Email this article 
FEATURES ОF METABOLIC ACTIVITY ОF VASCULAR ENDOTHELIUM IN PATIENTS WITH PULMONARY TUBERCULOSIS
- Authors: Kaminskaya G.O.1, Abdaullaev R.Y.1, Komissarova O.G.1
-
Affiliations:
- Central TB Research Institute of RAMS, Moscow
- Issue: Vol 67, No 11 (2012)
- Pages: 29-33
- Section: PHTHISIOLOGY: CURRENT ISSUES
- Published: 10.11.2012
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/243
- DOI: https://doi.org/10.15690/vramn.v67i11.468
- ID: 243
Cite item
Full Text
Abstract
81 patients with active pulmonary tuberculosis were investigated. The morpho-functional status of vascular endothelium was evaluated by plasma levels of stable metabolites of nitric oxide, endothelin-1 and von Willebrand factor antigen. Typical increase of endothelin-1 in positive correlation with systemic inflammatory response syndrome (SIRS) expression was established. Nitric oxide level decreased in patients with chronic and severe course of disease. Decrease of nitric oxide level was not associated with SIRS but was consequence of specific intoxication. von Willebrand factor antigen decreased in patients with recent and limited spread of tissue damage but increased progressively with intensity of SIRS. This complex of changes (contrast shifts of nitric oxide and endothelin-1 and von Willebrand factor antigen increase) manifested in endothelium metabolic dysfunction syndrome and developed pre-conditions for microcirculation disturbances.
Keywords
About the authors
G. O. Kaminskaya
Central TB Research Institute of RAMS, Moscow
Author for correspondence.
Email: rizalla@mail.ru
доктор медицинских наук, профессор, главный научный сотрудник отдела патана- томии и биохимии ФГБУ «Центральный НИИ туберкулеза» РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 748-30-23 Россия
R. Yu. Abdaullaev
Central TB Research Institute of RAMS, Moscow
Email: rizalla@mail.ru
профессор, доктор медицинских наук, заведующий лабораторией биохимии ФГБУ «Центральный НИИ туберкулеза РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 748-30-23 Россия
O. G. Komissarova
Central TB Research Institute of RAMS, Moscow
Email: okriz@rambler.ru
доктор медицинских наук, ведущий научный сотрудник отдела фтизиатрии ФГБУ «Центральный НИИ туберкулеза» РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499)785-90-71 Россия
References
- Pushkareva T.A., Koryakina L.B., Runovich A.A, Kuril'skaya T.E., Pivovarov Yu.I. Criteria for evaluation of endothelial dysfunction and its correction. Klin. lab. diagn. = Clinical and laboratory diagnostics. 2008; 5: 3–7.
- Titov V.N. Biochemical markers of endothelium and its role in the unity of the different pools of the intercellular medium and pool intravascular fluid. Klin. lab. diagn. = Clinical and laboratory diagnostics. 2007; 4: 6–15.
- Kaminskaya G.O., Martynova E.V., Serebryanaya B.A., Abdullaev R.Yu., Komisarova O.G. Participate in the formation of the hemostatic system systemic inflammatory response syndrome in patients with pulmonary tuberculosis. Probl. tub. i bol. legkikh = Problems of tuberculosis and lung diseases. 2011; 2: 52–58.
- Surkova L.K., Dyus'mikeeva M.I. Acute progressing pulmonary tuberculosis: morphological and bacteriological characteristics. Probl. tub. = Problems of tuberculosis. 2003; 3: 33–35.
- Erokhin V.V., Lepekha L.N., Zhilin Yu.N., Karpina N.L. Morphological features of acute lung injury in patients with caseous pneumonia. Probl. tub. i bol. legkikh = Problems of tuberculosis and lung diseases. 2006; 10: 43–47.
- Ding A.H., Nathan C.F., Stuehr D.J. Release of nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J. Immunol. 1988; 141: 2407–2408.
- Abdullaev R.Yu., Kaminskaya G.O., Komissarova O.G., Glotova B.V. Serum levels of nitric oxide in the assessment of systemic inflammation in patients with drug-resistant pulmonary tuberculosis. Probl. tub. i bol. legkikh = Problems of tuberculosis and lung diseases. 2009; 5: 40–43.
- Botting R.M., Vane J.R. Endothelins: potent realisers of prostacyclin and EDRF. Pol. J. Pharmacol. 1990; 42: 203–218.
- Ochoa C.D., Wu S., Stevens T. New developments in lung endothelial heterogenity von Willebrand factor, P-selectin and the Weibel-Palade body. Semin. Thromb. Hemostat. 2012; 36 (3): 301–308.
- Paulus P., Jennewien S., Zaharowski K. Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis? Biomarkers. 2011; 16 (1): 11–21.
- Starke R.D., Ferraro F., Paschalaki K., Dryden N.H., McKinnon Th.A.G. Sutton R.E., Payne E.M., Haskard D.O., Hughes A.D., Cutler D.F., Laffan M.A., Randi1 A.M. Endothelial von Willebrand factor regulates angiogenesis. Blood. 2011; 117 (3): 1071–1080.
Supplementary files
