The Osteoinductive Potential of Partially Demineralized Bone Matrix and the Possibility of Its Use in Clinical Practice

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Abstract

Today autografts are considered to be an optimal material for bone grafting. However, the collection of material and it’s clinical use is associated with several serious drawbacks, and therefore, in reconstructive surgery, a search for alternative treatment approaches is being conducted. A bone transplant from another person (allo-osteoplasty) is the most natural and logical option for replacing an autobone. Since 1965, allogeneic implants of a partially demineralized bone matrix combining osteoinductive and osteoconductive action have been used in clinical practice. However, the clinical results of the use of this material turned out to be ambiguous, which is due, first of all, to the significant variability of the osteoplastic potential of its various samples. For this reason, in clinical practice, sometimes preference is given to samples of non-demineralized allobone, which retain it’s structure longer. In this paper, we consider factors affecting the osteoinductive activity of a partially demineralized bone matrix, related both to the technological issues of its preparation and to the clinical conditions of use. Issues of the possible improvement of this material were discussed with a view to its further use in medical practice.

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About the authors

Alexander S. Pankratov

I.M. Sechenov First Moscow State Medical University (Sechenov University); Russian Medical Academy of Continuing Professional Education

Email: stomat-2008@mail.ru
ORCID iD: 0000-0001-9620-3547
SPIN-code: 9785-2632

MD, PhD, Assistant Professor

Russian Federation, 8 bld. 2, Trubetskaya str., 119991, Moscow; Moscow

Irina S. Fadeeva

Institute of Theoretical and Experimental Biophysics RAS

Email: fadeeva.iteb@gmail.com
ORCID iD: 0000-0002-1709-9970
SPIN-code: 6475-1023

PhD in Biology

Russian Federation, Pushchino-on-Oka, Moscow Region

Yulia B. Yurasova

National Medical Research Center for Traumatology and Orthopedics Named after N.N. Priorov

Email: yyrasova@gmail.com
ORCID iD: 0000-0001-8398-6829

MD, PhD, Assistant Professor

Russian Federation, 8 bld. 2, Trubetskaya str., 119991, Moscow

Vasily M. Grinin

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: grynin@mail.ru
ORCID iD: 0000-0002-2280-8559
SPIN-code: 9663-2378
Scopus Author ID: 7005966400
ResearcherId: U-7910-2019

MD, PhD, Professor

Russian Federation, 8 bld. 2, Trubetskaya str., 119991, Moscow

Igor V. Cherkesov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: cherkesovi@gmail.com
ORCID iD: 0000-0002-4336-4459

MD, PhD

Russian Federation, 8 bld. 2, Trubetskaya str., 119991, Moscow

Vasily V. Korshunov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: korshunov140395@mail.ru
ORCID iD: 0000-0001-6497-0637

MD

Russian Federation, 8 bld. 2, Trubetskaya str., 119991, Moscow

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Supplementary files

Supplementary Files
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1. Fig. 1. Technological stages of manufacturing demineralized bone matrix

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2. Fig. 2. Forms of demineralized bone matrix used in clinical practice

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