PROTEOMICS AS A FUNDAMENTAL TOOL FOR SUBCLINICAL SCREENING, TESTS VERIFICATION AND ASSESSMENT OF APPLIED THERAPY

Cover Page
  • Authors: Suchkov S.V.1, Kostushev D.S.2, Krynskii S.A.3, Gnatenko D.A.2, Pal'tsev M.A.4
  • Affiliations:
    1. I.M. Sechenov First Moscow State Medical University, Russian Federation A.I. Evdokimov Moscow State Medical Dental University, Russian Federation
    2. A.I. Evdokimov Moscow State Medical Stomatological University Moscow, Russian Federation
    3. I.M. Sechenov First Moscow State Medical University, Russian Federation
    4. National Research Centre «Kurchatov Institute», Moscow, Russian Federation
  • Issue: Vol 68, No 1 (2013)
  • Pages: 65-71
  • Section: SHORT MESSAGES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/227
  • DOI: https://doi.org/10.15690/vramn.v68i1.540
  • Cite item

Abstract


Proteomics is a science which studies proteins of the body, interactions of proteins and their biological functions. Today, it is an essential partner in establishing preclinical diagnosis protocols. In conjunction with other sciences such as genomics and bioinformatics it will be possible to diagnose diseases on the earliest stages before its clinical onset or to gain the dynamics of pathological processes in the body and response to drug therapy. This article discusses general aspects of proteomics as well as special ones on the basis of models of cardiac diseases and cancer.

 


S. V. Suchkov

I.M. Sechenov First Moscow State Medical University, Russian Federation
A.I. Evdokimov Moscow State Medical Dental University, Russian Federation

Author for correspondence.
Email: ssuchkov57@gmail.com

Russian Federation

PhD, Professor of Department of A.I. Evdokimov Clinical Immunology, Professor of Department of Pathology I.M. Sechenov First Moscow State Medical University
Address: 101000, Moscow, Miasnitskaya St., 20; tel.: (495) 771-32-32; fax: (495) 708-31-56

D. S. Kostushev

A.I. Evdokimov Moscow State Medical Stomatological University Moscow, Russian Federation

Email: dkostushev@gmail.com

Russian Federation

Intern Researcher of Department of Pathology I.M. Sechenov First Moscow State Medical University
Address: 119991, Moscow, Trubetskaya St., 8/2; tel.: (425) 037-08-54

S. A. Krynskii

I.M. Sechenov First Moscow State Medical University, Russian Federation

Email: dkostushev@gmail.com

Russian Federation

First Moscow State Medical University Student
Address: 119991, Moscow, Trubetskaya St., 8/2; tel.: (425) 037-08-54

D. A. Gnatenko

A.I. Evdokimov Moscow State Medical Stomatological University Moscow, Russian Federation

Email: gnatenkodmitrii@gmail.com

Russian Federation Intern Researcher of Department of Pathology I.M. Sechenov First Moscow State Medical University
Address: 119991, Moscow, Trubetskaya St., 8/2

M. A. Pal'tsev

National Research Centre «Kurchatov Institute», Moscow, Russian Federation

Email: paltsev_ma@rrcki.ru

Russian Federation

PhD, the Academician of the Russian Academy of Medical Sciences, Professor, Deputy Director for Science of Research Center «Kurchatov Institute» Address: 123182, Moscow, Academician Kurchatov Square, 1; tel.: (499) 196-95-39; fax: (499) 196-17- 04;
e-mail: paltsev_ma@rrcki.ru

  1. Alaoui-Jamali M.A., Xu Y.J. Proteomic technology for biomarker profiling in cancer: an update. J. Zhejiang. Univ. Sci. B. 2006; 6: 411–420.
  2. Vvedenie v molekulyarnuyu diagnostiku. Pod red. M.S. Pal'tseva [Introduction to Molecular Diagnostics. Edited by M.S. Pal'tsev]. Moscow, Meditsina, 2010. 368 p.
  3. Anderson N.L., Anderson N.G. The human plasma proteome: history, character, and diagnostic prospects. Mol. Cell Proteomics. 2002; 11: 845–867.
  4. Sturgeon C. Perspectives in clinical proteomics conference: translating clinical proteomics into clinical practice. Exp. Rev. Proteomics. 2010; 4: 469–471.
  5. McGregor E., Dunn M.J. Proteomics of heart disease. Hum. Mol. Genet. 2003; 2: 135–144.
  6. Edwards A.V., White M.Y., Cordwell S.J. The role of proteomics in clinical cardiovascular biomarker discovery. Mol. Cell Proteomics. 2008; 10: 1824–1837.
  7. Bowler R.P., Ellison M.C., Reisdorph N. Proteomics in pulmonary medicine. Chest. 2006; 2: 567–574.
  8. David P. Carbone, Harvey I. Pass, David H. Johnson. Principles and Practice of Lung Cancer: The Official Reference Text of the IASLC. ISBN 0781773652, 9780781773652.
  9. W J Lemon et al. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. J. Med. Genet. 2002; 39: 644–655.
  10. Gu YM. Elevated thymosin beta15 expression is associated with progression and metastasis of non-small cell lung cancer. APMIS. 2008 Jun;116(6):484-90.
  11. Fatekh-Mogdakham A., Stiebler P. Ratsional'noe ispol'zovanie opukholevykh markerov [Rational Application of Tumor Markers]. Roche Diagnostics. Moscow, 2002. 114 p.
  12. Brennan D.J., O'Connor D.P., Rexhepaj E., Ponten F. Antibody-based proteomics: fast-tracking molecular diagnostics in oncology. Nat. Rev. Cancer. 2010; 9: 605–617.
  13. Golemis E. Protein-protein interactions: A molecular cloning manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press. Ix. 2002. 682 p.
  14. Phizicky E.M., Fields S. Protein-protein interactions: Methods for detection and analysis. Microbiol. Rev. 1995; 59: 94–123.
  15. Berggård T., Linse S., James P. Methods for the detection and analysis of protein-protein interactions. Proteomics. 2007; 16: 2833–2842.

Views

Abstract - 22

PDF (Russian) - 179

Cited-By


PlumX



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies