CYTOLOGIC FEATURES ОF BRONCHOALVEOLAR LAVAGE IN EVALUATION OF COURSE OF EXOGENOUS ALLERGIC ALVEOLITIS

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Abstract

Application of complex of modern cytologic methods of research bronchoalveolar lavage allowed to allocate most characteristics of development of lymphocytic and macrophagic reaction of bronchial tree in different course of exogenous allergic alveolitis. The most indicative in assessment of origin of exogenous allergic alveolitis development is the characteristics of macrophagic population. In acute course of exogenous allergic alveolitis the considerable number of young activated and non-activated macrophages, increased number of mature phagocytes is observed. Even more significant increase of phagocytic macrophages is observed at dissemination which is primarily is connected with participation of these cells in lymphocytic apoptosis which takes place in high percentage of lymphocytes (up to 49%). Increased number of mature phagocytes is observed at chronic course of exogenous allergic alveolitis that is an important diagnostic pattern of this option of development of exogenous allergic alveolitis in association with the lowest T-helpers/T-supressors index.

 

About the authors

L. N. Lepekha

Central Tuberculosis Research Institute RAMS, Moscow, Russian Federation

Author for correspondence.
Email: lep3@yandex.ru
доктор биологических наук, профессор, заведующая лабораторией патоморфологии ФГБУ ЦНИИТ РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Tел.: (499) 785-91-79 Россия

E. A. Aleksandrova

Central Tuberculosis Research Institute RAMS, Moscow, Russian Federation

Email: lep3@yandex.ru
кандидат биологических наук, старший научный сотрудник лаборатории патоморфологии ФГБУ ЦНИИТ РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 785-91-79 Россия

G. V. Evgushchenko

Central Tuberculosis Research Institute RAMS, Moscow, Russian Federation

Email: lep3@yandex.ru
кандидат медицинских наук, заведующая клинико-диагностической лабораторией ФГБУ ЦНИИТ РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 785-91-94 Россия

N. N. Makar'yants

Central Tuberculosis Research Institute RAMS, Moscow, Russian Federation

Email: lep3@yandex.ru
кандидат медицинских наук, научный сотрудник отдела гранулематозных болезней ФГБУ ЦНИИТ РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 785-91-56 Россия

O. V. Lovacheva

Central Tuberculosis Research Institute RAMS, Moscow, Russian Federation

Email: lep3@yandex.ru
доктор медицинских наук, профессор, заведующая отделением эндоскопии ФГБУ ЦНИИТ РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 785-91-76 Россия

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