WHICH PATIENTS WITH OVARIAN CANCER SHOWS THE COMBINATION OF TRABECTEDIN WITH PEGYLATED LIPOSOMAL DOXORUBICIN

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Abstract

Given the high rate of recurrence of ovarian cancer, the search for new therapeutic strategies are topical issue. According to various studies the effectiveness of drug treatment relapse depends on the platinum-free interval, increasing in proportion to its duration. If therapy is platinum-resistant recurrent ovarian cancer is a standard approach, the treatment of platinum-sensitive recurrent algorithm is not fully defined. Comparison of platinum and non-platinum combinations revealed the advantage of combined platinum- treatment for patients with platinum-free interval of more than 6 months without an increase in life expectancy. Non-platinum combination of trabectedin with pegylated liposomal doxorubicin has shown comparable efficacy with an advantage in overall survival in patients with platinum-free interval of 6–12 months. A platinum-free interval prolongation by the use of non-platinum mode increases the efficiency of subsequent platinum-based therapy, increasing the life expectancy of patients . Currently under study molecular markers and prognostic factors allowing to define a group of patients who have the greatest benefit from the use trabectedin with pegylated liposomal doxorubicin as second-line chemotherapy.

 

About the authors

S. V. Khokhlova

N.N. Blokhin Russian Cancer Research Center of RAMS, Moscow, Russian Federation

Author for correspondence.
Email: svkhokhlova@mail.ru
MD, senior research scientist of Chemotherapy Department of FSBI “N.N. Blokhin Russian Cancer Research Center” of RAMS. Address: 24, Kashirskoe Highway, Moscow, RF, 115478; tel.: +7 (495) 324-19-19 Russian Federation

M. V. Cherkasova

Russian Medical Academy of Postgraduate Education, Moscow, Russian Federation

Email: m_cherkasova@mail.ru
postgraduate of the Department of Oncology of RMAPE. Address: 2/1, Barrikadnaya Street, Moscow, RF, 123995; tel.: (499) 252-21-04 Russian Federation

N. F. Orel

N.N. Blokhin Russian Cancer Research Center of RAMS, Moscow, Russian Federation
Russian Medical Academy of Postgraduate Education, Moscow, Russian Federation

Email: orel.nad@yandex.ru
PhD, leading research scientist of Chemotherapy Department of FSBI “N.N. Blokhin Russian Cancer Research Center” of RAMS, professor of the Department of Oncology of RMAPE. Address: 24, Kashirskoe Highway, Moscow, RF, 115478; tel.: +7 (495) 324-19-19 Russian Federation

S. V. Limareva

N.N. Blokhin Russian Cancer Research Center of RAMS, Moscow, Russian Federation

Email: limareva@yandex.ru
MD, research scientist of Chemotherapy Department of FSBI “N.N. Blokhin Russian Cancer Research Center” of RAMS. Address: 24, Kashirskoe Highway, Moscow, RF, 115478; tel.: +7 (495) 324-19-19 Russian Federation

I. Ya. Bazaeva

N.N. Blokhin Russian Cancer Research Center of RAMS, Moscow, Russian Federation

Email: irinabazaeva@rambler.ru
postgraduate of Chemotherapy Department of FSBI “N.N. Blokhin Russian Cancer Research Center” of RAMS. Address: 24, Kashirskoe Highway, Moscow, RF, 115478; tel.: +7 (495) 324-19-19 Russian Federation

V. A. Gorbunova

N.N. Blokhin Russian Cancer Research Center of RAMS, Moscow, Russian Federation

Email: veragorbounova@mail.ru
PhD, professor, Head of Chemotherapy Department of FSBI “N.N. Blokhin Russian Cancer Research Center” of RAMS. Address: 24, Kashirskoe Highway, Moscow, RF, 115478; tel.: +7 (495) 324-19-19 Russian Federation

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