The pathomorphosis of inflammatory bowel diseases

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Inflammatory bowel diseases (IBD) are immune-mediated diseases and usually manifest at a young age. They are requires in a long-term treatment or surgery with a high probability of surgical intervention. IBDs are accompanied by a decrease in working capacity, impaired quality of life and social disadaptation. However, timely diagnosis with using modern diagnostic methods, the use of evidence-based immunosuppressive and biological therapy significantly changed the pathomorphosis of this disease. But despite the achievements of the pharmacotherapy, the incidence and prevalence of IBD are still increasing, a demand for surgery remains both for Crohn`s disease and ulcerative colitis throughout all the period of illness. At the same time there is a trend towards the variability of symptoms, mismatch of the clinical symptoms with the real severity of inflammation, increase of a number of patients with extraintestinal manifestations and resistance to induction and maintenance therapies. In addition to this, the observation of this group of patients is complicated due to the difficulty of the early diagnosis and differential analysis of IBD, the need of early induction treatment according to the guidelines and the lack of adherence to the therapy.

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About the authors

Igor V. Maev

A.I. Yevdokimov Moscow State University of Medicine and Dentistry


Russian Federation, 20/1, Delegatskaya street, Moscow, 127473

MD, PhD, Professor

Yurii A. Shelygin

State research center of coloprotology named after A.N. Ryzhikh


Russian Federation, 2, Salyama Adilya street, Moscow, 123423

MD, PhD, Professor

Maria I. Skalinskaya

North-Western State Medical University n.a. I.I. Mechnikov

Author for correspondence.
ORCID iD: 0000-0003-0769-8176
SPIN-code: 2596-5555

Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015

Associate Professor

Alexey V. Veselov

State research center of coloprotology named after A.N. Ryzhikh

ORCID iD: 0000-0002-2533-8118
SPIN-code: 9333-8673

Russian Federation, 2, Salyama Adilya street, Moscow, 123423


Ekaterina V. Skazyvaeva

North-Western State Medical University n.a. I.I. Mechnikov

41, Kirochnaya street, Saint-Petersburg, 191015


Irina A. Rasmagina

North-Western State Medical University n.a. I.I. Mechnikov

ORCID iD: 0000-0003-3525-3289
SPIN-code: 6634-0342

Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015

resident in the specialty gastroenterology of the department of propaedeutics of internal diseases, gastroenterology and nutrition CM. Ryssa

Diana A. Komarova

North-Western State Medical University n.a. I.I. Mechnikov

ORCID iD: 0000-0001-8834-0912
SPIN-code: 3599-4519

Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015

medical student

Igor G. Bakulin

North-Western State Medical University n.a. I.I. Mechnikov

ORCID iD: 0000-0002-6151-2021
SPIN-code: 5283-2032

Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015

MD, PhD, Professor


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Supplementary files

Supplementary Files Action
Fig. 1. The distribution of the number of patients by year of primary diagnosis of ulcerative colitis or Crohn's disease

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Fig. 2. Dynamics of the frequency of primary diagnoses of inflammatory bowel diseases over 5-year periods with reflection of the shares of ulcerative colitis or Crohn's disease

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Fig. 3. The distribution of patients with ulcerative colitis according to the localization of the inflammatory process in the intestine

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Fig. 4. Distribution of patients with Crohn's disease by the frequency of detection of the localization of the lesion

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Fig. 5. The distribution of extraintestinal manifestations in patients with inflammatory bowel disease in groups

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Fig. 6. The nature of the performed surgical interventions to the patients of the Register during the medical history

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