Modulation of instinal microbiom in the formation and progression of ulterative colitis.

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Abstract

In recent decades, an increase in the incidence of ulcerative colitis has been observed throughout the world. The purpose of this review is to generalize the available information on the influence of environmental factors and intestinal microbiome on the occurrence and development of ulcerative colitis, the role of bacteria metabolism products in the pathogenesis of the disease. Studied literature, we came to the conclusion that lifestyle in the era of post-industrial society has a significant impact on the microbial composition of the intestine and leads to changes in its diversity in patients suffering from ulcerative colitis. The changes include a decrease in the number of residential flora with anti-inflammatory activity, which synthesize short-chain fatty acids, and an increase in the number of potentially pathogenic and pathogenic microorganisms. Within the phylums Firmicutes and Proteobacteria, the proportional ratio changes. The combination of aggression factors (deterioration of the intestinal microbiome composition, the presence of aggressive intestinal metabolites) leads to intestinal mucosa permeability disfunction, impairing its barrier function. Food and bacterial agents can penetrate deeper layers of the intestinal wall through mucosal defects, which then stimulate the development of inflammatory and immune responses.

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About the authors

G. R. Bikbavova

Omsk State Medical University

Author for correspondence.
Email: galiya1976@mail.ru
ORCID iD: 0000-0001-9252-9152
SPIN-code: 6103-6690

MD, Associate Professor

Russian Federation, Omsk

M. A. Livzan

Omsk State Medical University

Email: mlivzan@yandex.ru
ORCID iD: 0000-0002-6581-7017
SPIN-code: 1961-4082

MD, Professor

Russian Federation, Omsk

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Supplementary files

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1. Рис. 1. Теория «истощения биома»

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2. Рис. 2. Упрощенная схема этапов повреждения слизистой оболочки толстой кишки при язвенном колите

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