CHEMOTHERAPY OF TUBERCULOSIS: PROBLEMS AND PERSPECTIVES

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Abstract


Challenges of tuberculosis chemotherapy under conditions of high drug resistant (DR) tuberculosis burden are discussed. Ultimate results of treatment by standard regimens of 1658 patients with new tuberculosis cases and relapses were analyzed. Favorable ultimate results were observed among both patients with new tuberculosis cases and relapses having drugs sensitivity. Efficacy of tuberculosis treatment by standard regimens of chemotherapy is decreasing as a result of DR amplification. Risk factors of unfavorable ultimate result among pulmonary tuberculosis patients are primary resistance to isoniazid (OR =2,1) and multiple drug resistance of M. tuberculosis (OR =8,0). Earlier onset of treatment and correct individual therapy with second line drugs as a result of rapid methods of DR tuberculosis diagnostics are those approaches which provide the best therapeutic effect among multiple drug resistant tuberculosis patients both in culture conversion (97,7%) and cavity closure rate (82,7%).

 


I. A. Vasil’eva

Central Tuberculosis Research Institute of RAMS, Moscow, the Russian Federation

Author for correspondence.
Email: vasil39@list.ru

Russian Federation доктор медицинских наук, профессор, руководитель отдела фтизиатрии ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел./факс: (499) 748-30-26

A. G. Samoilova

Central Tuberculosis Research Institute of RAMS, Moscow, the Russian Federation

Email: a.samoilova.ctri@mail.ru

Russian Federation кандидат медицинских наук, старший научный сотрудник отдела фтизиатрии ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 785-90-52

A. E. Ergeshov

Central Tuberculosis Research Institute of RAMS, Moscow, the Russian Federation

Email: cniit@cniitramn.ru

Russian Federation доктор медицинских наук, профессор, заместитель директора по научной и лечебной работе ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 785-90-60

T. R. Bagdasaryan

Central Tuberculosis Research Institute of RAMS, Moscow, the Russian Federation

Email: norair04@mail.ru

Russian Federation кандидат медицинских наук, заведующая терапевтическим отделением ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 785-90-52

L. N. Chernousova

Central Tuberculosis Research Institute of RAMS, Moscow, the Russian Federation

Email: lchernousova@mail.ru

Russian Federation доктор биологических наук, профессор, руководитель отдела микробиологии ФГБУ «Центральный научно-исследовательский институт туберкулеза» РАМН Адрес: 107564, Москва, Яузская аллея, д. 2 Тел.: (499) 748-30-15

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