IMPACT OF SUBCLINICAL PRIMARY HYPERPARATHYROIDISM ON CARDIOVASCULAR MANIFESTATIONS OF ESSENTIAL ARTERIAL HYPERTENSION

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Abstract


At 95 patients with essential arterial hypertension features of structural and functional remodeling of left ventricular and humeral artery depending on a level parathyroid hormone in blood are studied. It is shown that while increasing of plasma parathyroid hormone level frequency and expressiveness of left ventricular and humeral artery remodeling increases whereas diastolic function and endothelium-dependent vasodilatation considerably decrease. Subclinical primary hyperparathyroidism in patients with essential arterial hypertension is detected in 22,1% of cases.

 


About the authors

B. G. Iskenderov

Penza Institute of Postgraduate Medical Training, Russian Federation

Author for correspondence.
Email: iskenderovbg@mail.ru

Russian Federation доктор медицинских наук, профессор кафедры терапии, кардиологии и функцио- нальной диагностики ГБОУ ДПО «Пензенский институт усовершенствования врачей» МЗ РФ Адрес: 440060, Пенза, ул. Стасова, д. 8А Тел.: (8412) 43-57-93

O. N. Sisina

Penza Institute of Postgraduate Medical Training, Russian Federation

Email: giuv@sura.ru

Russian Federation кандидат медицинских наук, доцент, заведующая кафедрой нефрологии ГБОУ ДПО «Пензенский институт усовершенствования врачей» МЗ РФ Адрес: 440060, Пенза, ул. Стасова, д. 8А Тел.: (8412) 43-57-93

References

  1. Hagström E., Hellman P., Larsson T.E., Ingelsson E., Berglund L., Sundström J., Melhus H., Held C., Lind L., Michaëlsson K., Arnlöv J. Plasma parathyroid hormone and the risk of cardiovascular mortality in the community. Circulation. 2009; 119 (21): 2765–2771.
  2. Andersson P., Rydberg E., Willenheimer R. Primary hyperparathyroidism and heart disease: a review. Eur. Heart J. 2004; 25: 1776–1787.
  3. Silverberg S.J., Lewiecki E.M., Mosekilde L., Peacock M., Rubin M.R. Presentation of asymptomatic primary hyperparathyroidism: Proceedings of the Third International Workshop. J. Clin. Endocrinol. Metab. 2009; 94 (2): 351–365.
  4. Starkova N.T. Klinicheskaya endokrinologiya. Ruk-vo. 3-e izd., pererab. i dop [Clinical Endocrinology. Guideline. 3rd ed., rev. and enlarg.]. St. Petersburg, Piter, 2002. 576 p.
  5. Kamycheva E., Sundsfjord J., Jorde R. Serum parathyroid hormone levels predict coronary heart disease: the Tromsǿ Study. Eur. J. Cardiovasc. Prev. Rehabil. 2004; 11 (1): 69–74.
  6. Sugimoto T., Tanigawa T., Onishi K., Fujimoto N., Matsuda A., Nakamori S., Matsuoka K., Nakamura T., Koji T., Ito M. Serum intact parathyroid hormone levels predict hospitalization for heart failure. Heart. 2009; 95: 395–398.
  7. Voronenko I.V., Mokrysheva N.G., Rozhinskaya L.Ya., Syrkin A.L. The cardiovascular system in symptomatic and malosimptomno primary hyperparathyroidism. Problemy endokrinologii = Problems of Endocrinology. 2009; 3: 17–22.
  8. Rubin M.R., Maurer M.S., McMahon D.J., Bilezikian J.P., Silverberg S.J. Arterial stiffness in mild primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 2010; 90 (6): 3326–3330.
  9. Walker M.D., Fleischer J.B., Di Tullio M.R., Homma S., Rundek T., Stein E.M., Zhang C., Taggart T. Cardiac structure and diastolic function in mild primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 2010; 95 (5): 2172–2179.
  10. Lumachi F., Ermani1 M., Luisetto G., Nardi A., Basso S.M., Camozzi V., Favia G. Relationship between serum parathyroid hormone, serum calcium and arterial blood pressure in patients with primary hyperparathyroidism: results of a multivariate analysis. Eur. J Endocrinol. 2002; 146: 643–647.
  11. Chiu K.C., Chuang L.M., Lee N.P., Ryu J.M., McGullam J.L., Tsai G.P., Saad M.F. Insulin sensitivity is inversely correlated with plasma intact parathyroid hormone level. Metabolism. 2000; 49: 1501–1505.
  12. Diagnosis and treatment of hypertension. Recommendations of Russian Medical Society of hypertension and the All-Russian Scientific Society of Cardiology (third revision). Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular therapy and prevention. 2008; 6 (2): 3–32.
  13. Celermajer D.S., Sorensen K.E., Gooch V.M., Spiegelhalter D.J. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992; 340: 1111–1115.
  14. Saleh F.N., Schirmer H., Sundsfjord J., Jorde R. Parathyroid hormone and left ventricular hypertrophy. Eur. Heart J. 2003; 24: 2054–2060.
  15. Bollerslev J., RosenT., Mollerup Ch. L., Nordenström J., Baranowski M., Franco C., Pernow Y., Isaksen G.A., Godang K., Ueland Th., Jansson S. Effect of surgery on cardiovascular risk factors in mild primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 2009; 94 (7): 2255–2261.

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