STUDYING OF HEPATOPROTECTIVE PROPERTIES OF DRY EXTRACT FROM APRICOT LEAVES ON THE MODEL OF LIVER LESION BY TETRACHLOROMETHANE

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Abstract


The results of the pharmacological investigation of the properties of apricot leaves dry extract are indicated in the article. It is proved that the extract belongs to the group of «relatively harmless» substances, exclusion of the ulcerogenic effect on the stomach, local irritating and allergenic effect on animals. It is found minimal reacting dose of the extract, which is 70 mg/kg of body weight. On the model of liver lesion by tetrachlormethane it is proved the antioxidant properties of the extract, which is manifested by the decreasing of the activity of oxidative processes and the resumption of the activity of the endogenous antioxidant system. At the studying of the bile formation and bile secretion functions in the conditions of the toxic tetrachlormethane lesion the hepatoprotective effect of the dosage form was confirmed, which was realized by the increasing of the speed of bile secretion and its volume. It is proved a positive effect of the extract on the detoxification function of the liver, that is confirmed by the reducing of the hexenal sleep in rats after toxicant exposure.


A. L. Shtoblya

Uzhgorod National University, Ukraine

Author for correspondence.
Email: Angela19.12.00@mail.ru

Ukraine ассистент кафедры фармацевтических дисциплин Ужгородского национального университета, соискатель кафедры фармацевтической химии Тернопольского государственного медицинского университета Адрес: 88000, Украина, Ужгород, пл. Народная, д. 1; тел.: 380 (312) 61-24-36

L. S. Fira

I.Ya. Horbachevsky Ternopil State Medical University, Ukraine

Email: ludafira@mail.ru

Ukraine доктор биологических наук, профессор, заведующая кафедрой фармацевтической химии ГВУЗ «Тернопольский государственный медицинский институт им. И.Я. Горбачевского МОНмолодежьспорта Украины» Адрес: 46000, Украина, Тернополь, майдан Воли, д. 1; тел.: 380 (352) 52-43-37

P. G. Likhatskii

I.Ya. Horbachevsky Ternopil State Medical University, Ukraine

Email: luhatsky@mail.ru

Ukraine кандидат биологических наук, доцент кафедры фармацевтической химии ГВУЗ «Тернопольский государственный медицинский институт им. И.Я. Горбачевского» Адрес: 46000, Украина, Тернополь, майдан Воли, д. 1; тел.: 380 (352) 52-43-37

V. P. Pyda

I.Ya. Horbachevsky Ternopil State Medical University, Ukraine

Email: pyda_vp@mail.ru

Ukraine кандидат фармацевтических наук, ассистент кафедры фармакологии ГВУЗ «Тернопольский государственный медицинский институт им. И.Я. Горбачевского» Адрес: 46000, Украина, Тернополь, майдан Воли, д. 1; тел.: 380 (352) 52-39-87

E. M. Vashkeba

Uzhgorod National University, Ukraine

Email: vevi@meta.ua

Ukraine кандидат медицинских наук, ассистент кафедры фармацевтических дисциплин Ужгородского национального университета Адрес: 88000, Украина, Ужгород, пл. Народная, д. 1; тел.: 380 (312)61-24-36

I. I. Medvid'

I.Ya. Horbachevsky Ternopil State Medical University, Ukraine

Email: irunamedvid@mail.ru

Ukraine ассистент кафедры фармацевтической химии ГВУЗ «Тернопольский государственный медицинский институт им. И.Я. Горбачевского» Адрес: 46000, Украина, Тернополь, майдан Воли, д. 1; тел.: 380 (352) 52-43-37

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