CURRENT CONCEPTS OF PERINATAL ISCHEMIC INJURY IN THE BRAIN NEUROVASCULAR UNIT: MOLECULAR TARGETS FOR NEUROPROTECTION

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Abstract


Perinatal hypoxic-ischemic brain injury is a relevant medical and social problem. Among many pathological processes in the neonatal period perinatal hypoxic-ischemic injury is a major cause of further hemorrhage, necrotic and atrophic changes in the brain.  This review presents recent data on the basic mechanisms of the hypoxic-ischemic brain injury along the concept of neurovascular unit (neurons, astrocytes, endothelial cells, pericytes) with the focus on alterations in cell-to-cell communication. Pathological changes caused by ischemia-hypoxia are considered within two phases of injury (ischemic phase and reperfusion phase). The review highlights changes in each individual component of the neurovascular unit and their interactions. Molecular targets for pharmacological improvement of intercellular communication within neurovascular unit as a therapeutic strategy in perinatal brain injury are discussed.

 


About the authors

A. V. Morgun

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Russian Federation

Author for correspondence.
Email: 441682@mail.ru

Russian Federation MD, assistant of Pediatric Department of Krasnoyarsk State Medical University. Address: 1, P. Zheleznyak Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 243-39-52

N. V. Kuvacheva

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Russian Federation

Email: natalya.kuvacheva@gmail.com

Russian Federation MD, associate professor of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry of Krasnoyarsk State Medical University. Address: 1, P. Zheleznyak Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 228-07-69

T. E. Taranushenko

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Russian Federation

Email: tetar@mail.ru

Russian Federation PhD, professor, Head of Pediatric Department of Krasnoyarsk State Medical University. Address: 1, P. Zheleznyak Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 243-39-52

E. D. Khilazhieva

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Russian Federation

Email: elena.hilazheva@mail.ru

Russian Federation assistant of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry of Krasnoyarsk State Medical University Address: 1, P. Zheleznyak Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 228-07-69

N. A. Malinovskaya

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Russian Federation

Email: konsuelo81@mail.ru

Russian Federation MD, research scientist of Research Institute of Molecular Medicine and Pathobiochemistry of Krasnoyarsk State Medical University. Address: 1, P. Zheleznyak Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 228-07-69

Ya. V. Gorina

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Russian Federation

Email: yana_20@bk.ru

Russian Federation MD, senior lecturer of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry of Krasnoyarsk State Medical University. Address: 1, P. Zheleznyak Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 228-07-69

E. A. Pozhilenkova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Russian Federation

Email: pozhilenkova@yandex.ru

Russian Federation MD, associate professor of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry of Krasnoyarsk State Medical University. Address: 1, P. Zheleznyak Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 228-07-69

O. V. Frolova

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Russian Federation

Email: frolova_olga86@mail.ru

Russian Federation research scientist of Research Institute of Molecular Medicine and Pathobiochemistry of Krasnoyarsk State Medical University. Address: 1, P. Zheleznyak Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 228-07-69

A. B. Salmina

Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky, Russian Federation

Email: allasalmina@mail.ru

Russian Federation PhD, professor, Head of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry of Krasnoyarsk State Medical University. Address: 1, P. Zheleznyak Street, Krasnoyarsk, RF, 660022; tel.: +7 (391) 228-07-69

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