Extracellular neutrophil traps (NETs) in the pathogenesis of thrombosis and thromboinflammation

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Abstract


This article summarizes numerous studies on the relationship of biological processes such as inflammation and thrombosis. The huge role of neutrophils and the extracellular neutrophil traps (NETs) secreted by them has been demonstrated. The discovery of NETs has opened new horizons in the understanding of neutrophil biology and the role of these cells in the body. The use of chromatin in combination with the intracellular proteins, as an effective antimicrobial agent has ancient roots and changes our understanding of chromatin only as a carrier of genetic information. Through NETs, neutrophils can contribute to the development of pathological venous and arterial thrombosis or “immunothrombosis”, as well as atherosclerosis. NETs release has been shown to be one of the causes of thrombosis in conditions such as sepsis and cancer. The presence of NETs in these diseases and conditions makes it possible to use them or individual components as potential biomarkers. NETs and their components may be attractive as therapeutic targets. Further studies of neutrophils and NETs are needed to develop new approaches to the diagnosis and treatment of inflammatory and thrombotic conditions. Perhaps long-forgotten drugs will find a new area for effective use.


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About the authors

Victoria O. Bitsadze

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: vikabits@mail.ru
ORCID iD: 0000-0001-8404-1042
SPIN-code: 5930-0859

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

MD, PhD, Professor

Ekaterina V. Slukhanchuk

Petrovsky National Research Center of Surgery

Email: beloborodova@rambler.ru
ORCID iD: 0000-0001-7441-2778
SPIN-code: 7423-8944

Russian Federation, 2, Abrikosovsky pereulok, Moscow, 119991

MD, PhD, Assistant Professor

Jamilya H. Khizroeva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: jamatotu@gmail.com
ORCID iD: 0000-0002-0725-9686
SPIN-code: 8225-4976
Scopus Author ID: 57194547147
ResearcherId: F-8384-2017

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

MD, PhD, Professor

Maria V. Tretyakova

The First I.M. Sechenov Moscow State Medical University (Sechenov University); Medical Center LLC

Email: tretyakova777@yandex.ru
ORCID iD: 0000-0002-3628-0804
SPIN-code: 1463-0065

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992; Timura Frunze str.15/1, 119021, Moscow

MD, PhD, Assistant Professor

Andrei S. Shkoda

L.A. Vorokhobov City Clinical Hospital Sixty-seven

Email: 67gkb@mail.ru
ORCID iD: 0000-0002-9783-1796

Russian Federation, 2/44, Salyama Adilya str., Moscow, 123423

MD, PhD, Professor

Liudmila S. Radetskaya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: udaeva@gmail.com
ORCID iD: 0000-0003-3410-6885
SPIN-code: 4554-7324

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

MD, Associated Professor

Alexander D. Makatsariya

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: gemostasis@mail.ru
ORCID iD: 0000-0001-7415-4633
SPIN-code: 7538-2966
https://internist.ru/lectors/detail/makatsariya-/

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

MD, PhD, Academician of the RAS

Ismail Elalamy

I.M. Sechenov Moscow State Medical University (Sechenov University); Medicine Sorbonne University, University Hospital Tenon

Email: ismail.elalamy@aphp.fr
ORCID iD: 0000-0002-9576-1368
Scopus Author ID: 7003652413

Russian Federation, Trubetskaya str. 8-2, 119991; rue de la Chine 75970 Paris Cédex 20, France

MD, PhD, Professor

Jean-Christophe Gris

I.M. Sechenov First Moscow State Medical University (Sechenov University); University Montpellier, France

Email: jean.christophe.gris@chu-nimes.fr
ORCID iD: 0000-0002-9899-9910
Scopus Author ID: 7005114260

Russian Federation, Trubetskaya str. 8-2, 119991, Moscow; Place du Pr. Robert Debré 30039 Nîmes cédex 09

MD, PhD, Professor

Elvira Grandone

The First I.M. Sechenov Moscow State Medical University, (Sechenov University);
Thrombosis and Haemostasis Research Unit, Fondazione I.R.C.C.S. "Casa Sollievo della Sofferenza"

Email: grandoneelvira@gmail.com
ORCID iD: 0000-0002-8980-9783
Scopus Author ID: 7006391091

Italy, Trubetskaya str. 8-2, 119991, Moscow; 71043, Viale Padre Pio, San Giovanni Rotondo, Foggia, Italy

MD, PhD, Professor, Department of thrombosis and hemostasis

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Supplementary files

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1.
Fig. 1. Suicidal netosis

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2.
Fig. 2. Vital netosis

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Fig. 3. Potential targets for therapy of thromboinflammatory diseases mediated by neutrophils and NETs

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