Retrospective Cross-Sectional Epidemiological Study of Human Papillomavirus-Associated Precancers and Anogenital Warts in Patients Attending Specialized Clinics in Russian Federation

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Background. In Russia, there are no country level registries on HPV-associated pre-cancers (cervical intraepithelial neoplasia, CIN; vulvar intraepithelial neoplasia, VIN; vaginal intraepithelial neoplasia, VaIN; anal intraepithelial neoplasia, AIN; penile intraepithelial neoplasia PIN) and anogenital warts (AWs) and no national-level cervical cancer screening program.

Aims — the aim of this study was to assess the proportion of patients with CIN, VIN, VaIN, AIN, PIN and AWs diagnosis in the clinical settings in Russia.

Methods. This study was a non-interventional retrospective multi-center chart-review study in 28 investigational sites representing 21 Federal subjects of 6 Federal Districts of Russia. Medical charts of adult men and women visited gynecology, sexual health, dermatovenerology or urology services between 1 Jan 2000 — 31 Dec 2019 were reviewed. Data were abstracted, using a standardized approach, on patient demographic characteristics, presence or absence of pre-cancers and AWs diagnoses, method of diagnosing pre-cancer and HPV infection, and grade of neoplasia.

Results. A total of 11 520 patients (1732 male and 9788 female) were included in the analysis. The overall proportion of patients with HPV-associated precancers and AWs was 10.8%. By service type, cases of HPV-associated conditions were revealed most often in dermatological departments (14.5%) and gynecological hospitals (13.8%). CIN detection rate in Russian clinical settings increased over the 20-years from 3.2 to 11.1% and was higher in gynecological in-patient departments compared to out-patient departments (12.5 and 5.2% respectively). The number of non-cervical precancers (VIN, VaIN, AIN, PIN) cases were very low (the detection rate was less than 1%). The frequency of HPV type 16 and 18 detection increased from 0.6 to 4.8%, and from 0.2 to 1.9%, respectively, for the 20-years period.

Conclusions. Our study suggested high level of HPV-related pre-cancer and AW disease burden as well as presence of high-risk HPV types. Preventive strategy through effective national HPV immunization program would be beneficial to reduce HPV-related disease burden in Russia.

Full Text

Restricted Access

About the authors

Nikolay I. Briko

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: briko_n_i@staff.sechenov.ru
ORCID iD: 0000-0002-6446-2744
SPIN-code: 2992-6915

MD, PhD, Professor, Academician of the RAS

Russian Federation, Moscow

Platon D. Lopukhov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: Lopukhov_p_d@staff.sechenov.ru
ORCID iD: 0000-0002-0872-2214
SPIN-code: 1250-6839

MD, PhD

Russian Federation, Moscow

Nina V. Zarochentseva

Moscow Regional Research Institute of Obstetrics and Gynecology

Author for correspondence.
Email: ninazar11@mail.ru
ORCID iD: 0000-0001-6155-788X
SPIN-code: 4737-5826

MD, PhD, Professor

Russian Federation, Moscow

Igor I. Baranov

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov

Email: i_baranov@oparina4.ru
ORCID iD: 0000-0002-9813-2823
SPIN-code: 4224-0437

MD, PhD, Professor

Russian Federation, Moscow

Olga V. Kachalina

Privolzhsky Research Medical University

Email: yandr24@bk.ru
ORCID iD: 0000-0002-6218-8614
SPIN-code: 9730-3930

MD, PhD, Professor

Russian Federation, Nizhny Novgorod

Oleg R. Ziganshin

Chelyabinsk Regional Clinical Dermatovenerologic Dispensary

Email: ziganshin_oleg@mail.ru
ORCID iD: 0000-0002-5857-0319
SPIN-code: 5339-2533

MD, PhD, Professor

Russian Federation, Chelyabinsk

Andrey A. Shuldyakov

Saratov State Medical University

Email: shuldaykov@mail.ru
ORCID iD: 0000-0002-3009-9262
SPIN-code: 1157-7585

MD, PhD, Professor

Russian Federation, Saratov

References

  1. Ferlay J, Colombet M, Soerjomataram I, et al. Cancer statistics for the year 2020: An overview. Int J Cancer. 2021;149:778–789. doi: https://doi.org/10.1002/ijc.33588
  2. Каприн А.Д., Аполихин О.И., Сивков А.В., и др. Междисциплинарный подход к улучшению репродуктивного здоровья подростков и взрослого населения // Эпидемиология и вакцинопрофилактика. — 2022. — Т. 21. — № 1. — С. 103–109. [Kaprin AD, Apolikhin OI, Sivkov AV, et al. Interdisciplinary Approach to Improving the Reproductive Health of Adolescents and Adults. Epidemiology and Vaccinal Prevention. 2022;21(1):103–109. (In Russ.)] doi: https://doi.org/10.31631/2073-3046-2022-21-1-103-109
  3. Баранов А.А., Намазова-Баранова Л.С., Таточенко В.К., и др. Вакцинопрофилактика заболеваний, вызванных вирусом папилломы человека: позиции доказательной медицины // Обзор клинических рекомендаций. Вопросы современной педиатрии. — 2017. — T. 16. — № 2. — C. 107–117. [Baranov AА, Namazova-Baranova LS, Tatochenko VK, et al. Vaccinal Prevention of the Diseases Caused by Human Papillomavirus: Evidence-Based Medicine. Review of Clinical Guidelines. Current Pediatrics. 2017;16(2):107–117. (In Russ.)] doi: https://doi.org/10.15690/vsp.v1
  4. de Villiers EM, Fauquet C, Broker TR, et al. Classification of papillomaviruses. Virology. 2004;324(1):17–27. doi: https://doi.org/10.1016/j.virol.2004.03.033
  5. Bernard HU, Burk RD, Chen Z, et al. Classification of papillomaviruses (PVs) based on 189 PV types and proposal oftaxonomic amendments. Virology. 2010;401(1):70–79. doi: https://doi.org/10.1016/j.virol.2010.02.002
  6. Cogliano V, Baan R, Straif K, et al. Carcinogenicity of human papillomaviruses. Lancet Oncology. 2005;6(4):204. doi: https://doi.org/10.1016/s1470-2045(05)70086-3
  7. de Martel C, Georges D, Bray F, et al. Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. Lancet Glob Health. 2020;8(2):e180–e190. doi: https://doi.org/10.1016/S2214-109X(19)30488-7
  8. Bräutigam K, Meier S, Meneder S, et al. Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix. Cancers (Basel). 2022;14(13):3136. doi: https://doi.org/10.3390/cancers14133136
  9. Fairley CK, Donovan B. What can surveillance of genital warts tell us? Sex Health. 2010;7(3):325–327. doi: https://doi.org/10.1071/SH09145
  10. Брико Н.И., Лопухов П.Д., Каприн А.Д., и др. ВПЧ-ассоциированные поражения в Российской Федерации: оценка состояния проблемы // Современная онкология. — 2019. — Т. 21. — № 1. — С. 45–50. [Briko NI, Lopukhov PD, Kaprin AD, et al. HPV-associated lesions in the Russian Federation: assessment of the problem. Journal of Modern Oncology. 2019;21(1):45–50. (In Russ.)] doi: https://doi.org/10.26442/18151434.2019.190199
  11. Каприн А.Д., Новикова Е.Г., Трушина О.И., и др. Скрининг рака шейки матки — нерешенные проблемы // Исследования и практика в медицине. — 2015. — Т. 2. — № 1. — С. 36–41. [Kaprin AD, Novikova EG, Trushina OI, et al. The cervical cancer screening — unsolved problems. Research and Practical Medicine Journal. 2015;2(1):36–41. (In Russ.)] doi: https://doi.org/10.17709/2409-2231-2015-2-1-36-41
  12. McCredie MR, Sharples KJ, Paul C, et al. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncol. 2008;9(5):425–434. doi: https://doi.org/10.1016/S1470-2045(08)70103-7
  13. Bruni L, Albero G, Serrano B, et al. ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in the World. Summary Report 10 March 2023.
  14. Bosch FX, Robles C, Díaz M, et al. HPV-FASTER: broadening the scope for prevention of HPV-related cancer. Nat Rev Clin Oncol. 2016;13(2):119–132. doi: https://doi.org/10.1038/nrclinonc.2015.146
  15. Кубанов А.А., Богданова Е.В. Динамика заболеваемости инфекциями, передаваемыми половым путем, в различных группах взрослого населения Российской Федерации в 2011–2019 годах // Инфекционные болезни. — 2020. — Т. 18. — № 4. — С. 58–73. [Kubanov AA, Bogdanova EV. Dynamics of the incidence of sexually transmitted infections in different groups of the adult population in the Russian Federation in 2011–2019. Infekc. bolezni (Infectious diseases). 2020;18(4):58–73. (In Russ.)] doi: https://doi.org/10.20953/1729-9225-2020-4-58-73
  16. Lei J, Ploner A, Miriam Elfström K, et al. HPV Vaccination and the Risk of Invasive Cervical Cancer. N Engl J Med. 2020;383(14):1340–1348. doi: https://doi.org/10.1056/NEJMoa1917338
  17. Machalek DA, Garland SM, Brotherton JML, et al. Very Low Prevalence of Vaccine Human Papillomavirus Types Among 18- to 35-Year-Old Australian Women 9 Years Following Implementation of Vaccination. J Infect Dis. 2018;217(10):1590–1600. doi: https://doi.org/10.1093/infdis/jiy075

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 "Paediatrician" Publishers LLC



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies