FEATURES ОF METABOLIC ACTIVITY ОF VASCULAR ENDOTHELIUM IN PATIENTS WITH PULMONARY TUBERCULOSIS

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Abstract

81 patients with active pulmonary tuberculosis were investigated. The morpho-functional status of vascular endothelium was evaluated by plasma levels of stable metabolites of nitric oxide, endothelin-1 and von Willebrand factor antigen. Typical increase of endothelin-1 in positive correlation with systemic inflammatory response syndrome (SIRS) expression was established. Nitric oxide level decreased in patients with chronic and severe course of disease. Decrease of nitric oxide level was not associated with SIRS but was consequence of specific intoxication. von Willebrand factor antigen decreased in patients with recent and limited spread of tissue damage but increased progressively with intensity of SIRS. This complex of changes (contrast shifts of nitric oxide and endothelin-1 and von Willebrand factor antigen increase) manifested in endothelium metabolic dysfunction syndrome and developed pre-conditions for microcirculation disturbances.

About the authors

G. O. Kaminskaya

Central TB Research Institute of RAMS, Moscow

Author for correspondence.
Email: rizalla@mail.ru
доктор медицинских наук, профессор, главный научный сотрудник отдела патана- томии и биохимии ФГБУ «Центральный НИИ туберкулеза» РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 748-30-23 Россия

R. Yu. Abdaullaev

Central TB Research Institute of RAMS, Moscow

Email: rizalla@mail.ru
профессор, доктор медицинских наук, заведующий лабораторией биохимии ФГБУ «Центральный НИИ туберкулеза РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 748-30-23 Россия

O. G. Komissarova

Central TB Research Institute of RAMS, Moscow

Email: okriz@rambler.ru
доктор медицинских наук, ведущий научный сотрудник отдела фтизиатрии ФГБУ «Центральный НИИ туберкулеза» РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499)785-90-71 Россия

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