Clinical Anatomical Characteristics of Patients with Rhino-Orbit-Cerebral Mucormycosis

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Background. Postponed coronavirus infection (COVID-19), accompanied by an immunosuppressive state and associated with the risk of secondary diseases such as mucormycosis. Diabetes mellitus is an independent risk factor for both severe COVID-19 and mucormycosis.

Aims — our aim was to experience the diagnosis and treatment of rhino-orbitocerebral mucormycosis in post-COVID-19 patients.

Materials. A single-center, observational, non-randomized, cohort comparative study was conducted. We assessed the clinical features, risk factors, diagnosis and outcomes of mucormycosis among recovered COVID-19 patients with hospitalisation in the otorhinolaryngology department of the Samara State Medical University Clinics, Samara, from September–December 2021. CT examinations were performed on Revolution EVO CT scanner (GE, Russia) and MRI on Aera MR scanner 1.5 T (Siemens, Germany). Materials for microbiological and histopathological examination were taken from all examined patients intraoperatively.

Results. The experience of diagnosing and treating rhinoorbitocerebral mucormycosis in patients after a new coronavirus infection was analyzed, the influence of the complex use of radiation diagnostic methods, histopathological and microbiological methods on the development and effectiveness of mucormycosis treatment was determined.

Conclusions. The effectiveness of disease management directly depends on the early initiation of etiotropic treatment, while the role of complex radiological diagnostics, histopathological and microbiological methods is important for early confirmation of the fungal etiology of the disease.

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About the authors

Alexander V. Kolsanov

Samara State Medical University

ORCID iD: 0000-0002-4144-7090
SPIN-code: 2028-6609

MD, PhD, Professor, Professor RAN

Russian Federation, Samara

Pavel M. Zelter

Samara State Medical University

ORCID iD: 0000-0003-1346-5942
SPIN-code: 3678-3932


Russian Federation, Samara

Olesya V. Zeleva

Samara State Medical University

ORCID iD: 0000-0003-0143-4655
SPIN-code: 8139-1391

заведующая оториноларингологическим отделением, врач-оториноларинголог

Russian Federation, Samara

Olga V. Ivanova

Samara State Medical University

ORCID iD: 0000-0002-4729-6203
SPIN-code: 8806-7177


Russian Federation, Samara

Artem V. Lyamin

Samara State Medical University

ORCID iD: 0000-0002-5905-1895
SPIN-code: 6607-8990

MD, PhD, Associate Professor

Russian Federation, Samara

Egor A. Sidorov

Samara State Medical University

ORCID iD: 0000-0002-2850-8768

врач-рентгенолог рентгенологического отделения клиник

Russian Federation, Samara

Tatiana Yu. Vladimirova

Samara State Medical University

ORCID iD: 0000-0003-1221-5589
SPIN-code: 6725-4931

MD, PhD, Associate Professor

Russian Federation, Samara

Andrey V. Kozlov

Samara State Medical University

ORCID iD: 0000-0001-9384-6854
SPIN-code: 6871-1845

врач-бактериолог клинико-диагностической лаборатории клиник

Russian Federation, Samara

Yulia S. Pyshkina

Samara State Medical University

Author for correspondence.
ORCID iD: 0000-0002-7241-6828
SPIN-code: 4225-1020

MD, PhD, Associate Professor

Russian Federation, 89, Chapayevskaya str., 443099, Samara


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