CLINICAL-ANAMNESTIC AND MOLECULAR-GENETIC FACTORS IN DIFFERENT FORMS OF HYPERTENSION AND ITS RELATIONSHIP TO COURSE AND PREGNANCY OUTCOMES

Cover Page

Abstract


Aim: to assess of the relationship of clinical and molecular genetic factors in the course and outcome of pregnancy in different forms of hypertension in pregnant women. Patients and methods: a total of 125 pregnant women who were divided into the following groups: with chronic hypertension (n =45), with gestational hypertension (n =20), with pre-eclampsia (n =10), superimposed preeclampsia upon chronic hypertension (n =15) and 35 women without hypertension in control group. Results: in pregnant women with chronic hypertension and superimposed preeclampsia upon chronic hypertension were observed higher incidence of overweight and obesity, smoking before pregnancy and family history of hypertension and thrombosis, the course and outcomes of pregnancy characterized by higher frequency of obstetric complications, higher frequency of polymorphisms of genes identified the renin-angiotensin system, folate cycle and endothelial function. Conclusions: Molecular-genetic factors, combined with the factors of cardiovascular risk may make some contribution to the phenotypic realization of pregnancy complications and adverse pregnancy outcomes in pregnant women with different forms of hypertension.

 


V. S. Chulkov

South Ural State Medical University, Chelyabinsk, Russian Federation

Author for correspondence.
Email: vschulkov@rambler.ru

Russian Federation MD, assistant professor of the Department of Intermediate Level Therapy of Yuzhno-Ural’skii State Medical University. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092, tel.: (351) 253-65-71, e-mail: vschulkov@rambler.ru

N. K. Vereina

South Ural State Medical University, Chelyabinsk, Russian Federation

Email: vereinank@is74.ru

Russian Federation PhD, professor of the Department of Intermediate Level Therapy of Yuzhno-Ural’skii State Medical University. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092, tel.: (351) 253-65-71

S. P. Sinitsyn

South Ural State Medical University, Chelyabinsk, Russian Federation

Email: sinitsinsp@is74.ru

Russian Federation PhD, professor, Head of the Department of Intermediate Level Therapy of Yuzhno-Ural’skii State Medical University. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092, tel.: (351) 253-69-29

V. F. Dolgushina

South Ural State Medical University, Chelyabinsk, Russian Federation

Email: kanc@chelsma.ru

Russian Federation PhD, PhD, professor, Head of the Department of Obsterics and Gynecology of YuzhnoUral’skii State Medical University. Address: 64, Vorovskogo Street, Chelyabinsk, RF, 454092, tel.: (351) 232-73-71

  1. Gipertenziya vo vremya beremennosti. Preeklampsiya. Eklampsiya. Klinicheskii protokol. FGBU «NTs AGiP im. akad. Kulakova». Minzdravsotsrazvitiya Rossii. Institut Zdorov'ya sem'i. Proekt «Mat' i ditya» [Hypertension across Pregnancy. Preeclampsia. Eclampsia. Clinical Report. FSBI “V.I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology" Ministry of Healthcare and Social Development of the Russian Federation. Institute of Family Health. Project “Mother and Child”]. Moscow, 2012. 44 p.
  2. Diagnostika i lechenie serdechno-sosudistykh zabolevanii pri beremennosti. Natsional'nye rekomendatsii [Diagnosis and Treatment of Cardiovascular Diseases across Pregnancy. National Guideline]. Moscow, 2010. 40 p.
  3. Ailamazyan E.K., Mozgovaya E.V. Gestoz: teoriya i praktika [Gestational Toxicosis: Theory and Practice]. Moscow, MEDpress-inform, 2008. 272 p.
  4. Glotov A.S., Vashukova E.S., Kanaeva M.D., Kurilov R.V., Bikmullina D.R., Zainulina M.S., Ivashchenko T.E., Baranov V.S. Zhurn. akush. i zhen. boleznei = Journal of obsterics and women diseases. 2012; 3: 61–68.
  5. Volkova E.G., Bogdanov S.V., Zhavoronkova E.Yu., Kovalenko D.B. Arterial'naya gipertenziya = Arterial hypertension. 2008; 4(4): 10–15.
  6. Sinitsyn S.P., Chulkov V.S., Vereina N.K. Arterial'naya gipertenziya = Arterial hypertension. 2009; 15(5): 580–584.
  7. Tkacheva O.N., Bevz A.Yu., Chukhareva N.A., Novikova I.M., Sharashkina N.V. Farmateka = Pharmateca. 2010; 9: 44–51.
  8. Savel'eva I.V. Ross. vestn. akushera-ginekologa = Russian bulletin of obstetrician-gynecologist. 2010; 2: 28–31.
  9. Makarov O.V., Volkova E.V., Ponimanskaya M.A. Lechebnoe delo = Medical care. 2011; 1: 49–55.
  10. Sidorova I.S., Nikitina N.A., Unanyan A.L., Rzaeva A.A., Kinyakin V.V. Akusherstvo i ginekologiya - Obstetrics and Gynecology. 2013; 2: 35–40.
  11. Sukhikh G.T., Vikhlyaeva E.M., Kholin A.M. Terapevticheskii Arkhiv = Therapeutic Archive. 2009; 10: 5–9.
  12. Nakayama T., Yamamoto T. Comparison between essential hypertension and pregnancy-induced hypertension: a genetic perspective. Endocr. J. 2009; 56 (8): 921–934.
  13. Valenzuela F.J., Pérez-Sepúlveda A., Torres M.J., Correa P., Repetto G.M., Illanes S.E. Pathogenesis of preeclampsia: the genetic component. J. Pregnancy. 2012; 632732: Epub 2011 Dec 1.

Views

Abstract - 15

PDF (Russian) - 3

Cited-By


PlumX



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.