Immune Landscape Characteristics in Endometriosis

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Abstract

This review is devoted to endometriosis-associated immune cells and immune molecules, analysis of various databases, new insights, theories, biomarkers, reviews of research in this area. To date, many attempts have been made to establish a certain role of immune cells and the microenvironment in the development of endometriosis. Nevertheless, despite intensive studies of endometriosis, the role of inflammatory cells and molecules has not yet been fully studied. As we know, the pathobiology of endometriosis is not fully understood, and its progression is associated with a local and systemic inflammatory reaction. It is important to clarify the role of the immune system to better understand its significance in the pathogenesis of endometriosis, especially in the case of atypical and endometriosis-associated ovarian tumors. The above requires further study of this problem in order to optimize the pathogenetically justified modern therapy of endometriosis.

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About the authors

Olga I. Patsap

Peoples’ Friendship University of Russia

Email: Cleosnake@yandex.ru
ORCID iD: 0000-0003-4620-3922
SPIN-code: 6460-1758

МD, PhD

Russian Federation, Moscow

Marina B. Khabarova

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: khabarovaMB@yandex.ru
ORCID iD: 0000-0003-3526-0366

МD, PhD

Russian Federation, Moscow

Anastasiia A. Buyanova

Pirogov Russian National Research Medical University

Email: anastasiiabuianova97@gmail.com
SPIN-code: 5725-7792
Scopus Author ID: 57218589485
ResearcherId: AGU-7781-2022

Laboratory Assistant

Russian Federation, Moscow

Sergey A. Mikhalev

Pirogov Russian National Research Medical University

Email: mikhalev@me.com
ORCID iD: 0000-0002-4822-0956
SPIN-code: 8105-7908

МD, PhD

Russian Federation, Moscow

Dmitriy A. Atyakshin

Peoples’ Friendship University of Russia

Email: atyakshin-da@rudn.ru
ORCID iD: 0000-0002-8347-4556
SPIN-code: 3830-8152

МD, PhD

Russian Federation, Moscow

Alexandra V. Babkina

City Clinical Oncological Hospital No. 1

Email: nikanorovaalex@gmail.com
ORCID iD: 0000-0001-5485-5803
SPIN-code: 3815-4541

MD

Russian Federation, Moscow

Liudmila M. Mikhaleva

B.V. Petrovsky Russian Scientific Center of Surgery

Author for correspondence.
Email: mikhalevalm@yandex.ru
ORCID iD: 0000-0003-2052-914X
SPIN-code: 2086-7513

МD, PhD, Professor, Corresponding Member of the RAS

Russian Federation, Moscow

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