Clinical and epidemiological features of papillomavirus infection manifestations on the example of cervical cancer and genital warts

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  • Authors: Briko N.I.1,2, Sekacheva M.I.1, Lopukhov P.D.1, Kobzev G.S.1, Kaprin A.D.3, Novikova E.G.3, Trushina O.I.3, Khaldin A.A.4, Maleev V.V.2
  • Affiliations:
    1. I.M. Sechenov First Moscow State Medical University (Sechenov University)
    2. Central Research Institute for Epidemiology
    3. P.A. Hertsen Moscow Oncology Research Center − branch of National Medical Research Center for Radiology
    4. Moscow Scientifi c and Practical Center of Dermato-Venereology and Cosmetology
  • Issue: Vol 75, No 1 (2020)
  • Pages: 77-82
  • Section: EPIDEMIOLOGY: CURRENT ISSUES
  • URL: https://vestnikramn.spr-journal.ru/jour/article/view/1212
  • DOI: https://doi.org/10.15690/vramn1212
  • Cite item
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Abstract


Background: Cervical cancer and genital warts (GWs) are some of the most common manifestations of human papillomavirus infection (HPV). These lesions cause significant damage to the reproductive health of the population, which leads to increased attention to the prevention of HPV infection among various population groups.

Aims: To determine the clinical and epidemiological features of the HPV manifestations by the example of cervical cancer and genital warts.

Methods: A retrospective analysis of anamnestic information of 115 women with an established diagnosis of cervical cancer and 177 patients with an established diagnosis of GWs was performed. The clinical and epidemiological characteristics of patients with diagnoses of GWs and cervical cancer were based on the development of outpatient admission cards and inpatient histories, as well as test data for HPV.

Results: HPV 16 was the most common HPV type among patients with GWs and cervical cancer ― it was detected in 37.6% of cases. Also the most frequently encountered: HPV 6/18/11/31/51/52. In 43.2% cases of HPV detection, two or more types were detected at once, the most common combinations: HPV16 and HPV18, HPV6 and HPV16, HPV6 and HPV11. Analysis of the frequency of screening for cervical cancer and visits to the gynecologist for 5 years before establishing the diagnosis showed that among those who did not screen for cervical cancer, the risk of diagnosing stage II–IV was 5.2 times higher than among individuals who underwent cervical screening 2 years ago, or once a year for the last five years. Among patients with GWs who had 2 or more sexual partners for 1 year, 13.5% of patients regularly used barrier contraception methods (condoms) during sexual contact, not regularly ― 61.5%, did not use them at all ― 25.0%.

Conclusions: Identifying the clinical and epidemiological features of HPV infection should contribute to the development of new and optimize existing prevention programs for a wide range of HPV-associated diseases.


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About the authors

Nikolay I. Briko

I.M. Sechenov First Moscow State Medical University (Sechenov University); Central Research Institute for Epidemiology

Email: nbrico@mail.ru
ORCID iD: 0000-0002-6446-2744
SPIN-code: 2992-6915
Scopus Author ID: 7004344976

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992; 3A, Novogireyevskaya street, Moscow, 111123

MD, PhD, Professor

Marina I. Sekacheva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: sekach_rab@mail.ru
ORCID iD: 0000-0003-0015-7094
SPIN-code: 4801-3742
Scopus Author ID: 24342526600

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

MD, PhD, Professor

Platon D. Lopukhov

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: PL2211@yandex.ru
ORCID iD: 0000-0002-0872-2214
SPIN-code: 1250-6839
Scopus Author ID: 57191340780
ResearcherId: S-8582-2017

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

MD, PhD

Gleb S. Kobzev

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: glebk09@mail.ru
ORCID iD: 0000-0002-1772-6401
SPIN-code: 9969-4457

Russian Federation, 8-2, Trubetskaya street, Moscow, 119992

resident of the department of epidemiology and evidence-based medicine

Andrey D. Kaprin

P.A. Hertsen Moscow Oncology Research Center − branch of National Medical Research Center for Radiology

Email: mnioi@mail.ru
ORCID iD: 0000-0001-8784-8415
SPIN-code: 1759-8101
Scopus Author ID: 6602709853

Russian Federation, 3, 2 Botkinskii ave., Moscow, 125284

MD, PhD, Professor

Elena G. Novikova

P.A. Hertsen Moscow Oncology Research Center − branch of National Medical Research Center for Radiology

Email: mnioi@mail.ru
ORCID iD: 0000-0003-2768-5698
SPIN-code: 2143-9975
Scopus Author ID: 7102446296

Russian Federation, 3, 2 Botkinskii ave., Moscow, 125284

MD, PhD, Professor

Olga I. Trushina

P.A. Hertsen Moscow Oncology Research Center − branch of National Medical Research Center for Radiology

Email: o.trushina@list.ru
ORCID iD: 0000-0003-3462-333X
SPIN-code: 9885-3814
Scopus Author ID: 6506506500

Russian Federation, 3, 2 Botkinskii ave., Moscow, 125284

MD, PhD

Aleksey A. Khaldin

Moscow Scientifi c and Practical Center of Dermato-Venereology and Cosmetology

Email: khaldinderma@yandex.ru
ORCID iD: 0000-0002-3855-1655
SPIN-code: 4640-1950
Scopus Author ID: 7801322925

Russian Federation, 20, Seleznevskaya str., Moscow, 127473

MD, PhD, Professor

Viktor V. Maleev

Central Research Institute for Epidemiology

Email: crie@pcr.ru
ORCID iD: 0000-0001-5748-178X
SPIN-code: 1712-9809
Scopus Author ID: 7006690997

Russian Federation, 3A, Novogireevskaya str., Moscow, 111123

MD, PhD, Professor

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