99mTc-Labelled Low Molecular Weight Inhibitors of Prostate-Specific Membrane Antigen
- Authors: Tishchenko V.K.1, Petriev V.M.1,2, Vlasova O.P.1,3, Pankratov A.A.4, Morozova N.B.4, Shegai P.V.3, Ivanov S.A.1,5, Kaprin A.D.3,4,5
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Affiliations:
- A. Tsyb Medical Radiological Research Centre
- National Research Nuclear University MEPHI (Moscow Engineering Physics Institute)
- National Medical Research Radiological Centre
- P.A. Hertsen Moscow Oncology Research Institute
- RUDN University
- Issue: Vol 77, No 6 (2022)
- Pages: 420-436
- Section: ONCOLOGY: CURRENT ISSUES
- URL: https://vestnikramn.spr-journal.ru/jour/article/view/2207
- DOI: https://doi.org/10.15690/vramn2207
- ID: 2207
Cite item
Abstract
High morbidity and mortality rates of prostate cancer (PCa) determine the requirement of looking for new methods of its early diagnosis. Methods of nuclear medicine have a special place in addressing this problem as they allow functional, metabolic and other processes imaging in body, which occur during the cancer development. This approach supposes the use of radiopharmaceuticals (RP), which are capable of selective binding to a specific biological target, for example, prostate-specific membrane antigen (PSMA), which is known to be overexpressed in PCa. Current development of new radiotracers for PCa imaging is focused on low molecular weight PSMA inhibitors due to their high specific binding to PSMA and rapid urinary excretion. Technetium-99m remains the appropriate radionuclide for diagnostic studies due to its optimal nuclear properties, ease of production and versatile coordination chemistry. Therefore, single-photon emission computed tomography (SPECT) imaging with 99mTc-PSMA radioligands can be a cost effective alternative to PET with 68Ga- or 18F-labeled RP. The aim of this review is to summarize and analyze currently available data on 99mTc-labeled low molecular weight PSMA inhibitors for metastatic PCa imaging.
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About the authors
Viktoriia K. Tishchenko
A. Tsyb Medical Radiological Research Centre
Email: vikshir82@mail.ru
ORCID iD: 0000-0001-8983-5976
SPIN-code: 2724-0930
PhD in Biology
Russian Federation, 4, Korolyova str., 249036, Obninsk, Kaluga RegionVasily M. Petriev
A. Tsyb Medical Radiological Research Centre; National Research Nuclear University MEPHI (Moscow Engineering Physics Institute)
Email: petriev@mrrc.obninsk.ru
ORCID iD: 0000-0002-0231-2177
SPIN-code: 3769-6210
PhD in Biology
Russian Federation, 4, Korolyova str., 249036, Obninsk, Kaluga Region; MoscowOksana P. Vlasova
A. Tsyb Medical Radiological Research Centre; National Medical Research Radiological Centre
Author for correspondence.
Email: somina@inbox.ru
ORCID iD: 0000-0001-5170-9595
SPIN-code: 2554-3985
PhD in Biology
Russian Federation, 4, Korolyova str., 249036, Obninsk, Kaluga Region; Obninsk, Kaluga RegionAndrei A. Pankratov
P.A. Hertsen Moscow Oncology Research Institute
Email: andreimnioi@yandex.ru
ORCID iD: 0000-0001-7291-9743
SPIN-code: 5463-3790
PhD in Biology
Russian Federation, MoscowNatalia B. Morozova
P.A. Hertsen Moscow Oncology Research Institute
Email: n.b.morozova@yandex.ru
ORCID iD: 0000-0002-7159-805X
SPIN-code: 1286-6518
PhD in Biology
Russian Federation, MoscowPetr V. Shegai
National Medical Research Radiological Centre
Email: dr.shegai@mail.ru
ORCID iD: 0000-0001-8901-4596
SPIN-code: 6849-3221
MD, PhD
Russian Federation, Obninsk, Kaluga RegionSergei A. Ivanov
A. Tsyb Medical Radiological Research Centre; RUDN University
Email: oncourolog@gmail.com
ORCID iD: 0000-0001-7689-6032
SPIN-code: 4264-5167
MD, PhD, Professor, Corresponding Member of the RAS
Russian Federation, 4, Korolyova str., 249036, Obninsk, Kaluga Region; MoscowAndrei D. Kaprin
National Medical Research Radiological Centre; P.A. Hertsen Moscow Oncology Research Institute; RUDN University
Email: kaprin@mail.ru
ORCID iD: 0000-0001-8784-8415
SPIN-code: 1759-8101
MD, PhD, Professor, Academician of the RAS
Russian Federation, Obninsk, Kaluga Region; Moscow; MoscowReferences
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