ASSOCIATION OF POLYMORPHISM RS6737848 IN THE SOCS5 GENE WITH BRONCHIAL ASTHMA

Cover Page

Abstract


Aim: to investigate the role of polymorphic variants of immune-response modifying genes in predisposition to asthma. Patients and methods. The analysis of restriction fragments length polymorphism was used to investigate 10 single-nucleotide polymorphisms: IFNG rs2069705, IFNGR2 rs17880053, IL4 rs 2070874, IL4RA rs 1805010, GATA3 rs10905277, TBX21 rs11652969, PIASY rs3760903, PIAS3 rs12756687, STAT5β rs16967593, and SOCS5 rs6737848 in 106 asthma patients and 115 healthy people. Results. The rs6737848 SOCS5 polymorphism was significantly associated with asthma in additive model (р =0,05, OR =0,338, 95%CI 0,1580,723) and in dominant model (р =0,02, OR =0,284, CI 0,1260,638). None of the polymorphisms of the studied genes was associated with total IgE levels. Conclusions. This is the first report on the association of rs6737848 SOCS5 with asthma.

 


I. V. Saltykova

Siberian State Medical University, Tomsk, Russian Federation

Author for correspondence.
Email: ira.saltikova@mail.ru

Russian Federation PhD, Junior Research Worker, Central Research Laboratory of Siberian State Medical University Address: 634050, Tomsk, Moscow path, 2; tel.: (3822) 52-99-16

M. B. Freidin

Research Institute of Medical Genetics, Tomsk, Russian Federation

Email: mfreidin@medgenetics.ru

Russian Federation PhD, Senior Research Worker, Laboratory of Population Genetics, Research Institute of Medical Genetics SB RAMS Address: 634050, Tomsk, Naberezhnaya Reki Ushayki St., 10; tel.: (3822) 42-09-56

E. Yu. Bragina

Research Institute of Medical Genetics, Tomsk, Russian Federation

Email: elena.bragina72@gmail.com

Russian Federation PhD, Research Worker, Laboratory of Population Genetics, Research Institute of Medical Genetics SB RAMS Address: 634050, Tomsk, Naberezhnaya Reki Ushayki St., 10; tel.: (3822) 42-09-56

L. M. Ogorodova

Siberian State Medical University, Tomsk, Russian Federation

Email: lm.ogorodova@mail.ru

Russian Federation PhD, Professor, RAMS cor. member, Head of the Pediatrics Department of the Medical Faculty with Children's Diseases Course, Siberian State Medical University Address: 634050, Tomsk, Moscow path, 2; tel.: (3822) 53-10-22

V. P. Puzyrev

Research Institute of Medical Genetics, Tomsk, Russian Federation

Email: valery.puzyrev@medgenetics.ru

Russian Federation PhD, Professor, RAMS academician, Director of the Research Institute of Medical Genetics SB RAMS, Head of the Laboratory of Population Genetics Research Institute of Medical Genetics SB RAMS Address: 634050, Tomsk, Naberezhnaya Reki Ushayki St., 10; tel.: (3822) 51-22-28

  1. March M.E, Sleiman P.M, Hakonarson H. The genetics of asthma and allergic disorders. Discov. Med. 2011; 11 (56): 35–45.
  2. Ege M.J., Mayer M., Schwaiger K. et al. Environmental bacteria and childhood asthma. Allergy. 2012; 67 (12): 1565–1571.
  3. Hilty M., Burke C., Pedro H. et al. Disordered microbial communities in asthmatic airways. PLoS One. 2010; 5 (1): 8578.
  4. Nakao F., Ihara K., Kusuhara K. et al. Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma. J. Allergy Clin. Immunol. 2001; 107 (3): 499–504.
  5. Nieters A., Brems S., Becker N. Cross-sectional study on cytokine polymorphisms, cytokine production after T-cell stimulation and clinical parameters in a random sample of a German population. Hum. Genet. 2001; 108 (3): 241–248.
  6. Nagarkatti R., Rao C.B., Rishi J.P. et al. Association of IFNG gene polymorphism with asthma in the Indian population. J. Allergy Clin. Immunol. 2002; 110 (3): 410–412.
  7. Li Y., Wu B., Xiong H. et al. Polymorphisms of STAT-6, STAT-4 and IFN-gamma genes and the risk of asthma in Chinese population. Respir. Med. 2007; 101 (9): 1977–1981.
  8. Hsieh Y.Y., Wan L., Chang C.C. et al. STAT2*C related genotypes and allele but not TLR4 and CD40 gene polymorphisms are associated with higher susceptibility for asthma. Int. J. Biol. Sci. 2009; 5 (1): 74–81.
  9. Wormald S, Hilton DJ. Inhibitors of cytokine signal transduction. J. Biol. Chem. 2004; 279 (2): 821-824.
  10. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. Royal Statistic. Soc., Series B (Methodological). 1995; 57 (1): 289–300.
  11. Daegelmann C., Herberth G., Rцder S. et al. Association between suppressors of cytokine signalling, T-helper type 1/T-helper type 2 balance and allergic sensitization in children. Clin. Exp. Allergy. 2008; 38 (3): 438–448.
  12. Ohshima M., Yokoyama A., Ohnishi H. et al. Overexpression of suppressor of cytokine signalling-5 augments eosinophilic airway inflammation in mice. Clin. Exp. Allergy. 2007; 37 (5): 735–742.
  13. Le Cras T.D., Acciani T.H., Mushaben E.M. et al. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am. J. Physiol. Lung Cell Mol. Physiol. 2011; 300 (3): 414–421.

Views

Abstract - 32

PDF (Russian) - 21

Cited-By


PlumX

Dimensions



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies