Menopause and Hyperuricemia in Women in the Russian Population (Results of the ESSE-RF Study)

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Abstract

Aims. To evaluate the relationship of menopause and its features with hyperuricemia in Russian women. Methods. In this study, we used data from the cross-sectional phase of the epidemiological study “Epidemiology of Cardiovascular Diseases in the Regions of the Russian Federation” (ESSE-RF) conducted in 2013–2014, in 13 regions of Russia. The final random sample size was 12 781 women. According to the interviews, the fact of menopause and the features of climacteric were identified. Hyperuricemia was defined as a serum uric acid concentration greater than 360 μmol/L. Age, behavioral risk factors and indicators of health status were assessed as covariates. Logistic regression analysis was used for multivariate assessment of associations. Apart from the assessment of the general sample, the analysis of the groups stratified by obesity, diabetes mellitus and the characteristics of climacteric was carried out. The results of logistic regression analysis are presented as odds ratios (OR) and 95% confidence intervals (CI). Results. In the general sample, after adjusting for covariates, menopause was directly associated with hyperuricemia (OR = 1.17; 95% CI 1.06–1.28), the association of hyperuricemia with age was not statistically significant. Menopause was more consistently associated with hyperuricemia in obese compared to non-obese women. In diabetic women, menopause is directly and significantly associated with hyperuricemia, whereas in non-diabetic women there was not the association between menopause and hyperuricemia. Taking into account the features of climacteric, menopause was directly associated with hyperuricemia only in the 4–10 years after the onset of menopause (OR = 1.13; 95% CI 1.02–1.26), in natural menopausal women (OR = 1.18; 95% CI 1.07–1.30) and who were taking hormone replacement therapy (OR = 1.23; 95% CI 1.06–1.43). Conclusions. The results of the study indicate the direct association of hyperuricemia with menopause, but not with the age of women. The stratified analysis has made it possible to identify some features of the association between hyperuricemia and menopause in women with metabolic disorders, as well as to assess the influence of the features of climacteric.

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About the authors

Sergey A. Maksimov

National Medical Research Center for Therapy and Preventive Medicine

Email: m1979sa@yandex.ru
ORCID iD: 0000-0003-0545-2586
SPIN-code: 4362-1967
Scopus Author ID: 25958772000

MD, PhD, Assistant Professor

Russian Federation, 10 bld. Petroverigskiy lane, 101990, Moscow

Svetlana A. Shalnova

National Medical Research Center for Therapy and Preventive Medicine

Email: sshalnova@gnicpm.ru
ORCID iD: 0000-0003-2087-6483
SPIN-code: 9189-8637
Scopus Author ID: 6603427718

MD, PhD, Professor

Russian Federation, 10 bld. Petroverigskiy lane, 101990, Moscow

Galina A. Muromceva

National Medical Research Center for Therapy and Preventive Medicine

Email: GMuromtseva@gnicpm.ru
ORCID iD: 0000-0002-0240-3941
SPIN-code: 9872-8010
Scopus Author ID: 6507150084

PhD in Biology

Russian Federation, 10 bld. Petroverigskiy lane, 101990, Moscow

Anna V. Kapustina

National Medical Research Center for Therapy and Preventive Medicine

Email: AKapustina@gnicpm.ru
ORCID iD: 0000-0002-9624-9374
SPIN-code: 1280-2172
Scopus Author ID: 7003586346
Russian Federation, 10 bld. Petroverigskiy lane, 101990, Moscow

Asiya E. Imaeva

National Medical Research Center for Therapy and Preventive Medicine

Email: AImaeva@gnicpm.ru
ORCID iD: 0000-0002-9332-0622
SPIN-code: 7568-9285
Scopus Author ID: 47461141600

MD, PhD

Russian Federation, 10 bld. Petroverigskiy lane, 101990, Moscow

Svetlana E. Evstifeeva

National Medical Research Center for Therapy and Preventive Medicine

Email: SEvstifeeva@gnicpm.ru
ORCID iD: 0000-0002-7486-4667
SPIN-code: 3706-2581
Scopus Author ID: 6505781753

MD, PhD

Russian Federation, 10 bld. Petroverigskiy lane, 101990, Moscow

Yulia A. Balanova

National Medical Research Center for Therapy and Preventive Medicine

Email: JBalanova@gnicpm.ru
ORCID iD: 0000-0001-8011-2798
SPIN-code: 7417-2194
Scopus Author ID: 6506216400

MD, PhD

Russian Federation, 10 bld. Petroverigskiy lane, 101990, Moscow

Natalia S. Karamnova

National Medical Research Center for Therapy and Preventive Medicine

Email: NKaramnova@gnicpm.ru
ORCID iD: 0000-0002-8604-712X
SPIN-code: 2878-3016
Scopus Author ID: 30467802000

MD, PhD

Russian Federation, 10 bld. Petroverigskiy lane, 101990, Moscow

Aleksandra O. Konradi

Almazov National Medical Research Centre

Email: konradi@almazovcenre.ru
ORCID iD: 0000-0001-8169-7812
SPIN-code: 2298-8269
Scopus Author ID: 7004144504

MD, PhD, Professor, Corresponding Member of the RAS

Russian Federation, St. Petersburg

Sergey A. Bojcov

National Medical Research Center of Cardiology; A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Email: info@cardioweb.ru
ORCID iD: 0000-0001-6998-8406
SPIN-code: 7961-5520
Scopus Author ID: 56580221300

MD, PhD, Professor, Academician of the RAS

Russian Federation, 10 bld., Petroverigskiy lane, 101990, Moscow; Moscow

Oksana M. Drapkina

National Medical Research Center for Therapy and Preventive Medicine

Author for correspondence.
Email: ODrapkina@gnicpm.ru
ORCID iD: 0000-0002-4453-8430
SPIN-code: 4456-1297
Scopus Author ID: 57208852308

MD, PhD, Professor, Corresponding Member of the RAS

Russian Federation, 10 bld. Petroverigskiy lane, 101990, Moscow

References

  1. Li M, Hou W, Zhang X, et al. Hyperuricemia and risk of stroke: A systematic review and meta-analysis of prospective studies. Atherosclerosis. 2014;232(2):265–270. doi: https://doi.org/10.1016/j.atherosclerosis.2013.11.051
  2. Cheserek MJ, Shi Y, Le G. Association of hyperuricemia with metabolic syndrome among university workers: sex and occupational differences. Afr Health Sci. 2018;18(4):842–851. doi: https://doi.org/10.4314/ahs.v18i4.2
  3. Katsiki N, Papanas N, Fonseca VA, et al. Uric acid and diabetes: Is there a link? Curr Pharm Des. 2013;19(27):4930–4937. doi: https://doi.org/10.2174/1381612811319270016
  4. Chen-Xu M, Yokose C, Rai SK, et al. Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: The National Health and Nutrition Examination Survey, 2007–2016. Arthritis Rheumatol. 2019;71(6):991–999. doi: https://doi.org/10.1002/art.40807
  5. Robinson PC, Taylor WJ, Merriman TR. Systematic review of the prevalence of gout and hyperuricaemia in Australia. Intern Med J. 2012;42(9):997–1007. doi: https://doi.org/10.1111/j.1445-5994.2012.02794.x
  6. Liu R, Han C, Wu D, et al. Prevalence of hyperuricemia and gout in Mainland China from 2000 to 2014: A systematic review and meta-analysis. Biomed Res Int. 2015;2015:762820. doi: https://doi.org/10.1155/2015/762820
  7. Kumar AUA, Browne LD, Li X, et al. Temporal trends in hyperuricaemia in the Irish health system from 2006-2014: A cohort study. PLoS One. 2018;13(5):e0198197. doi: https://doi.org/10.1371/journal.pone.0198197
  8. Шальнова С.А., Деев А.Д., Артамонова Г.В., и др. Гиперурикемия и ее корреляты в российской популяции (результаты эпидемиологического исследования ЭССЕ-РФ) // Рациональная фармакотерапия в кардиологии. — 2014. — Т. 10. — № 2. — С. 153–159. [Shalnova SA, Deev AD, Artamonov GV, et al. Hyperuricemia and its correlates in the Russian population (results of ESSE-RF epidemiological study). Rational Pharmacotherapy in Cardiology. 2014;10(2):153–159. (In Russ.)]. doi: https://doi.org/10.20996/1819-6446-2014-10-2-153-159
  9. Maksimov SA, Shalnova SA, Balanova YA, et al. Hyperuricemia versus lifestyle in men and women of the Russian Federation population. Russian Open Medical Journal. 2020;9(2):e0214. doi: https://doi.org/10.15275/rusomj.2020.0214
  10. Hak AE, Choi HK. Menopause, postmenopausal hormone use and serum uric acid levels in US women — the Third National Health and Nutrition Examination Survey. Arthritis Res Ther. 2008;10(5):R116. doi: https://doi.org/10.1186/ar2519
  11. Akizuki S. Serum uric acid levels among thirty-four thousand people in Japan. Ann Rheum Dis. 1982;41(3):272–274. doi: https://doi.org/10.1136/ard.41.3.272
  12. Zitt E, Fischer A, Lhotta K, et al. Sex- and age-specific variations, temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort. Sci Rep. 2020;10(1):7578. doi: https://doi.org/10.1038/s41598-020-64587-z
  13. Mumford SL, Dasharathy SS, Pollack AZ, et al. Serum uric acid in relation to endogenous reproductive hormones during the menstrual cycle: Findings from the BioCycle study. Hum Reprod. 2013;28(7):1853–1862. doi: https://doi.org/10.1093/humrep/det085
  14. Hak AE, Curhan GC, Grodstein F, Choi HK. Menopause, postmenopausal hormone use and risk of incident gout. Ann. Rheum. Dis. 2010;69:1305–1309. doi: https://doi.org/10.1136/ard.2009.109884
  15. Ljubojevic M, Herak-Kramberger CM, Hagos Y, et al. Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition. Am. J. Physiol. Renal. Physiol. 2004;287:F124–F138. doi: https://doi.org/10.1152/ajprenal.00029.2004
  16. Cho SK, Winkler CA, Lee SJ, et al. The prevalence of hyperuricemia sharply increases from the late menopausal transition stage in middle-aged women. J Clin Med. 2019;8(3):E296. doi: https://doi.org/10.3390/jcm8030296
  17. Krishnan E, Bennett M, Chen L. Aging, not menopause, is associated with higher prevalence of hyperuricemia among older women. Menopause. 2014;21(11):1211–1216. doi: https://doi.org/10.1097/GME.0000000000000230
  18. Бойцов С.А., Чазов Е.И., Шляхто Е.В., и др. Эпидемиология сердечно-сосудистых заболеваний в различных регионах России (ЭССЕ-РФ). Обоснование и дизайн исследования // Профилактическая медицина. — 2013. — № 6. — С. 25–34. [Boitsov SA, Chazov EI, Shlyakhto EV, et al. Scientific Organizing Committee of the ESSE-RF. Epidemiology of cardiovascular diseases in different regions of Russia (ESSE-RF). The rationale for and design of the study. Profilakticheskaya meditsina [The Russian Journal of Preventive Medicine and Public Health]. 2013;(6):25–34. (In Russ.)]
  19. Maksimov S, Karamnova N, Shalnova S, Drapkina O. Sociodemographic and regional determinants of dietary patterns in Russia. Int J Environ Res Public Health. 2020;17(1):328. doi: https://doi.org/10.3390/ijerph17010328
  20. Максимов С.А., Карамнова Н.С., Шальнова С.А., и др. Эмпирические модели питания в российской популяции и факторы риска хронических неинфекционных заболеваний (исследование ЭССЕ-РФ) // Вопросы питания. — 2019. — Т. 88. — № 6. — С. 22–33. [Maksimov SA, Karamnova NS, Shalnova SA, et al. Empirical dietary patterns in the Russian population and the risk factors of chronic non-infectious diseases (Research ESSE-RF). Voprosy pitaniia [Problems of Nutrition]. 2019;88(6):22–33. (In Russ.)] doi: https://doi.org/10.24411/0042-8833-2019-10061
  21. Шальнова С.А., Максимов С.А., Баланова Ю.А., и др. Потребление алкоголя и зависимость от социально-демографических факторов у лиц трудоспособного возраста (по данным исследования ЭССЕ-РФ) // Профилактическая медицина. — 2019. — Т. 22. — № 5. — С. 45–53. [Shalnova SA, Maksimov SA, Balanova YA, et al. Alcohol consumption and dependence on sociodemographic factors in able-bodied people (according to the ESSE-RF study). Profilakticheskaya meditsina [The Russian Journal of Preventive Medicine and Public Health]. 2019;22(5):45–53. (In Russ.)]. doi: https://doi.org/10.17116/profmed20192205145
  22. Stöckl D, Döring A, Thorand B, et al. Reproductive factors and serum uric acid levels in females from the general population: The KORA F4 Study. PLoS One. 2012;7(3):e32668. doi: https://doi.org/10.1371/journal.pone.0032668
  23. Wan H, Zhang K, Wang Y, et al. The associations between gonadal hormones and serum uric acid levels in men and postmenopausal women with diabetes. Front Endocrinol (Lausanne). 2020;11:55. doi: https://doi.org/10.3389/fendo.2020.00055
  24. Hak AE, Curhan GC, Grodstein F, Choi HK. Menopause, postmenopausal hormone use and risk of incident gout. Ann Rheum Dis. 2010;69(7):1305–1309. doi: https://doi.org/10.1136/ard.2009.109884
  25. Simon JA, Lin F, Vittinghoff E, Bittner V. The relation of postmenopausal hormone therapy to serum uric acid and the risk of coronary heart disease events: The Heart and Estrogen-Progestin Replacement Study (HERS). Ann Epidemiol. 2006;16(2):138–1345. doi: https://doi.org/10.1016/j.annepidem.2005.04.003
  26. Pinkerton JAV, Aguirre FS, Blake J, et al. The 2017 hormone therapy position statement of the North American Menopause Society. Menopause. 2017;24(7):728–753. doi: https://doi.org/10.1097/GME.0000000000000921

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