Ortopoxviruses: past, present and future

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  • Authors: Onishchenko G.G.1,2, Kirillov I.A.3, Makhlai A.4, Borisevich S.2,4
  • Affiliations:
    1. I.M. Sechenov First Moscow State Medical University (Sechenov University)
    2. Russian Academy of Sciences
    3. Management of the Сhief of the Nuclear, Biological and Chemical Protection Troops of the Armed Forces of the Russian Federation
    4. 48 Central Scientifi c Research Institute
  • Issue: Vol 75, No 4 (2020)
  • Pages: 300-305
  • Section: INFECTIOUS DISEASES: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/1363
  • DOI: https://doi.org/10.15690/vramn1363
  • Cite item
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Abstract


The analysis of scientific publication, dedicated to human pathogenic orthopoxviruses over the past 40 years is generalized. The essential activation of focies of monkeypox in Central Africa, cowpox in Europe, buffalopox in South-East Asia, camelpox in South-West and Central Asia and vaccinia-like viruses in Southern America is marked on the background of the apperance of three novel representatives of orthopoxviruses in North America (agents of volepox, raccoonpox and skunpox) and two representatives of African orthopoxviruses (agents of Uasingishu, named self-titled province of Kenya and taterpox).It is concluded, that this is facilitated by almost complete absence of anti-smallpox immunity after the elimination of smallpox and stopping immunization in the world on the background of active human intervention in the nature. Expert do not exclude, that as a result of a mutation of one of orthopoxviruses of animal, similar to smallpox virus agent will exist. Whereat the world will face a threat, much more serious that swine flu or avian flu. It is concluded that modern scientific and methodological approaches to study of orthopoxvirus infections evolution allow to predict threats, related on biological safety of Russian Federation.


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About the authors

Gennady G. Onishchenko

I.M. Sechenov First Moscow State Medical University (Sechenov University); Russian Academy of Sciences

Email: 48cnii@mil.ru

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992; 14, Leninskii boulevard, Moscow, 119991

MD, PhD, Professor, Academician of the RAS

Igor A. Kirillov

Management of the Сhief of the Nuclear, Biological and Chemical Protection Troops of the Armed Forces of the Russian Federation

Email: 48cnii@mil.ru

Russian Federation, Moscow

MD, PhD

Alexander Makhlai

48 Central Scientifi c Research Institute

Email: 48cnii@mil.ru

Russian Federation, Sergiev Posad, Moscow Region

MD, PhD, Professor

Sergei Borisevich

Russian Academy of Sciences; 48 Central Scientifi c Research Institute

Author for correspondence.
Email: sp_borisevich@mail.ru
ORCID iD: 0000-0002-6742-3919

Russian Federation, 14, Leninskii boulevard, Moscow, 119991; Sergiev Posad, Moscow Region

MD, PhD, Professor

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Supplementary files

Supplementary Files Action
1.
Figure: 1. Percentage of scientific publications presented in the American NSBI database for 1969–2017 devoted to smallpox, monkeypox, cowpox and camelpox (total)

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2.
Figure: 2. The number of scientific publications presented in the American NSBI database for 1969–2017 devoted to smallpox, monkeypox, cowpox, camelpox (by years)

View (155KB) Indexing metadata
3.
Figure: 3. Evolution of poxviruses

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