ASSOCIATION OF POLYMORPHISM RS6737848 IN THE SOCS5 GENE WITH BRONCHIAL ASTHMA

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Abstract

Aim: to investigate the role of polymorphic variants of immune-response modifying genes in predisposition to asthma. Patients and methods. The analysis of restriction fragments length polymorphism was used to investigate 10 single-nucleotide polymorphisms: IFNG rs2069705, IFNGR2 rs17880053, IL4 rs 2070874, IL4RA rs 1805010, GATA3 rs10905277, TBX21 rs11652969, PIASY rs3760903, PIAS3 rs12756687, STAT5β rs16967593, and SOCS5 rs6737848 in 106 asthma patients and 115 healthy people. Results. The rs6737848 SOCS5 polymorphism was significantly associated with asthma in additive model (р =0,05, OR =0,338, 95%CI 0,158–0,723) and in dominant model (р =0,02, OR =0,284, CI 0,126–0,638). None of the polymorphisms of the studied genes was associated with total IgE levels. Conclusions. This is the first report on the association of rs6737848 SOCS5 with asthma.

 

About the authors

I. V. Saltykova

Siberian State Medical University, Tomsk, Russian Federation

Author for correspondence.
Email: ira.saltikova@mail.ru
PhD, Junior Research Worker, Central Research Laboratory of Siberian State Medical University Address: 634050, Tomsk, Moscow path, 2; tel.: (3822) 52-99-16 Россия

M. B. Freidin

Research Institute of Medical Genetics, Tomsk, Russian Federation

Email: mfreidin@medgenetics.ru
PhD, Senior Research Worker, Laboratory of Population Genetics, Research Institute of Medical Genetics SB RAMS Address: 634050, Tomsk, Naberezhnaya Reki Ushayki St., 10; tel.: (3822) 42-09-56 Россия

E. Yu. Bragina

Research Institute of Medical Genetics, Tomsk, Russian Federation

Email: elena.bragina72@gmail.com
PhD, Research Worker, Laboratory of Population Genetics, Research Institute of Medical Genetics SB RAMS Address: 634050, Tomsk, Naberezhnaya Reki Ushayki St., 10; tel.: (3822) 42-09-56 Россия

L. M. Ogorodova

Siberian State Medical University, Tomsk, Russian Federation

Email: lm.ogorodova@mail.ru
PhD, Professor, RAMS cor. member, Head of the Pediatrics Department of the Medical Faculty with Children's Diseases Course, Siberian State Medical University Address: 634050, Tomsk, Moscow path, 2; tel.: (3822) 53-10-22 Россия

V. P. Puzyrev

Research Institute of Medical Genetics, Tomsk, Russian Federation

Email: valery.puzyrev@medgenetics.ru
PhD, Professor, RAMS academician, Director of the Research Institute of Medical Genetics SB RAMS, Head of the Laboratory of Population Genetics Research Institute of Medical Genetics SB RAMS Address: 634050, Tomsk, Naberezhnaya Reki Ushayki St., 10; tel.: (3822) 51-22-28 Россия

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