Metabolic disorders in the pathogenesis of various causes of dizziness and instability

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Dizziness and instability are topical problem in the neurological practice. This health condition invades up to thirty percent of the whole population. However, pathogenic factors of development and tendency to chronic process of these nosological conditions are still poorly researched. The investigation of new pathogenic factors, including metabolic factors, is proceeding. The greatest amount of research was collected for benign paroxysmal positional vertigo (BPPV). The hypothesis of coincidence between BPPV, vitamin D deficiency and osteoporosis was created in 2003. However, the results are controversial. The complex of perfomed investigations let suspect vitamin D deficiency as biomarker of osteoporosis/osteopenia. But some other research works failed to support this conclusion. In some investigations the vitamin D deficiency as factor of recurrence of BPPV was discussed. The new hypothesis was correlation between otoneurological disorders and vitamin D deficiemcy due to it’s immunomodulation ability was proposed. Considerable part of the article deals with problem of endothelial dysfunction. The data about correlation between oxidative stress and BPPV was published, as far as the data about impact of hypehomocysteinemia to retardation of compensation for vestibular neuritis.

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About the authors

A. S. Bedenko

Sechenov First Moscow State Medical University

ORCID iD: 0000-0003-1570-6607
SPIN-code: 1533-6140

MD, PhD Student

Russian Federation, Moscow

L. М. Antonenko

Sechenov First Moscow State Medical University

Author for correspondence.
ORCID iD: 0000-0002-4400-8632
SPIN-code: 2700-0886
Scopus Author ID: 57193795209

MD, PhD, Professor 

Russian Federation, Moscow

A. N. Barinov

Sechenov First Moscow State Medical University

ORCID iD: 0000-0001-7146-2024
SPIN-code: 7128-2196


Russian Federation, Moscow


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