Non-Invasive Prenatal Testing: the International Experience of Medical and Economic NIPT Efficiency Evaluation

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Abstract

Non-invasive prenatal testing (NIPT) is a molecular genetic method of cell-free fetal DNA fetal chromosomal abnormalities risks assessing. Currently, NIPT is quite widespread throughout the world, and its clinical efficacy — high sensitivity and specificity — has been repeatedly proven. At the same time, the decision to include NIPT in the algorithm of prenatal diagnostics carried out with public funds depends on its cost-effectiveness, which should be assessed separately for each country or territory due to different costs and different models of inclusion. This article presents the different countries approaches to the assessment of the medical and economic efficiency of NIPT.

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About the authors

Madina T. Kaplanova

LLC “Evogen”

Author for correspondence.
Email: kaplanova@evogenlab.ru
ORCID iD: 0000-0001-6715-706X
SPIN-code: 7152-6514

MD

Russian Federation, 20, bldn. 1, 4th Roshchinsky passage, 115191, Moscow

Alexandra M. Galaktionova

LLC “Evogen”

Email: galaktionova@evogenlab.ru
ORCID iD: 0000-0001-8602-5441
SPIN-code: 6112-9060

MD, PhD

Russian Federation, Moscow

Elena E. Baranova

LLC “Evogen”; Russian Medical Academy of Continuous Professional Education

Email: baranova@evogenlab.ru
ORCID iD: 0000-0001-9638-2303
SPIN-code: 3163-6666
Scopus Author ID: 57191922075

MD, PhD

Russian Federation, Moscow; Moscow

Olesya V. Sagaydak

LLC “Evogen”

Email: sagaydak@evogenlab.ru
ORCID iD: 0000-0002-2534-8463
SPIN-code: 5996-6327

MD, PhD

Russian Federation, Moscow

Maksim S. Belenikin

LLC “Evogen”

Email: belenikin@evogenlab.ru
ORCID iD: 0000-0002-6556-163X

PhD in Chemical

Russian Federation, Moscow

Alexey G. Denisov

Health Department of the Yamalo-Nenets Autonomous Okrug; Salekhard District Clinical Hospital

Email: denisovag@yandex.ru

MD, PhD

Russian Federation, Salekhard; Salekhard

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