Retrospective Cross-Sectional Epidemiological Study of Human Papillomavirus-Associated Precancers and Anogenital Warts in Patients Attending Specialized Clinics in Russian Federation

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Abstract

Background. In Russia, there are no country level registries on HPV-associated pre-cancers (cervical intraepithelial neoplasia, CIN; vulvar intraepithelial neoplasia, VIN; vaginal intraepithelial neoplasia, VaIN; anal intraepithelial neoplasia, AIN; penile intraepithelial neoplasia PIN) and anogenital warts (AWs) and no national-level cervical cancer screening program.

Aims — the aim of this study was to assess the proportion of patients with CIN, VIN, VaIN, AIN, PIN and AWs diagnosis in the clinical settings in Russia.

Methods. This study was a non-interventional retrospective multi-center chart-review study in 28 investigational sites representing 21 Federal subjects of 6 Federal Districts of Russia. Medical charts of adult men and women visited gynecology, sexual health, dermatovenerology or urology services between 1 Jan 2000 — 31 Dec 2019 were reviewed. Data were abstracted, using a standardized approach, on patient demographic characteristics, presence or absence of pre-cancers and AWs diagnoses, method of diagnosing pre-cancer and HPV infection, and grade of neoplasia.

Results. A total of 11 520 patients (1732 male and 9788 female) were included in the analysis. The overall proportion of patients with HPV-associated precancers and AWs was 10.8%. By service type, cases of HPV-associated conditions were revealed most often in dermatological departments (14.5%) and gynecological hospitals (13.8%). CIN detection rate in Russian clinical settings increased over the 20-years from 3.2 to 11.1% and was higher in gynecological in-patient departments compared to out-patient departments (12.5 and 5.2% respectively). The number of non-cervical precancers (VIN, VaIN, AIN, PIN) cases were very low (the detection rate was less than 1%). The frequency of HPV type 16 and 18 detection increased from 0.6 to 4.8%, and from 0.2 to 1.9%, respectively, for the 20-years period.

Conclusions. Our study suggested high level of HPV-related pre-cancer and AW disease burden as well as presence of high-risk HPV types. Preventive strategy through effective national HPV immunization program would be beneficial to reduce HPV-related disease burden in Russia.

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About the authors

Nikolay I. Briko

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: briko_n_i@staff.sechenov.ru
ORCID iD: 0000-0002-6446-2744
SPIN-code: 2992-6915

MD, PhD, Professor, Academician of the RAS

Россия, Moscow

Platon D. Lopukhov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: Lopukhov_p_d@staff.sechenov.ru
ORCID iD: 0000-0002-0872-2214
SPIN-code: 1250-6839

MD, PhD

Россия, Moscow

Nina V. Zarochentseva

Moscow Regional Research Institute of Obstetrics and Gynecology

Author for correspondence.
Email: ninazar11@mail.ru
ORCID iD: 0000-0001-6155-788X
SPIN-code: 4737-5826

MD, PhD, Professor

Россия, Moscow

Igor I. Baranov

National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov

Email: i_baranov@oparina4.ru
ORCID iD: 0000-0002-9813-2823
SPIN-code: 4224-0437

MD, PhD, Professor

Россия, Moscow

Olga V. Kachalina

Privolzhsky Research Medical University

Email: yandr24@bk.ru
ORCID iD: 0000-0002-6218-8614
SPIN-code: 9730-3930

MD, PhD, Professor

Россия, Nizhny Novgorod

Oleg R. Ziganshin

Chelyabinsk Regional Clinical Dermatovenerologic Dispensary

Email: ziganshin_oleg@mail.ru
ORCID iD: 0000-0002-5857-0319
SPIN-code: 5339-2533

MD, PhD, Professor

Россия, Chelyabinsk

Andrey A. Shuldyakov

Saratov State Medical University

Email: shuldaykov@mail.ru
ORCID iD: 0000-0002-3009-9262
SPIN-code: 1157-7585

MD, PhD, Professor

Россия, Saratov

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