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Folliculo-stellate cells are known as S-100 protein immunopositive cells of the anterior lobe of pituitary gland which are not secreting hormones and are presumed to be organ specific stem cells of the adenohypophys. Their role in adaptation of the body to stress remains unclear. Aim: to evaluate dynamics of folliculo-stellate and hormone-producing cells in rats of different age in chronic stress exposure. Materials and methods: Sprague-Dawley rats aged 1, 3, 6 and 12 months were exposed to chronic immersion immobilization stress. Histological section of the pituitary glands were stained immunohistochemically with subsequent image analysis. Results: in control rats S-100 protein-immunopositive cells increased in number with age and negatively correlated with the number of ACTH-positive cells. In experimental animals aged 1 and 3 months volume density of S-100 protein-immunoreactive cells significantly decreased and negatively correlated with ACTH-positive cells, while in 6 month old rats it was only slightly decreased and in 12 months old animals showed tendency to increase. Conclusions: results of the study demonstrating capacity of the folliculo-stellate cells to contribute to the plasticity of the hypothalamo-hypophyseo-adrenal axis in chronic stress exposure at different age.


About the authors

M. Yu. Kapitonova

UiTM, Selangor, Malaysia

Author for correspondence.
PhD, professor, Head of the Anatomy Department of General Medicine Faculty of University Technology MARA. Address: Shah Alam, Selangor, 40150 Malaysia; tel.: (6017) 624-36-99 Malaysia

M. Ullah

UiTM, Selangor, Malaysia

PhD, professor of the Anatomy Department of Dentistry Faculty of University Technology MARA. Address: Shah Alam, Selangor, 40150 Malaysia; tel.: (6012) 963-80-75 Malaysia

S. L. Kuznetsov

First Moscow State Medical University n.a. I.M. Sechenov, Russian Federation

PhD, professor, correspondent member of RAMS, Head of the Department of Histology and Fetology of I.M. Sechenov First MSMU. Address: build. 3, 11, Mokhovaya Street, Moscow, RF, 103009; tel.: +7 (495) 698-56-31 Russian Federation

V. V. Khlebnikov

Volgograd State Medical University, Russian Federation

assistant of the Neurologic Department of Volgograd State Medical University. Address: 1, Pavshikh bortsov Square, Volgograd, RF, 400066 Russian Federation

M.N.K. Nor-Ashikin

UiTM, Selangor, Malaysia

PhD, assistant professor, Director of the Institute of molecular health-related biotechnologies of University Technology MARA. Address: Sg Buloh, Selangor, 47000 Malaysia; tel.: (6012) 320-03-48 Malaysia

A. Ahmad

UiTM, Selangor, Malaysia

postgraduate of the Anatomy Department of General Medicine Faculty of University Technology MARA. Address: Shah Alam, Selangor, 40150 Malaysia; tel.: (6013) 246-11-06 Malaysia


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