MOLECULAR REGULATION OF PSEUDOMONAS AERUGINOSA BIOFILMS

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Abstract

Nowadays healthcare-associated infections caused Pseudomonas aeruginosa remain actual problem due to P. aeruginosa resistance to a wide range of antimicrobials and its ability to form biofilms that are 1000 times more resistant to antibiotics than free-living (plankton) cultures. P. aeruginosa biofilms forming is regulated by Quorum Sensing (QS) communication system which is controlled by inhibitors (Quorum sensing inhibitors, QSIs). An essential role in stabilization of biofilms belongs to extracellular DNA (eDNA) as a structural polyanionic polymer whereas its genetic function is not applicable. In addition, internal signal molecules c-di-GMP, cascade Gac/Rsm also participate in formation of P. aeruginosa biofilms. A review provides a detailed description of the biofilm molecular regulation by means of QS inhibitors and QS modulators of signaling molecules QS.

About the authors

Oksana Y. Manzenyuk

FBIS State Research Center for Applied Microbiology and Biotechnology

Author for correspondence.
Email: macebarron2013@gmail.com
ORCID iD: 0000-0002-8641-8517

MD, PhD.

Obolensk, Serpukhov district, Moscow region.

SPIN-код: 6871-5381

Russian Federation

Victoria V. Firstova

FBIS State Research Center for Applied Microbiology and Biotechnology

Email: victoria1@mai.ru
ORCID iD: 0000-0002-9898-9894

PhD.

Obolensk, Serpukhov district, Moscow region.

SPIN-код: 9166-9151

Russian Federation

Tatiana N. Mukhina

FBIS State Research Center for Applied Microbiology and Biotechnology

Email: cecile98@rambler.ru
ORCID iD: 0000-0001-5829-0512

PhD.

Obolensk, Serpukhov district, Moscow region.

SPIN-код: 6858-5052

Russian Federation

Igor G. Shemyakin

FBIS State Research Center for Applied Microbiology and Biotechnology

Email: shemyakin@obolensk.org
ORCID iD: 0000-0001-9667-1674

PhD, Professor.

Obolensk, Serpukhov district, Moscow region.

SPIN-код: 3180-1459

Russian Federation

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