФГБУ «Научно-исследовательский институт морфологии человека» РАМН, Москва
Россия
доктор биологических наук, профессор, руководитель лаборатории развития нервной системы НИИ морфологии человека РАМН Адрес: 117418, Москва, ул. Цюрупы, д. 3 Тел.: (499) 120-00-50


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Для цитирования:


Савельев С.В. ПАТОЛОГИЯ ЭМБРИОНАЛЬНОГО МОРФОГЕНЕЗА ГОЛОВНОГО МОЗГА ЧЕЛОВЕКА. Вестник Российской академии медицинских наук. 2012;67(8):40-46. https://doi.org/10.15690/vramn.v67i8.348

For citation:


Savel'ev S.V. THE EARLY EMBRYONAL ANOMALIES OF HUMAN BRAIN. Annals of the Russian academy of medical sciences. 2012;67(8):40-46. (In Russ.) https://doi.org/10.15690/vramn.v67i8.348

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