MOLECULAR REGULATION OF PSEUDOMONAS AERUGINOSA BIOFILMS

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Abstract


Nowadays healthcare-associated infections caused Pseudomonas aeruginosa remain actual problem due to P. aeruginosa resistance to a wide range of antimicrobials and its ability to form biofilms that are 1000 times more resistant to antibiotics than free-living (plankton) cultures. P. aeruginosa biofilms forming is regulated by Quorum Sensing (QS) communication system which is controlled by inhibitors (Quorum sensing inhibitors, QSIs). An essential role in stabilization of biofilms belongs to extracellular DNA (eDNA) as a structural polyanionic polymer whereas its genetic function is not applicable. In addition, internal signal molecules c-di-GMP, cascade Gac/Rsm also participate in formation of P. aeruginosa biofilms. A review provides a detailed description of the biofilm molecular regulation by means of QS inhibitors and QS modulators of signaling molecules QS.


Oksana Y. Manzenyuk

FBIS State Research Center for Applied Microbiology and Biotechnology

Author for correspondence.
Email: macebarron2013@gmail.com
ORCID iD: 0000-0002-8641-8517

Russian Federation

MD, PhD.

Obolensk, Serpukhov district, Moscow region.

SPIN-код: 6871-5381

Victoria V. Firstova

FBIS State Research Center for Applied Microbiology and Biotechnology

Email: victoria1@mai.ru
ORCID iD: 0000-0002-9898-9894

Russian Federation

PhD.

Obolensk, Serpukhov district, Moscow region.

SPIN-код: 9166-9151

Tatiana N. Mukhina

FBIS State Research Center for Applied Microbiology and Biotechnology

Email: cecile98@rambler.ru
ORCID iD: 0000-0001-5829-0512

Russian Federation

PhD.

Obolensk, Serpukhov district, Moscow region.

SPIN-код: 6858-5052

Igor G. Shemyakin

FBIS State Research Center for Applied Microbiology and Biotechnology

Email: shemyakin@obolensk.org
ORCID iD: 0000-0001-9667-1674

Russian Federation

PhD, Professor.

Obolensk, Serpukhov district, Moscow region.

SPIN-код: 3180-1459

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