Principles of Diagnosis and Personalized Treatment of Hereditary Colorectal Cancer

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Abstract

The most frequent forms of hereditary colorectal cancer syndromes are Lynch syndrome and familial adenomatous polyposis (FAP). All the patients with suspicion to these syndromes need precise clinical and genetic diagnostics. Affected patients need personalized program of treatment because standard algorithm cannot be considered sufficiently effective. Identification of a pathogenic mutation in a patient indicates the need for DNA diagnostics in his close relatives and only in this case all the carriers of pathogenic germline mutations can be included in the high-risk group. Algorithms of clinical monitoring and operative treatment for mutation carriers were developed in different countries. However, different populations have their own genetic and clinical features. The aim of this work was to highlight the principles of diagnosis and personalized treatment of patients with hereditary colorectal cancer, taking into account international and Russian recommendations.

About the authors

Alexey S. Tsukanov

State Scientific Centre of Coloproctology

Author for correspondence.
Email: tsukanov81@rambler.ru
ORCID iD: 0000-0001-8571-7462

MD, PhD.

123423, Salyam Adil str. 2, Moscow.

SPIN-код: 4005-0998

Россия

Yury A. Shelygin

State Scientific Centre of Coloproctology

Email: info@gnck.ru
ORCID iD: 0000-0002-8480-9362

Director, MD, PhD, professor.

123423, Salyam Adil str. 2, Moscow.

SPIN-код: 7989-8228

Россия

Sergey I. Achkasov

State Scientific Centre of Coloproctology

Email: ackasovy@mail.ru
ORCID iD: 0000-0001-9294-5447

MD, PhD, professor.

123423, Salyam Adil str. 2, Moscow.

SPIN-код: 4005-0998

Россия

Sergey A. Frolov

State Scientific Centre of Coloproctology

Email: safrolov@mail.ru

MD, PhD.

123423, Salyam Adil str. 2, Moscow.

SPIN-код: 9645-4800

Россия

Vladimir N. Kashnikov

State Scientific Centre of Coloproctology

Email: kashnikov-v@yandex.ru
ORCID iD: 0000-0002-5385-7898

MD, PhD.

123423, Salyam Adil str. 2, Moscow.

SPIN-код: 5797-4230

Россия

Alexander M. Kuzminov

State Scientific Centre of Coloproctology

Email: 9249591@mail.ru
ORCID iD: 0000-0002-7544-4752

MD, PhD, professor.

123423, Salyam Adil str. 2, Moscow.

SPIN-код: 4255-0201

Россия

Dmitry Yu. Pikunov

State Scientific Centre of Coloproctology

Email: pikunov.gnck@mail.ru
ORCID iD: 0000-0001-7040-6979

MD, PhD.

123423, Salyam Adil str. 2, Moscow.

SPIN-код: 6995-3055

Россия

Vitaly P. Shubin

State Scientific Centre of Coloproctology

Email: shwit@mail.ru
ORCID iD: 0000-0002-3820-7651

PhD.

123423, Salyam Adil str. 2, Moscow.

SPIN-код: 6308-6586

Россия

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